Patents by Inventor Homer L. Pearce

Homer L. Pearce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical Entities, Pharmaceutical Formulations, and Methods for Treating Fibrosis
    Publication number: 20200354374
    Abstract: Disclosed herein are chemical entities, or pharmaceutically acceptable salts thereof, for treating fibrosis, including pulmonary fibrosis, such as idiopathic pulmonary fibrosis. Also disclosed herein are pharmaceutical formulations for treating fibrosis, the pharmaceutical formulations including one or more of the foregoing chemical entities and one or more pharmaceutically acceptable excipients, carriers, vehicles, or a combination thereof. Also disclosed herein are packaged pharmaceutical formulations for treating fibrosis, the packaged pharmaceutical formulations including one of the foregoing pharmaceutical formulations and instructions for using the pharmaceutical formulation to treat a patient having fibrosis or susceptible to fibrosis. Also disclosed herein is a method for treating fibrosis, the method including administering one of the foregoing pharmaceutical formulations.
    Type: Application
    Filed: May 5, 2020
    Publication date: November 12, 2020
    Inventor: Homer L. Pearce
  • 5-deaza-10-oxo-and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids
    Patent number: 5552545
    Abstract: 5-Deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acid derivatives are provided as agents useful for treating susceptible neoplasms in mammals. Pharmaceutical formulations and intermediates are also provided.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: September 3, 1996
    Assignee: Eli Lilly and Company
    Inventors: Homer L. Pearce, Mark A. Winter
  • 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids
    Patent number: 5321150
    Abstract: 5-Deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acid derivatives are provided as agents useful for treating susceptible neoplasms in mammals. Pharmaceutical formulations and intermediates are also provided.
    Type: Grant
    Filed: July 7, 1992
    Date of Patent: June 14, 1994
    Assignee: Eli Lilly and Company
    Inventors: Homer L. Pearce, Mark A. Winter
  • 2-piperidones as intermediates for 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids
    Patent number: 5159079
    Abstract: 4-Deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acid derivatives are provided as agents useful for treatment susceptible neoplasms in mammals. Pharmaceutical formulations and intermediates are also provided.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: October 27, 1992
    Assignee: Eli Lilly and Company
    Inventors: Homer L. Pearce, Mark A. Winter
  • 12'-Iodo derivatives of dimeric indole-dihydroindole alkaloids, and process for preparing them
    Patent number: 4430269
    Abstract: 12'-Iodo VLB, and related 5-iodo-2,3-disubstituted indoles; and a method for their preparation.
    Type: Grant
    Filed: April 1, 1982
    Date of Patent: February 7, 1984
    Assignee: Eli Lilly and Company
    Inventor: Homer L. Pearce
  • Method of preparing vincristine
    Patent number: 4303584
    Abstract: Vincristine is prepared from VLB sulfate or free base by oxidation with an acidic ferrous perchloratehydrogen peroxide oxidation reagent at about -30.degree. C.
    Type: Grant
    Filed: April 2, 1980
    Date of Patent: December 1, 1981
    Assignee: Eli Lilly and Company
    Inventor: Homer L. Pearce