Patents by Inventor Holger Paulsen

Holger Paulsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibacterial macrocycles
    Publication number: 20050107288
    Abstract: The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions comprising them, and their use in the treatment of diseases in humans or animals.
    Type: Application
    Filed: September 6, 2002
    Publication date: May 19, 2005
    Inventors: Berthold Hinzen, Heike Brotz-Oesterhelt, Rainer Endermann, Kerstin Henninger, Holger Paulsen, Siegfried Raddatz, Thomas Lampe, Veronika Hellwig, Andreas Schumacher
  • Substituted piperazine cyclohexane carboxilic acid amides and the use thereof
    Publication number: 20050054637
    Abstract: The present invention relates to substituted piperazinecyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in pharmaceuticals, in particular for the prophylaxis and/or treatment of cardiovascular disorders.
    Type: Application
    Filed: October 1, 2002
    Publication date: March 10, 2005
    Inventors: Erwin Bischoff, Thomas Krahn, Holger Paulsen, Joachim Schuhmacher, Henning Steinhagen, Wolfgang Thielemann
  • 3-'Hydroxy-(-4-trifluoromethylphenyl)-methyl-7-spirocyclobutyl-5,6,7 8-tetrahydroquinolin-5-ol derivatives and the use of the same as cholesterol ester transfer protein (cetp) inhibitors
    Publication number: 20050043341
    Abstract: The application relates to substituted tetrahydroquinoline derivatives, processes for their preparation and their use in medicaments.
    Type: Application
    Filed: September 18, 2002
    Publication date: February 24, 2005
    Inventors: Heike Gielen, Siegfried Goldmann, Jorg Keldenich, Holger Paulsen, Carsten Schmeck, Stephan Siegel, Hilmar Bischoff, Martin Raabe, Delf Schmidt, Christiane Faeste
  • Substituted cyclohexane derivatives and the use thereof in medicaments for treating cardiovascular diseases
    Publication number: 20040235830
    Abstract: The invention relates to substituted cyclohexane derivates of formula (I), a method for the production thereof and the use thereof in medicaments, particularly for preventing and/or treating cardiovascular diseases, diseases of the urogenital tract and cerebrovascular diseases.
    Type: Application
    Filed: April 22, 2004
    Publication date: November 25, 2004
    Inventors: Susanne Rohrig, Andreas Stolle, Julio C. Castro-Palomino, Helmut Haning, Gabriele Handke-Erguden, Noemi Daviu-Folguera, Holger Paulsen, Josef Pernerstorfer, Stephan-Nicholas Wirtz, Henning Steinhagen, Wolfgang Thielemann, Erwin Bischoff, Ulrich Ebbinghaus-Kintscher, Peter Ellinghaus, Joachim Hutter, Thomas Krahn, Frank Wunder, Klemens Lustig, Joachim Schuhmacher, Frank Sussmeier
  • Substituted phenylcyclohexane carboxylic acid amides that have an adenosine uptake inhibiting effect
    Publication number: 20040186106
    Abstract: The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) having adenosine-uptake-inhibiting action, to a process for their preparation and to their use in medicaments, in particular for treating ischaemic brain disorders.
