Patents by Inventor Hollis Showalter

Hollis Showalter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Irreversible inhibitors of tyrosine kinases
    Patent number: 6344459
    Abstract: The present invention provides compounds that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that comprises a compound that is an irreversible inhibitor of tyrosine kinases.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: February 5, 2002
    Assignee: Warner-Lambert Company
    Inventors: Alexander James Bridges, William Alexander Denny, Ellen Myra Dobrusin, Annette Marian Doherty, David William Fry, Dennis Joseph McNamara, Howard Daniel Hollis Showalter, Jeffrey B. Smaill, Hairong Zhou
  • Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
    Patent number: 6218388
    Abstract: Benzimidazoles of Formula I below are inhibitors of protein tyrosine kinases, and are useful in treating cellular proliferation. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: April 17, 2001
    Assignee: Warner-Lambert Company
    Inventors: Diane Harris Boschelli, William Alexander Denny, Annette Marian Doherty, James Marino Hamby, Sonya Shah Khatana, James Bernard Kramer, Brian Desmond Palmer, Howard Daniel Hollis Showalter
  • Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation
    Patent number: 6150359
    Abstract: This invention relates to the inhibition of protein tyrosine kinase (PTK) and cell cycle kinase mediated cellular proliferation. More specifically, this invention relates to naphthyridinones and their use in inhibiting cellular proliferation and PTK or cell cycle kinase enzymatic activity.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: November 21, 2000
    Assignee: Warner-Lambert Company
    Inventors: Mark Robert Barvian, William Alexander Denny, Ellen Myra Dobrusin, James Marino Hamby, Howard Daniel Hollis Showalter, Andrew Mark Thompson, Roy Thomas Winters, Zhipei Wu
  • Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
    Patent number: 5990146
    Abstract: Benzimidazoles of Formula I below are inhibitors of protein tyrosine kinases, and are useful in treating cellular proliferation. ##STR1## The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.
    Type: Grant
    Filed: August 17, 1998
    Date of Patent: November 23, 1999
    Assignee: Warner-Lambert Company
    Inventors: Diane Harris Boschelli, William Alexander Denny, Annette Marian Doherty, James Marino Hamby, Sonya Shah Khatana, James Bernard Kramer, Brian Desmond Palmer, Howard Daniel Hollis Showalter
  • 6-aryl naphthyridines for inhibiting protein tyrosine kinase mediated cellular proliferation
    Patent number: 5952342
    Abstract: 6-Aryl naphthyridines are inhibitors of protein tyrosine kinase, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating atherosclerosis, restenosis, psoriasis, as well as bacterial infections.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: September 14, 1999
    Assignee: Warner-Lambert Company
    Inventors: Clifton John Blankley, Annette Marian Doherty, James Marino Hamby, Robert Lee Panek, Mel Conrad Schroeder, Howard Daniel Hollis Showalter, Cleo Connolly
  • 6-Aryl pyrido?2,3-d! pyrimidines and naphthyridines for inhibiting protein tyrosine kinase mediated cellular proliferation
    Patent number: 5733913
    Abstract: 6-Aryl pyrido?2,3-d!pyrimidines and naphthyridines are inhibitors of protein tyrosine kinase, and are thus useful in treating cellular proliferation mediated thereby. The compounds are especially useful in treating atherosclerosis, restenosis, psoriasis, as well as bacterial infections.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: March 31, 1998
    Inventors: Clifton John Blankley, Annette Marian Doherty, James Marino Hamby, Robert Lee Panek, Mel Conrad Schroeder, Howard Daniel Hollis Showalter, Cleo Connolly
  • Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
    Patent number: 5679683
    Abstract: Novel 4-substituted amino benzothieno?3,2-d!pyrimidine and 4-substituted amino?2,3-d!pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinases are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: October 21, 1997
    Assignee: Warner-Lambert Company
    Inventors: Alexander James Bridges, William Alexander Denny, David Fry, Alan Kraker, Robert Frederick Meyer, Gordon William Rewcastle, Andrew Mark Thompson, Howard Daniel Hollis Showalter
  • Chiral [[(2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazol-1-ethanol and related compounds
    Patent number: 5659048
    Abstract: Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: August 19, 1997
    Assignees: British Technology Group Limited, Warner-Lambert Company
    Inventors: Vladimir Genukh Beylin, Anthony Denver Sercel, Howard Daniel Hollis Showalter, Gerald Edward Adams, Edward Martin Fielden, Matthew Alexander Naylor, Ian James Stratford
  • Process for preparing substituted anthra[1,9-cd]pyrazol-6(2H)-ones
    Patent number: 4672129
    Abstract: An improved process for producing anthra[1,9-cd]-pyrazol-6(2H)-ones from 1,4-dichloro-5,8-disubstituted 9,10-anthracenediones. The process produces higher yields by using a new combination of protecting groups on the compounds which allows for easier and cleaner chromatographic resolution. The compounds produced have antibacterial, antifungal, antileukemic, and antitumor activity.
    Type: Grant
    Filed: May 5, 1986
    Date of Patent: June 9, 1987
    Assignee: Warner-Lambert Company
    Inventors: Vladimir G. Beylin, Om P. Goel, H.D. Hollis Showalter