Patents by Inventor Hon Li

Hon Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220387356
    Abstract: Provided herein are plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The disclosure includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.
    Type: Application
    Filed: August 8, 2022
    Publication date: December 8, 2022
    Inventors: Daniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li
  • Patent number: 11426368
    Abstract: Provided herein are plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The disclosure includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: August 30, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITY
    Inventors: Daniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li
  • Publication number: 20170291893
    Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.
    Type: Application
    Filed: June 27, 2017
    Publication date: October 12, 2017
    Inventors: Daniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li, Mark Warnock, Gregory Abernathy
  • Patent number: 9718760
    Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: August 1, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITY
    Inventors: Daniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li, Mark Warnock, Gregory Abernathy
  • Patent number: 9527878
    Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: December 27, 2016
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITY
    Inventors: Daniel A. Lawrence, Cory Emal, Jacqueline Cale, Enming Joe Su, Mark Warnock, Shih-Hon Li, Jeanne Ann Cupp
  • Publication number: 20160009748
    Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
    Type: Application
    Filed: August 4, 2015
    Publication date: January 14, 2016
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITY
    Inventors: Daniel A. Lawrence, Cory Emal, Jacqueline Cale, Enming Joe Su, Mark Warnock, Shih-Hon Li, Jeanne Ann Cupp
  • Publication number: 20150315178
    Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.
    Type: Application
    Filed: October 31, 2013
    Publication date: November 5, 2015
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITY
    Inventors: Daniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li, Mark Warnock, Gregory Abernathy
  • Patent number: 9120744
    Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: September 1, 2015
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITY
    Inventors: Daniel A. Lawrence, Cory Emal, Jacqueline Cale, Enming J. Su, Mark Warnock, Shih-Hon Li, Jeanne A. Cupp
  • Patent number: 8352263
    Abstract: The invention can recognize all languages and input words. It needs m unknown voices to represent m categories of known words with similar pronunciations. Words can be pronounced in any languages, dialects or accents. Each will be classified into one of m categories represented by its most similar unknown voice. When user pronounces a word, the invention finds its F most similar unknown voices. All words in F categories represented by F unknown voices will be arranged according to their pronunciation similarity and alphabetic letters. The pronounced word should be among the top words. Since we only find the F most similar unknown voices from m (=500) unknown voices and since the same word can be classified into several categories, our recognition method is stable for all users and can fast and accurately recognize all languages (English, Chinese and etc.) and input much more words without using samples.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: January 8, 2013
    Inventors: Tze-Fen Li, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
  • Publication number: 20120116764
    Abstract: A speech recognition method on all sentences in all languages is provided. A sentence can be a word, name or sentence. All sentences are represented by E×P=12×12 matrices of linear predict coding cepstra (LPCC) 1000 different voices are transformed into 1000 matrices of LPCC to represent 1000 databases. E×P matrices of known sentences after deletion of time intervals between two words are put into their closest databases. To classify an unknown sentence, use the distance to find its F closest databases and then from known sentences in its F databases, find a known sentence to be the unknown one. The invention needs no samples and can find a sentence in one second using Visual Basic. Any person without training can immediately and freely communicate with computer in any language. It can recognize up to 7200 English words, 500 sentences of any language and 500 Chinese words.
