Abstract: A two plane self-balancing centrifuge is disclosed herein in which the centrifuge rotor is driven by a shaft attached to bearings. The bearings are supported by upper and lower flexible bearing mounts. This results in two horizontally flexible bearing mounting planes to provide a greater degree of freedom for the axis of rotation of the rotor to move into a coincident relationship with the angular momentum vector of the rotor as it changes with dynamic imbalance thereby to compensate for any imbalance which may occur in the centrifuge rotor during processing. The centrifuge particularly suited for use in processing blood.