Patents by Inventor Holly MAULHARDT

Holly MAULHARDT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer
    Patent number: 11918691
    Abstract: Disclosed are combination therapy methods useful for the therapeutic treatment of cancer by combining local administration of compositions containing antineoplastic particles, such as taxane particles, with systemic administration of compositions containing immunotherapeutic agents. Local administration methods include topical application, pulmonary administration, intratumoral injection, intraperitoneal injection, arid intracystic injection.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: March 5, 2024
    Assignee: CRITITECH, INC.
    Inventors: Gere S. Dizerega, Michael Baltezor, Sam Campbell, Charles J. Decedue, Matthew McClorey, Holly Maulhardt
  • Treatment of Epithelial Cysts by Intracystic Injection of Antineoplastic Particles
    Publication number: 20230372234
    Abstract: Disclosed herein are methods for treating epithelial cysts, including pancreatic cysts, in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.
    Type: Application
    Filed: July 13, 2023
    Publication date: November 23, 2023
    Inventors: Gere S. diZerega, Michael Baltezor, Charles J. Decedue, Sam Campbell, Matthew McClorey, Marc Iacobucci, Holly Maulhardt
  • Treatment of epithelial cysts by intracystic injection of antineoplastic particles
    Patent number: 11737972
    Abstract: Disclosed herein are methods for treating epithelial cysts, including pancreatic cysts, in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.
    Type: Grant
    Filed: October 12, 2022
    Date of Patent: August 29, 2023
    Assignee: CRITITECH, INC.
    Inventors: Gere S. diZerega, Michael Baltezor, Charles J. Decedue, Sam Campbell, Matthew McClorey, Marc Iacobucci, Holly Maulhardt
  • Treatment of Epithelial Cysts by Intracystic Injection of Antineoplastic Particles
    Publication number: 20230111288
    Abstract: Disclosed herein are methods for treating epithelial cysts, including pancreatic cysts, in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.
    Type: Application
    Filed: October 12, 2022
    Publication date: April 13, 2023
    Inventors: Gere S. diZerega, Michael Baltezor, Charles J. Decedue, Sam Campbell, Matthew McClorey, Marc Iacobucci, Holly Maulhardt
  • Treatment of epithelial cysts by intracystic injection of antineoplastic particles
    Patent number: 11523983
    Abstract: Disclosed herein are methods for treating epithelial cysts, including pancreatic cysts, in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: December 13, 2022
    Assignee: CritiTech, Inc.
    Inventors: Gere S. diZerega, Michael Baltezor, Charles J. Decedue, Sam Campbell, Matthew McClorey, Marc Iacobucci, Holly Maulhardt
  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20220331261
    Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.
    Type: Application
    Filed: March 17, 2022
    Publication date: October 20, 2022
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE
  • Delivery of drug nanoparticles and methods of use thereof
    Patent number: 11331278
    Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 17, 2022
    Assignee: DFB SORIA, LLC
    Inventors: Keith Johnson, Robert Lathrop, Meidong Yang, Holly Maulhardt, Roland Franke
  • Treatment of Epithelial Cysts by Intracystic Injection of Antineoplastic Particles
    Publication number: 20210259959
    Abstract: Disclosed herein are methods for treating epithelial cysts, including pancreatic cysts, in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.
    Type: Application
    Filed: May 10, 2021
    Publication date: August 26, 2021
    Inventors: Gere S. diZerega, Michael Baltezor, Charles J. Decedue, Sam Campbell, Matthew McClorey, Marc Iacobucci, Holly Maulhardt
  • METHODS FOR ISOLATING TUMOR-SPECIFIC IMMUNE CELLS FROM A SUBJECT FOR ADOPTIVE CELL THERAPY AND CANCER VACCINES
    Publication number: 20210214683
    Abstract: Disclosed are methods for the isolation of tumor-specific immune cells from subjects that have a malignant tumor and have received local administration of a composition comprising taxane particles to the malignant tumor, and use of such isolated immune cells in compositions for adoptive cell therapy and cancer vaccines.
    Type: Application
    Filed: April 12, 2019
    Publication date: July 15, 2021
    Inventors: Gere S. DIZEREGA, Holly MAULHARDT, Michael BALTEZOR, Sam CAMPBELL, Charles J. DECEDUE, William JOHNSTON, Matthew MCCLOREY, James VERCO
  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20210106539
    Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.
    Type: Application
    Filed: December 4, 2020
    Publication date: April 15, 2021
    Applicant: DFB Soria, LLC
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE
  • Delivery of drug nanoparticles and methods of use thereof
    Patent number: 10918606
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: February 16, 2021
    Assignee: DFB Soria, LLC
    Inventors: Keith Johnson, Robert Lathrop, Meidong Yang, Holly Maulhardt, Roland Franke
  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20200069600
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Application
    Filed: September 11, 2019
    Publication date: March 5, 2020
    Applicant: DFB Soria, LLC
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE
  • Methods for Isolating Tumor-Specific Immune Cells from a Subject for Adoptive Cell Therapy and Cancer Vaccines
    Publication number: 20190365700
    Abstract: Disclosed are methods for the isolation of tumor-specific immune cells from subjects that have a malignant tumor and have received local administration of a composition comprising taxane particles to the malignant tumor, and use of such isolated immune cells in compositions for adoptive cell therapy and cancer vaccines.
    Type: Application
    Filed: April 12, 2019
    Publication date: December 5, 2019
    Inventors: Gere S. Dizerega, Holly Maulhardt, Michael Baltezor, Sam Campbell, Charles J. Decedue, William Johnston, Matthew McClorey, James Verco
  • Treatment of Kidney Tumors by Intratumoral Injection of Taxane Particles
    Publication number: 20190365699
    Abstract: Disclosed herein are compositions and methods for treating kidney tumors by intratumoral injection administration of compositions comprising taxane particles such as docetaxel particles or paclitaxel particles.
    Type: Application
    Filed: January 4, 2019
    Publication date: December 5, 2019
    Inventors: Michael BALTEZOR, Gere DIZEREGA, Charles J. DECEDUE, Sam CAMPBELL, Matthew MCCLOREY, Holly MAULHARDT
  • Delivery of drug nanoparticles and methods of use thereof
    Patent number: 10449162
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: October 22, 2019
    Assignee: DFB Soria LLC
    Inventors: Keith Johnson, Robert Lathrop, Meidong Yang, Holly Maulhardt, Roland Franke
  • Treatment of Epithelial Cysts by Intracystic Injection of Antineoplastic Particles
    Publication number: 20190254957
    Abstract: Disclosed herein are methods for treating epithelial cysts including pancreatic cysts in a subject by intracystic injection of compositions comprising antineoplastic particles, including taxane particles such as paclitaxel particles and docetaxel particles.
    Type: Application
    Filed: April 12, 2019
    Publication date: August 22, 2019
    Inventors: Gere S. diZerega, Michael Baltezor, Charles J. Decedue, Sam Campbell, Matthew McClorey, Marc Iacobucci, Holly Maulhardt
  • DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20180177739
    Abstract: Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.
    Type: Application
    Filed: February 19, 2018
    Publication date: June 28, 2018
    Applicant: DFB Soria, LLC
    Inventors: Keith JOHNSON, Robert LATHROP, Meidong YANG, Holly MAULHARDT, Roland FRANKE