Abstract: A ventilation device may include first and second supply ducts, a mixing section having a mixing duct into which the first and second supply ducts may lead, the first and second supply ducts arranged in the mixing section adjacent one another in a transverse direction, and first and second guides in the mixing section each running in the transverse direction and being located opposite one another in a longitudinal direction running transversely to the transverse direction, each guide having two guide walls running in the transverse direction and located opposite one another in a height direction running transversely to the transverse direction and longitudinal direction, at least one of the guide walls sloping away from the other guide wall at a slope angle with respect to the longitudinal direction.

Abstract: A housing may include a first housing part and a second housing part. The first housing part may include a first latching contour having at least one first latching lug. The first housing part may include at least one further latching contour having at least one further latching lug. The second housing part may be connected to the first housing part via a latching connection. The second housing part may include at least one counter-latching contour.

Abstract: The present application pertains inter alia to an isolated vertebrate cell suitable for recombinant expression of a polypeptide of interest, wherein the vertebrate cell is altered to impair the function of the endogenous protease matriptase and wherein said cell comprises at least one heterologous polynucleotide encoding a polypeptide of interest and wherein the polypeptide of interest is secreted by the cell. It was found that using respective vertebrate cells for producing a recombinant polypeptide of interest significantly reduces clipping of the polypeptide of interest that is secreted into the cell culture medium. Also provided are improved production and screening methods.

Abstract: An air-conditioning system for air-conditioning a vehicle interior is disclosed. The air-conditioning system includes a blower for generating an air flow, a heating device for heating the air flow, and a ducting system that divides the air flow downstream of the heating device over at least two part air flows and supplies the at least two part air flows via associated ducts to associated air outlets, through which the part air flows exit into the vehicle interior. The heating device includes at least two separate regions each with at least one electric heating element that is separately controllable via a control device. The at least two separate regions are each permanently assigned one of the associated ducts of the ducting system.

Abstract: A combined bypass filter element module is disclosed. The combined bypass filter element module includes at least one filter slot for receiving at least one filter element that can be arranged in the at least one filter slot. A bypass flap device is arranged in a flow direction in parallel with the at least one filter slot.

Abstract: A filter device of a motor vehicle may include a step filter, two flow paths, and a plurality of adjustable air flaps. The step filter may include a plurality of individual filter elements arranged fluidically in series. A first flow path may extend through at least two individual filter elements. A second flow path may extend through a number of the plurality of individual filter elements which, compared to a number of the plurality of individual filter elements through which the first flow path extends, may be reduced by at least one single individual filter element. The plurality of adjustable air flaps may be arranged at least one of upstream and downstream of the step filter. At least one air stream may be guidable through the step filter along at least one of the first flow path and the second flow path via the plurality of adjustable air flaps.

Abstract: A flap stopper for a rotatable flap for controlling an air flow may include a round bearing support disc, a round stopper support disc, stop elements, and connecting ribs. The stopper support disc may be spaced apart from the bearing support disc in an axial direction. The stop elements may be arranged on the stopper support disc. The connecting ribs may be arranged between the bearing support disc and the stopper support disc. The bearing support disc, the stopper support disc, the stop elements, and the connecting ribs may be formed as an integral plastic injection-molded part.

Abstract: An air conditioning system of a motor vehicle, having a housing with at least two independent air ducts formed therein, which are arranged separately from each other by at least one partition wall in the housing. A cooling heat exchanger is arranged in the housing such that it is flowed through by air, which can flow into the at least two independent air ducts. A heating heat exchanger is arranged in the housing such that it protrudes into the at least two independent air ducts and is flowed through by air of the at least two independent air ducts. The heating heat exchanger being an electrically operable heat exchanger, which is formed with several independently heated heat exchanger areas, so that the air flowing through an heat exchanger area is independently heatable and each independent air duct is provided at least one heat exchanger area.

Abstract: A shaft-bearing bush assembly for a valve arrangement for an air-conditioning system is disclosed. The shaft-bearing bush assembly includes a shaft drive-connectable to a valve of the valve arrangement and a bearing bush, in which the shaft is rotatably received relative to the bearing bush between a first rotary position and a second rotary position about an axis of rotation extending along the axial direction. A bush projection is non-rotatably arranged on the bearing bush relative to the bearing bush and a shaft projection is non-rotatably arranged on the shaft relative to the shaft. The bush projection and the shaft projection are matched to one another such that the bush projection provides a rotary stop for the shaft projection for limiting the rotary movement of the shaft between the first rotary position and the second rotary position.

Abstract: A HVAC system for a motor vehicle having a housing, wherein the housing has an air inlet for admitting air and a cold air path in which cold air flows is provided in the housing and a warm air path in which warm air flows is provided in the housing, wherein the warm air path and the cold air path open into a mixing chamber, wherein a mixing flap is provided for controlling the proportion of cold air flowing into the mixing chamber and the proportion of warm air flowing into the mixing chamber, wherein the mixing flap is arranged rotatable about an axis and is driven by a flap actuator which has a drive shaft, wherein a gear with a nonlinear translation characteristic is provided between the mixing flap and the drive shaft.

