Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting PMP22 expression and for treating, preventing, or ameliorating a disease associated with PMP22.

Abstract: Embodiments of the present disclosure are directed to portable facial treatment devices, and methods of using same. In some embodiments, the invention is directed to a muscle toning treatment device, comprising: (i) a polarity generator; (ii) a single active electrode assembly comprising a first electrode being adapted to apply electrical current to the area of the skin to be treated; (iii) at least one vibration modality, wherein the vibration modality provides a vibration frequency, of between 5-6 MHz or between 30-35 Hz; (iv) at least one heating modality for heating the skin of the user, wherein the temperature of the heating modality is between 34 and 45 degrees Celsius; and (v) a counter electrode assembly comprising second electrode being adapted to be in continuous contact to a second location of the skin of the user.