Abstract: A magnetism characteristic detection method, a magnetism characteristic detection apparatus, an imaging apparatus and an imaging method are provided, where magnetism detection and imaging are based on an integrated excitation field of a direct current (DC) magnetic field and an oscillation wave. The magnetism detection method includes the following steps. A DC magnetic field is selectively applied to an object. Further, an oscillation wave is provided to the object, where the oscillation wave is a sound wave or an ultrasound wave. Then, a magnetism characteristic variation of the object is detected.

Abstract: A magnetism characteristic detection method, a magnetism characteristic detection apparatus, an imaging apparatus and an imaging method are provided, where magnetism detection and imaging are based on an integrated excitation field of a direct current (DC) magnetic field and an oscillation wave. The magnetism detection method includes the following steps. A DC magnetic field is selectively applied to an object. Further, an oscillation wave is provided to the object, where the oscillation wave is a sound wave or an ultrasound wave. Then, a magnetism characteristic variation of the object is detected.

Abstract: The invention provides a low-field nuclear magnetic resonance system for measuring a magnetic resonance signal of an object. The low-field nuclear magnetic resonance system includes a pre-magnetization module, a uniform magnetic field coil module, a pulse and receiving coil module, a filter amplifier module, a signal acquisition module and a processing module. The pre-magnetization module is used to establish a pre-magnetization field in the object to increase magnetization of the object. The uniform magnetic field coil module is used to change a resonance frequency and background magnetic field intensity of the object during nuclear magnetic resonance measurement by regulating a magnetic field of the coil. The processing module further includes a programming object for controlling timing processing and signal analysis of the measurement process.

Abstract: The invention provides a high resolution proton nuclear magnetic reonance and imaging (NMR/MRI) in microtesla magnetic fields by using high critical temperature (high-Tc) superconducting quantum interference device (SQUID) magnetometer via a flux transformer. Both the SQUID and the input coupling coil are installed inside a superconducting vessel which shields environmental noise and set the SQUID in a stable operation condition. The present invention also offers the advantages of preserving the NMR signal even if the sample is far away from the SQUID detector.

Abstract: Disclosed is an apparatus for measuring ac magnetization at mixture frequency. The apparatus includes an ac generating unit for generating at least a first current with a frequency f1 and a second current with a frequency f2. The apparatus further includes a co-axial solenoid unit, driven by the first and second ac currents, to generate a first magnetic field and a second magnetic field. A pick-up solenoid is for disposing sample for detecting an ac magnetization of the sample and multiple frequency-component signals corresponding to various frequency combinations of f1 and f2 are output. The apparatus further includes a signal processing circuit for receiving the frequency-component signals, where the signal processing circuit obtains the ac magnetization of the sample at a target frequency of (?Tf1+?Tf2), which ?T and ?T are positive integers and the frequency f1 and the frequency f2 are two different frequencies.

Abstract: The invention provides a low-field nuclear magnetic resonance system for measuring a magnetic resonance signal of an object. The low-field nuclear magnetic resonance system includes a pre-magnetization module, a uniform magnetic field coil module, a pulse and receiving coil module, a filter amplifier module, a signal acquisition module and a processing module. The pre-magnetization module is used to establish a pre-magnetization field in the object to increase magnetization of the object. The uniform magnetic field coil module is used to change a resonance frequency and background magnetic field intensity of the object during nuclear magnetic resonance measurement by regulating a magnetic field of the coil. The processing module further includes a programming object for controlling timing processing and signal analysis of the measurement process.

Abstract: A method for suppressing non-specific bindings between molecules includes providing magnetic particles dispersed in a liquid, wherein each of the magnetic particles has a magnetization. The magnetic particles are coated with coating molecules. Binding molecules mixed of first-type binding molecules and second-type binding molecules are applied to the liquid, wherein the coating molecules are specifically binding with the first-type binding molecules and non-specifically binding with the second-type binding molecules. An alternating current (ac) magnetic field is applied at an axis with a frequency level, wherein the frequency level causes suppression of the second-type binding molecules in binding with the coating molecules.

Abstract: An ultra-sensitive, wash-free method for quantitatively determining the concentration of biomolecules in a sample solution is provided. The sensitivity of the method is 1 ppt or below. The method includes providing a reagent containing magnetic nanoparticles and measuring the ac magnetic susceptibility of the reagent. Then, a sample solution containing either multiple-active epitope biomolecules or single-active-epitope biomolecules is mixed with the reagent. The ac magnetic susceptibility of the reagent after the association with the biomolecules is measured. Thereafter, the difference in the ac magnetic susceptibility of the reagent before and after the association with the biomolecules is measured and the concentration of biomolecules in the sample solution is determined.

Abstract: The present invention provides a method for rapid detecting tumor. Moreover, this invention uses only the T1?1 value as a parameter to distinguish tumor from normal tissue, and the accuracy of this detection is highly reliable.