    Type: Application
    Filed: March 18, 2004
    Publication date: September 23, 2004
    Applicant: Bayer Healthcare AG
    Inventors: Wolf-Dietrich Freund, Stephan Lensky, Stephan-Nicholas Muller, Holger Paulsen, Jorg Keldenich, Ervin Horvath, Joachim Schuhmacher
  • Substituted phenylcyclohexanecarboxamides and their use
    Publication number: 20040122004
    Abstract: The present invention relates to substituted phenylcyclohexanecarboxamides of the Formula (I) 1
    Type: Application
    Filed: November 17, 2003
    Publication date: June 24, 2004
    Applicant: Bayer Aktiengesellschaft
    Inventors: Erwin Bischoff, Thomas Krahn, Stephan-Nicholas Muller, Holger Paulsen, Joachim Schuhmacher, Henning Steinhagen, Wolfgang Thielemann
  • Substituted phenylcyclohexane carboxylic acid amides that have an adenosine uptake inhibiting effect
    Patent number: 6716849
    Abstract: The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) having adenosine-uptake-inhibiting action, to a process for their preparation and to their use in medicaments, in particular for treating ischaemic brain disorders.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: April 6, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolf-Dietrich Freund, Stephan Lensky, Stephan Nicholas Müller, Holger Paulsen, Jörg Keldenich, Ervin Horváth, Joachim Schuhmacher
  • Substituted phenylcyclohexanecarboxamides and their use
    Patent number: 6649616
    Abstract: The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of cardiovascular disorders.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: November 18, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erwin Bischoff, Thomas Krahn, Stephan-Nicholas Müller, Holger Paulsen, Joachim Schuhmacher, Henning Steinhagen, Wolfgang Thielemann
  • Substituted tetrahydronaphthaline and analogous compounds
    Patent number: 6586613
    Abstract: Substituted tetrahydro-naphthalenes and analogous compounds are prepared by reducing or condensing appropriate functional substituents in substituted tetrahydro-naphthalenes and analogous compounds by customary methods and converting functional groups in this manner into the desired groups. The compounds according to the invention are suitable for use as active compounds in pharmaceuticals, in particular in pharmaceuticals for treating arteriosclerosis and also dyslipidaemias.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: July 1, 2003
    Assignee: Bayer Aktiengellschaft
    Inventors: Arndt Brandes, Michael Lögers, Jürgen Stoltefuss, Gunter Schmidt, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Stefan Antons, Holger Paulsen, Stephan Nicholas Müller, Paul Naab, Carsten Schmeck
  • Substituted phenylcyclohexanecarboxamides and their use
    Publication number: 20030008881
    Abstract: The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) 1
    Type: Application
    Filed: August 30, 2001
    Publication date: January 9, 2003
    Inventors: Erwin Bischoff, Thomas Krahn, Stephan-Nicholas Muller, Holger Paulsen, Joachim Schuhmacher, Henning Steinhagen, Wolfgang Thielemann
  • Inhibition of p38 kinase activity by aryl ureas
    Publication number: 20020103253
    Abstract: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.
    Type: Application
    Filed: September 7, 2001
    Publication date: August 1, 2002
    Applicant: BAYER CORPORATION
    Inventors: Gerald Ranges, William Scott, Michael Bombara, Deborah Rauner, Aniko Redman, Roger Smith, Holger Paulsen, David Gunn, Jinshan Chen, Joel Renick
  • Inhibition of p38 kinase activity by aryl ureas
    Patent number: 6344476
    Abstract: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: February 5, 2002
    Assignee: Bayer Corporation
    Inventors: Gerald Ranges, William Scott, Michael Bombara, Deborah Rauner, Aniko Redman, Roger Smith, Holger Paulsen, David Gunn, Jinshan Chen, Joel Renick
  • Cycloalkano-pyridines
    Patent number: 6207671
    Abstract: The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hypertipoproteinaemia and arteriosclerosis.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: March 27, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Arndt Brandes, Rolf Angerbauer, Michael Lögers, Matthias Müller-Gliemann, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Joachim Schuhmacher, Henry Giera, Holger Paulsen, Paul Naab, Michael Conrad, Jürgen Stoltefuss
  • Cycloalkano-pyridines
    Patent number: 6069148
    Abstract: The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The, cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hyperlipoproteinaemia and arteriosclerosis.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: May 30, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Schmidt, Arndt Brandes, Rolf Angerbauer, Michael Logers, Matthias Muller-Gliemann, Carsten Schmeck, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Joachim Schuhmacher, Henry Giera, Holger Paulsen, Paul Naab, Michael Conrad, Jurgen Stoltefuss