    Type: Application
    Filed: November 9, 2010
    Publication date: May 10, 2012
    Inventors: Tze Fen Li, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
  • Patent number: 8160866
    Abstract: The present invention can recognize both English and Chinese at the same time. The most important skill is that the features of all English words (without samples) are entirely extracted from the features of Chinese syllables. The invention normalizes the signal waveforms of variable lengths for English words (Chinese syllables) such that the same words (syllables) can have the same features at the same time position. Hence the Bayesian classifier can recognize both the fast and slow utterance of sentences. The invention can improve the feature such that the speech recognition of the unknown English (Chinese) is guaranteed to be correct. Furthermore, since the invention can create the features of English words from the features of Chinese syllables, it can also create the features of other languages from the features of Chinese syllables and hence it can also recognize other languages, such as German, French, Japanese, Korean, Russian, etc.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: April 17, 2012
    Inventors: Tze Fen Li, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
  • Patent number: 8145483
    Abstract: The invention can recognize any several languages at the same time without using samples. The important skill is that features of known words in any language are extracted from unknown words or continuous voices. These unknown words represented by matrices are spread in the 144-dimensional space. The feature of a known word of any language represented by a matrix is simulated by the surrounding unknown words. The invention includes 12 elastic frames of equal length without filter and without overlap to normalize the signal waveform of variable length for a word, which has one to several syllables, into a 12×12 matrix as a feature of the word. The invention can improve the feature such that the speech recognition of an unknown sentence is correct. The invention can correctly recognize any languages without samples, such as English, Chinese, German, French, Japanese, Korean, Russian, Cantonese, Taiwanese, etc.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: March 27, 2012
    Inventors: Tze Fen Li, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
  • Publication number: 20110066434
    Abstract: The invention can recognize all languages and input words. It needs m unknown voices to represent m categories of known words with similar pronunciations. Words can be pronounced in any languages, dialects or accents. Each will be classified into one of m categories represented by its most similar unknown voice. When user pronounces a word, the invention finds its F most similar unknown voices. All words in F categories represented by F unknown voices will be arranged according to their pronunciation similarity and alphabetic letters. The pronounced word should be among the top words. Since we only find the F most similar unknown voices from m (=500) unknown voices and since the same word can be classified into several categories, our recognition method is stable for all users and can fast and accurately recognize all languages (English, Chinese and etc.) and input much more words without using samples.
    Type: Application
    Filed: September 29, 2009
    Publication date: March 17, 2011
    Inventors: Tze-Fen LI, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
  • Publication number: 20110035216
    Abstract: The invention can recognize any several languages at the same time without using samples. The important skill is that features of known words in any language are extracted from unknown words or continuous voices. These unknown words represented by matrices are spread in the 144-dimensional space. The feature of a known word of any language represented by a matrix is simulated by the surrounding unknown words. The invention includes 12 elastic frames of equal length without filter and without overlap to normalize the signal waveform of variable length for a word, which has one to several syllables, into a 12×12 matrix as a feature of the word. The invention can improve the feature such that the speech recognition of an unknown sentence is correct. The invention can correctly recognize any languages without samples, such as English, Chinese, German, French, Japanese, Korean, Russian, Cantonese, Taiwanese, etc.
    Type: Application
    Filed: August 5, 2009
    Publication date: February 10, 2011
    Inventors: Tze Fen LI, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
  • Publication number: 20100137194
    Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
    Type: Application
    Filed: November 23, 2009
    Publication date: June 3, 2010
    Applicants: EASTERN MICHIGAN UNIVERSITY
    Inventors: Daniel A. Lawrence, Cory Emal, Jacqueline Cale, Enming J. Su, Mark Warnock, Shih-Hon Li, Jeanne A. Cupp
  • Publication number: 20090265159
    Abstract: The present invention can recognize both English and Chinese at the same time. The most important skill is that the features of all English words (without samples) are entirely extracted from the features of Chinese syllables. The invention normalizes the signal waveforms of variable lengths for English words (Chinese syllables) such that the same words (syllables) can have the same features at the same time position. Hence the Bayesian classifier can recognize both the fast and slow utterance of sentences. The invention can improve the feature such that the speech recognition of the unknown English (Chinese) is guaranteed to be correct. Furthermore, since the invention can create the features of English words from the features of Chinese syllables, it can also create the features of other languages from the features of Chinese syllables and hence it can also recognize other languages, such as German, French, Japanese, Korean, Russian, etc.
