Patents by Inventor Holly Sofka

Holly Sofka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable reactive compositions for bioconjugation, probes, and protein labeling
    Patent number: 12741986
    Abstract: Modular Meldrum's acid amine-reactive Michael acceptor (MaMa)—based molecules that are stable probes for high pH environments and bioconjugations. The molecules of the present invention can selectively label and protect lysine residues. In certain embodiments, the molecules can selectively react with lysine at particular pH levels. The probes of the present invention may be used to label proteins in a fluorescent manner, for purification, imaging, or general protein modifications, however the present invention is not limited to the aforementioned applications.
    Type: Grant
    Filed: March 15, 2021
    Date of Patent: September 22, 2026
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: John C. Jewett, Garrett Davis, Holly Sofka
  • STABLE REACTIVE COMPOSITIONS FOR BIOCONJUGATION, PROBES, AND PROTEIN LABELING
    Publication number: 20230111712
    Abstract: Modular Meldrum's acid amine-reactive Michael acceptor (MaMa)—based molecules that are stable probes for high pH environents and bioconjugations. The molecules of the present invention can selectively label and protect lysine residues. In certain embodiments, the molecules can selectively react with lysine at particular pH levels. The probes of the present invention may be used to label proteins in a fluorescent manner, for purification, imaging, or general protein modifications, however the present invention is not limited to the aforementioned applications.
    Type: Application
    Filed: March 15, 2021
    Publication date: April 13, 2023
    Inventors: John C. Jewett, Garrett Davis, Holly Sofka