Abstract: A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method includes collecting a plurality of sets of spatially distributed, time-varying magnetic field signals of the heart of a subject, wherein the magnetic field signals exhibit features of at least a wave, identifying a time corresponding to a local maximum intensity of the magnetic field signals of the wave at each measurement position and plotting a temporal evolution of the local maximum intensity of the magnetic field signals during a time interval of the wave.

Abstract: The present invention provides a probe-type SQUID system to detect magnetic particles stored in the living organisms or magnetic-labeling indicators for immunoassays and tumor or other applications. The probe-type SQUID system comprises a probe union, a SQUID union and a connecting electrically conducting wires such as copper wires, wherein the probe union is coupled with a cooling module such as TE cooler module to avoid power heating so that the probe can approach to the living organism to detect magnetic particles with high-sensitivity.

Abstract: A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method may include constructing a phase diagram of electromagnetic signals over a heart by collecting sets of time-dependent magnetic signals, determining the zeroth and the first derivations of each set of the magnetic signals at a given time, and categorizing the zeroth and the first derivations of the magnetic signals in either of the four phases: (+, +), (?, ?), (+, ?), (?, +). The method may also include monitoring a wave propagation of the magnetic signals.

Abstract: The invention provides a high resolution proton nuclear magnetic reonance and imaging (NMR/MRI) in microtesla magnetic fields by using high critical temperature (high-Tc) superconducting quantum interference device (SQUID) magnetometer via a flux transformer. Both the SQUID and the input coupling coil are installed inside a superconducting vessel which shields environmental noise and set the SQUID in a stable operation condition. The present invention also offers the advantages of preserving the NMR signal even if the sample is far away from the SQUID detector.

Abstract: A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method may include constructing a phase diagram of electromagnetic signals over a heart by collecting sets of time-dependent magnetic signals, determining the zeroth and the first derivations of each set of the magnetic signals at a given time, and categorizing the zeroth and the first derivations of the magnetic signals in either of the four phases: (+, +), (?, ?), (+, ?), (?, +). The method may also include monitoring a wave propagation of the magnetic signals.

Abstract: A method for suppressing non-specific bindings between molecules includes providing magnetic particles dispersed in a liquid, wherein each of the magnetic particles has a magnetization. The magnetic particles are coated with coating molecules. Binding molecules mixed of first-type binding molecules and second-type binding molecules are applied to the liquid, wherein the coating molecules are specifically binding with the first-type binding molecules and non-specifically binding with the second-type binding molecules. An alternating current (ac) magnetic field is applied at an axis with a frequency level, wherein the frequency level causes suppression of the second-type binding molecules in binding with the coating molecules.

Abstract: The present invention is directed to methods for quantitatively measuring biomolecules by using magnetic nanoparticles. Through the use of the magnetic nanoparticles and the bioprobes coated to the magnetic nanoparticles, the biomolecules conjugated with the bioprobes result in the formation of particle clusters. By measuring the changes in magnetic properties resulting from the existence of the bio-targets, the amount of the bio-targets in a sample to be tested can be measured.

Abstract: A method to quantitatively measure an amount of bio-molecules in a sample includes providing a solution having magnetic nanoparticles; coating bioprobe molecules to surfaces of the magnetic nanoparticles in the solution; measuring a first alternating current (ac) magnetization of the solution at a mixture frequency (?f1+?f2), wherein ? or ? is independently an integer larger than zero; adding a sample containing the bio-molecules to be detected to the solution, so that the biomolecules in the sample conjugate with the bioprobe molecules coated on the nanoparticles; and measuring a second ac magnetization of the solution at the mixture frequency (?f1+?f2) after adding the sample and incubation, so as to obtain an ac magnetization reduction at the mixture frequency (?f1+?f2) between the first and the second magnetization to determine the amount of the bio-molecules.

Abstract: A method for measuring a concentration of nucleic acids is described. The method includes providing bioprobe molecules that include single-stranded nucleic acids, wherein the bioprobe molecules are conjugated with magnetic beads in a solution. A sample of single-stranded target nucleic acids is added to solution, where the single-stranded target nucleic acids hybridize with the single-stranded nucleic acids of the bioprobe molecules. A reduction of the ac (alternating current) magnetic susceptibility of the solution prior and after the addition of the sample to the solution is determined.

Abstract: A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method includes collecting a plurality of sets of spatially distributed, time-varying magnetic field signals of the heart of a subject, wherein the magnetic field signals exhibit features of at least a wave, identifying a time corresponding to a local maximum intensity of the magnetic field signals of the wave at each measurement position and plotting a temporal evolution of the local maximum intensity of the magnetic field signals during a time interval of the wave.

Abstract: A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method may include constructing a phase diagram of electromagnetic signals over a heart by collecting sets of time-dependent magnetic signals, determining the zeroth and the first derivations of each set of the magnetic signals at a given time, and categorizing the zeroth and the first derivations of the magnetic signals in either of the four phases: (+, +), (?, ?), (+, ?), (?, +). The method may also include monitoring a wave propagation of the magnetic signals.