Patents by Inventor Homayoun Vaziri
Homayoun Vaziri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8546074Abstract: Methods for screening a compound, by providing a test mixture comprising a transcription factor, Sir2, and a Sir2 cofactor with the compound, and evaluating an activity of a component of the test mixture in the presence of the compound are described.Type: GrantFiled: June 14, 2012Date of Patent: October 1, 2013Assignees: Massachusetts Institute of Technology, Whitehead Institute for Biomedical ResearchInventors: Leonard P. Guarente, Homayoun Vaziri, Shin-Ichiro Imai
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Publication number: 20130071378Abstract: Methods for screening a compound, by providing a test mixture comprising a transcription factor, Sir2, and a Sir2 cofactor with the compound, and evaluating an activity of a component of the test mixture in the presence of the compound are described.Type: ApplicationFiled: June 14, 2012Publication date: March 21, 2013Inventors: Leonard Guarente, Homayoun Vaziri, Shin-Ichiro Imai
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Publication number: 20100105036Abstract: This invention relates to methods of screening compounds that modulate cellular and organismal processes by modification of the activity of SIR2 and/or transcription factors, e.g., p53, particularly methods of screening for compounds that modify lifespan and/or metabolism of a cell or an organism by modulation of the activity of SIR2 and/or transcription factors, e.g., p53, and more particularly to methods of screening for compounds that modulate the activity of Sir2 and/or transcription factors, e.g., p53. In particular, the present invention relates to a method for screening a compound, by providing a test mixture comprising a transcription factor, Sir2, and a Sir2 cofactor with the compound, and evaluating an activity of a component of the test mixture in the presence of the compound. The invention further relates to therapeutic uses of said compounds.Type: ApplicationFiled: March 20, 2009Publication date: April 29, 2010Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCHInventors: Leonard Guarente, Homayoun Vaziri, Shin-Ichiro Imai
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Patent number: 7572575Abstract: This invention relates to methods of screening compounds that modulate cellular and organismal processes by modification of the activity of SIR2 and/or transcription factors, e.g., p53, particularly methods of screening for compounds that modify lifespan and/or metabolism of a cell or an organism by modulation of the activity of SIR2 and/or transcription factors, e.g., p53, and more particularly to methods of screening for compounds that modulate the activity of Sir2 and/or transcription factors, e.g., p53. In particular, the present invention relates to a method for screening a compound, by providing a test mixture comprising a transcription factor, Sir2, and a Sir2 cofactor with the compound, and evaluating an activity of a component of the test mixture in the presence of the compound. The invention further relates to therapeutic uses of said compounds.Type: GrantFiled: April 13, 2006Date of Patent: August 11, 2009Assignees: Massachusetts Institute of Technology, Whitehead Institute for Biomedical ResearchInventors: Leonard Guarente, Homayoun Vaziri, Shin-Ichiro Imai
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Publication number: 20060252076Abstract: This invention relates to methods of screening compounds that modulate cellular and organismal processes by modification of the activity of SIR2 and/or transcription factors, e.g., p53, particularly methods of screening for compounds that modify lifespan and/or metabolism of a cell or an organism by modulation of the activity of SIR2 and/or transcription factors, e.g., p53, and more particularly to methods of screening for compounds that modulate the activity of Sir2 and/or transcription factors, e.g., p53. In particular, the present invention relates to a method for screening a compound, by providing a test mixture comprising a transcription factor, Sir2, and a Sir2 cofactor with the compound, and evaluating an activity of a component of the test mixture in the presence of the compound. The invention further relates to therapeutic uses of said compounds.Type: ApplicationFiled: April 13, 2006Publication date: November 9, 2006Applicant: Massachusetts Institute of TechnologyInventors: Leonard Guarente, Homayoun Vaziri, Shin-Ichiro Imai
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Publication number: 20040005574Abstract: This invention relates to methods of screening compounds that modulate cellular and organismal processes by modification of the activity of SIR2 and/or transcription factors, e.g., p53, particularly methods of screening for compounds that modify lifespan and/or metabolism of a cell or an organism by modulation of the activity of SIR2 and/or transcription factors, e.g., p53, and more particularly to methods of screening for compounds that modulate the activity of Sir2 and/or transcription factors, e.g., p53. In particular, the present invention relates to a method for screening a compound, by providing a test mixture comprising a transcription factor, Sir2, and a Sir2 cofactor with the compound, and evaluating an activity of a component of the test mixture in the presence of the compound. The invention further relates to therapeutic uses of said compounds.Type: ApplicationFiled: July 8, 2002Publication date: January 8, 2004Inventors: Leonard Guarente, Homayoun Vaziri, Shin-Ichiro Imai
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Publication number: 20030190638Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: ApplicationFiled: August 29, 2002Publication date: October 9, 2003Applicant: Board of Regents, The University of Texas SystemInventors: Michael D. West, Calvin B. Harley, Scott L. Weinrich, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Nam Woo Kim, Homayoun Vaziri
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Patent number: 6551774Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: GrantFiled: August 20, 1999Date of Patent: April 22, 2003Assignees: Board of Regents, The University of Texas System, The Regents of the University of California, Geron CorporationInventors: Michael D. West, Calvin B. Harley, Scott L. Weinrich, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Nam Woo Kim, Homayoun Vaziri
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Patent number: 6007989Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: GrantFiled: March 14, 1997Date of Patent: December 28, 1999Assignees: Board of Regents, The University of Texas System, The Regents of the University of California, Geron CorporationInventors: Michael D. West, Calvin B. Harley, Scott L. Weinrich, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Nam Woo Kim, Homayoun Vaziri
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Patent number: 5645986Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.Type: GrantFiled: November 12, 1993Date of Patent: July 8, 1997Assignees: Board of Reagents, The University of Texas System, The Reagents of the University of California, Geron CorporationInventors: Michael D. West, Calvin B. Harley, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Homayoun Vaziri