Abstract: The present application pertains inter alia to an isolated vertebrate cell suitable for recombinant expression of a polypeptide of interest, wherein the vertebrate cell is altered to impair the function of the endogenous protease matriptase and wherein the cell comprises at least one heterologous polynucleotide encoding a polypeptide of interest and wherein the polypeptide of interest is secreted by the cell. It was found that using respective vertebrate cells for producing a recombinant polypeptide of interest significantly reduces clipping of the polypeptide of interest that is secreted into the cell culture medium. Also provided are improved production and screening methods.

Abstract: An air-conditioning system for a motor vehicle may include at least two indirect heat exchangers through each of which both water and air is flowable. The water and the air may be fluidically separated from one another such that heat is transferable therebetween. The system may also include a warm water supply, a cold water supply, and at least two temperature-control devices each including a respective indirect heat exchanger of the at least two indirect heat exchangers. The warm and/or cold water supply may be in fluid communication with the at least two indirect heat exchangers. At least one indirect heat exchanger of the at least two indirect heat exchangers may communicate with the warm water supply and the cold water supply via an adjustable and controllable valve device such that a mixing ratio of a mixture of the warm water and the cold water introduced therein is adjustable.

Abstract: The disclosure pertains to novel eukaryotic cell suitable for recombinant production of a product of interest, wherein the genome of the host cell is altered so that the effect of protein FAM60A is impaired in said cell, e.g. by reducing or eliminating functional expression of gene FAM60A thereby improving the stability characteristics. Furthermore, the present disclosure provides associated technologies wherein such host cells are used in recombinant production technologies.

Abstract: The disclosure pertains to novel eukaryotic cell suitable for recombinant production of a product of interest, wherein the effect of the expression product of an endogenous gene C12orf35 is impaired in said cell, thereby increasing their productivity when recombinantly expressing a polypeptide of interest. Furthermore, the present disclosure provides associated technologies wherein such host cells are used in recombinant production technologies.

Abstract: A method for operating an air conditioning system, which may include a heating device, to condition air in a vehicle interior of a motor vehicle. At least one first air path and at least one second air path may each fluidically communicate with the air conditioning system and each open out into the vehicle interior. The method may include guiding the air from the vehicle interior via one of (i) the at least one first air path and (ii) the at least one second air path to the air conditioning system as a function of an operating state set in the air conditioning system. The method may also include guiding the air from the air conditioning system via the other of the one of (i) the at least one first air path and (ii) the at least one second air path into the vehicle interior.

Abstract: A motor vehicle air conditioning unit, having a housing with at least one air channel arranged therein and with at least one heat exchanger for conditioning the air in the at least one air channel, the housing having at least one first air outlet and one second air outlet, a first air outlet channel being assigned to the first air outlet and conducting air to the first air outlet, and a second air outlet channel being assigned to the second air outlet and conducting air to the second air outlet, a first vane valve and a second vane valve being provided. The first vane valve assigned to the first air outlet channel, and the second vane valve assigned to the second air outlet channel, the first vane valve and the second vane valve being rotatably fixedly connected to a shaft and being rotatable by an actuator driving the shaft.

Abstract: A housing may include a first housing part and a second housing part. The first housing part may include a first latching contour having at least one first latching lug. The first housing part may include at least one further latching contour having at least one further latching lug. The second housing part may be connected to the first housing part via a latching connection. The second housing part may include at least one counter-latching contour.

Abstract: The disclosure pertains to novel eukaryotic cell suitable for recombinant production of a product of interest, wherein the genome of the host cell is altered so that the effect of protein FAM60A is impaired in said cell, e.g. by reducing or eliminating functional expression of gene FAM60A thereby improving the stability characteristics. Furthermore, the present disclosure provides associated technologies wherein such host cells are used in recombinant production technologies.

Abstract: A flap stopper for a rotatable flap for controlling an air flow may include a round bearing support disc, a round stopper support disc, stop elements, and connecting ribs. The stopper support disc may be spaced apart from the bearing support disc in an axial direction. The stop elements may be arranged on the stopper support disc. The connecting ribs may be arranged between the bearing support disc and the stopper support disc. The bearing support disc, the stopper support disc, the stop elements, and the connecting ribs may be formed as an integral plastic injection-molded part.

Abstract: The disclosure pertains to novel eukaryotic cell suitable for recombinant production of a product of interest, wherein the effect of the expression product of an endogenous gene C12orf35 is impaired in said cell, thereby increasing their productivity when recombinantly expressing a polypeptide of interest. Furthermore, the present disclosure provides associated technologies wherein such host cells are used in recombinant production technologies.