    Type: Application
    Filed: October 10, 2008
    Publication date: October 22, 2009
    Inventors: Tze-Fen LI, Tai-Jan Lee Li, Shih-Tzung Li, Shih-Hon Li, Li-Chuan Liao
  • Publication number: 20080241433
    Abstract: An artificial hedge structure (10) comprising at least two panels, with each panel having a multiplicity of equidistant vertical members (26) and a multiplicity of equidistant horizontal spacers (28). A hinge assembly (44) comprising four hinge tabs (46), a hinge pin (50) and vertical spacers (52) is located between a first panel (12) and a second panel (42). The hinge assembly (44) allows the two panels to be positioned at an angle to each other, and allows multiple panels to be positioned in various shapes such as square or circular. Integrally attached to each panel's vertical member (26) and extending outward from the front and rear surfaces (78,80) are a multiplicity of needle clusters (60). Each cluster (60) has a plurality of resilient needles (66) that extend upward from a lower surface (62). Extending into the lower surface (62) is a cavity (64) that interfaces with a pin (40) that extends outward from the vertical members (26).
    Type: Application
    Filed: March 30, 2007
    Publication date: October 2, 2008
    Inventor: Wing Hon Li
  • Publication number: 20080176482
    Abstract: A decorative structure (10) comprising a body section (12), a head section (14), at least two appendage sections (16), and a multiplicity of body fur clusters (18). The body section (12), head section (14) and at least two appendage sections (16) are each formed over a three-dimensional lattice frame (20) that is constructed of a multiplicity of longitudinal members (24) that are spaced by a multiplicity of integral lateral member (22). Extending outward from the three-dimensional lattice frames (20) are a multiplicity of pins (28). Each body fur cluster (18) is comprised of a lower surface (34) having a cavity (36), and a plurality of resilient needles (38) that extend upward from the lower surface (34). The upward-extending pins (28) are designed to frictionally fit into the cavity (36) on the lower surface (34). Once all the clusters (18) are attached to the pins (28), the structure (10) will have an enveloping fur-like appearance.
    Type: Application
    Filed: January 22, 2007
    Publication date: July 24, 2008
    Inventor: Wing Hon Li
  • Patent number: 6004635
    Abstract: An artificial plant assembly (10) that includes a base (12) which serves as a platform for securing the assembly (10) when it is inserted into a vase or the like. The base (10) which can be made in a variety of geometrical shapes such as a circle, a square or a multi-sided shape includes a central stem bore (18) and a plurality of outer stem bores (20). Into the bore (18) is inserted a central stem support (30) which has an upper edge (38) which includes a plurality of inner stem bores (42). Around the central stem support (30) is located, in a random or symmetrical pattern, a plurality of outer stem bores (20). Into the bores (20 and (42) is inserted an inner core (62) into which is inserted one or a plurality of nested and rotatable bulbous sections (70, 92, 102). Each bulbous section has an upper end which terminates with a flora (84) which may consist of a flower of leaf or a combination of various flora.
    Type: Grant
    Filed: April 20, 1998
    Date of Patent: December 21, 1999
    Inventor: Wing Hon Li
  • Patent number: 5759645
    Abstract: An artificial plant assembly (10) consisting of a stationary central stem (12) and a plurality of rotatable fronds (70). The central stem (12) includes a rigid inner core (14) and a molded outer stem (22). Near the lower terminus (26) of the outer stem (22) is a frond stop (30), a bulbous section (48) located above the stop (30), and extending from the upper end (18) and sides is located a plurality of leaves (58). The rotatable frond (70) also has a rigid inner core (72) and a molded outer stem (80). The outer stem (80) has an upper terminus (82), a lower bulbous section (84), and a plurality of leaves (58) that extend from its upper terminus (82) and sides. The lower bulbous section (84) has an open side (86) and an enclosed lower portion (80) having an opening (90). To produce the artificial plant assembly (10) the lower bulbous section (84) is inserted upward through the lower end (16) of the inner core (14) and forced over the frond stop (30).
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: June 2, 1998
    Inventor: Wing Hon Li