Patents by Inventor Holly Dressler

Holly Dressler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSGENIC NON-HUMAN ANIMAL AND USES THEREOF
    Publication number: 20150208623
    Abstract: The present invention relates generally to transgene constructs, transgenic non-human animals comprising transgene constructs, methods of making and methods of using the transgenic non-human animals comprising transgene constructs. An embodiment of the invention relates to methods of assaying the activation of GPCR ligands non-invasively in whole animals, tissue slices, or in native cells using a transgenic model containing a bioluminescent transgene reporter system that is responsive to pathway following ligand binding of GPCR receptors.
    Type: Application
    Filed: February 4, 2015
    Publication date: July 30, 2015
    Applicant: SANOFI
    Inventors: Holly DRESSLER, Kyriakos D. ECONOMIDES, Zhen PANG, Harry Gregory POLITES
  • Transgenic non-human animal and uses thereof
    Patent number: 8981179
    Abstract: The present invention relates generally to transgene constructs, transgenic non-human animals comprising transgene constructs, methods of making and methods of using the transgenic non-human animals comprising transgene constructs. An embodiment of the invention relates to methods of assaying the activation of GPCR ligands non-invasively in whole animals, tissue slices, or in native cells using a transgenic model containing a bioluminescent transgene reporter system that is responsive to pathway modulation following ligand binding of GPCR receptors.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: March 17, 2015
    Assignee: Sanofi
    Inventors: Holly Dressler, Kyriakos D. Economides, Zhen Pang, Harry Gregory Polites
  • TRANSGENIC NON-HUMAN ANIMAL AND USES THEREOF
    Publication number: 20120255041
    Abstract: The present invention relates generally to transgene constructs, transgenic non-human animals comprising transgene constructs, methods of making and methods of using the transgenic non-human animals comprising transgene constructs. An embodiment of the invention relates to methods of assaying the activation of GPCR ligands non-invasively in whole animals, tissue slices, or in native cells using a transgenic model containing a bioluminescent transgene reporter system that is responsive to pathway modulation following ligand binding of GPCR receptors.
    Type: Application
    Filed: December 17, 2010
    Publication date: October 4, 2012
    Applicant: SANOFI
    Inventors: Holly Dressler, Kyriakos D. Economides, Zhen Pang, Harry Gregory Polites
  • Nucleic acid encoding a G-protein-coupled receptor, and uses thereof
    Publication number: 20030166008
    Abstract: Provided herein is a novel and useful G-protein coupled receptor that is involved in signal transduction with respect to inflammation and physiological immunological response. Also provided are methods of using the receptor to screen for molecules that may modulate the activity of the receptor. Such molecules may readily have applications in treating a plethora of inflammation and immunologically related diseases and disorders.
    Type: Application
    Filed: February 13, 2003
    Publication date: September 4, 2003
    Inventors: Haifeng Eishingdrelo, Holly Dressler, Jidong Cai, Paul Wright