Abstract: An artificial short interfering peptide for the phosphorylation substrate of DAPK1 and its potential pharmaceutical applications is provided. In the field of peptide drug development, the peptide can be used in preparation of drugs for prevention and treatment of ischemic stroke, as well as the drugs for the disease that based on the same mechanism, such as traumatic brain injury, spinal cord injury, neonatal hypoxic-ischemic encephalopathy, depression, autism and neurodegenerative diseases like multiple sclerosis. Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's disease.

Abstract: The invention relates to an anti-blocking seawater desalination device based on graphene filtering, comprising heating device, solar heat-collecting device, fresh water condensation heat-exchange device and thermal-expansion and cold-shrinkage control valve mechanism; the heating device can fully heat and distill seawater, the sprayed seawater is distilled by graphene heat-conduction layers to improve the distillation efficiency and avoiding blocking; the distilled water vapor enters into fresh water condensation heat-exchange device to exchange heat with seawater, increasing the seawater temperature, making full use of the heat in water vapor, and increasing water vapor condensation speed; the distilled concentrated seawater enters into the thermal-expansion and cold-shrinkage control valve mechanism, the flow of seawater entering into the heating device is controlled by the concentrated seawater temperature, when the temperature is too high, the flow of the seawater entering into the heating device increase

Abstract: The invention relates to an anti-blocking seawater desalination device based on graphene filtering, comprising heating device, solar heat-collecting device, fresh water condensation heat-exchange device and thermal-expansion and cold-shrinkage control valve mechanism; the heating device can fully heat and distill seawater, the sprayed seawater is distilled by graphene heat-conduction layers to improve the distillation efficiency and avoiding blocking; the distilled water vapor enters into fresh water condensation heat-exchange device to exchange heat with seawater, increasing the seawater temperature, making full use of the heat in water vapor, and increasing water vapor condensation speed; the distilled concentrated seawater enters into the thermal-expansion and cold-shrinkage control valve mechanism, the flow of seawater entering into the heating device is controlled by the concentrated seawater temperature, when the temperature is too high, the flow of the seawater entering into the heating device increase

Abstract: Disclosed is a railway hopper car comprising a car body (6), a top cover (1, 2), a bogie (24), a braking device (21), a coupler buffer device (22), and a bottom door (25, 28) and a bottom door opening and closing mechanism (23) mounted at a discharge port at the bottom of a chassis. The railway hopper car further comprises a longitudinal saddle (31) disposed in the center of the car body (6) in the length direction thereof and arranged along the longitudinal direction of the car body (6). By providing the longitudinal saddle (31), the sequential requirement to close the left bottom door (25) and the right bottom door (28) is eliminated, thereby simplifying the structure of the linkage bottom door opening and closing mechanism and reducing manufacture and maintenance costs thereof.

Abstract: The invention relates to the technical field of seawater desalination, in particular to a graphene structure based on enhancing heat transfer effect and improving seawater desalination efficiency, comprising a porous sheet and a single-layer graphene adhered to the porous sheet, wherein the pore diameter of the porous sheet is 0-2000 nm. The graphene structure of the invention has higher efficiency when it is used for seawater desalination by enhancing heat transfer effect and increasing the loading capacity of the graphene structure. The invention reduces the engineering cost and operating cost of seawater desalination.

Abstract: Disclosed is a railway hopper car comprising a car body (6), a top cover (1, 2), a bogie (24), a braking device (21), a coupler buffer device (22), and a bottom door (25, 28) and a bottom door opening and closing mechanism (23) mounted at a discharge port at the bottom of a chassis. The railway hopper car further comprises a longitudinal saddle (31) disposed in the center of the car body (6) in the length direction thereof and arranged along the longitudinal direction of the car body (6). By providing the longitudinal saddle (31), the sequential requirement to close the left bottom door (25) and the right bottom door (28) is eliminated, thereby simplifying the structure of the linkage bottom door opening and closing mechanism and reducing manufacture and maintenance costs thereof.

Abstract: The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.

Abstract: The present invention provides a two-stage stiffness type elastomer combined device, including at least one small-stiffness elastic element and a large-stiffness elastic element, wherein the small-stiffness elastic element is arranged in an elastomer pre-compression device and is serially arranged with the large-stiffness elastic element under the action of a pre-compression load F1. The device has combined stiffness being hard at first and then becoming soft and is used as an elastic axle box suspension device of a railway vehicle, effectively solving the contradiction that a linear snaking critical operation speed of the vehicle and curve passing performance of the vehicle cannot be compromised.

Abstract: The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.

Abstract: The present invention provides a variable stiffness positioning device for a railway vehicle bogie axle box. The variable stiffness positioning device includes a vertical elastomer arranged between the top face of an axle box bearing saddle and the bottom surface of a guide frame of a side fame, and a longitudinal elastomer arranged between the axle box bearing saddle and the front and back side faces of the guide frame of the side fame, the longitudinal elastomer is provided with at least one small-stiffness elastic element and a large-stiffness elastic element, and the small-stiffness elastic element is arranged in an elastomer pre-compression device and is serially arranged with the large-stiffness elastic element under the action of a pre-compression load F1.

Abstract: The present invention provides a variable stiffness positioning device for a railway vehicle bogie axle box. The variable stiffness positioning device includes a vertical elastomer arranged between the top face of an axle box bearing saddle and the bottom surface of a guide frame of a side fame, and a longitudinal elastomer arranged between the axle box bearing saddle and the front and back side faces of the guide frame of the side fame, the longitudinal elastomer is provided with at least one small-stiffness elastic element and a large-stiffness elastic element, and the small-stiffness elastic element is arranged in an elastomer pre-compression device and is serially arranged with the large-stiffness elastic element under the action of a pre-compression load F1.

Abstract: The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.

Abstract: The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.

Abstract: The present invention provides a two-stage stiffness type elastomer combined device, including at least one small-stiffness elastic element and a large-stiffness elastic element, wherein the small-stiffness elastic element is arranged in an elastomer pre-compression device and is serially arranged with the large-stiffness elastic element under the action of a pre-compression load F1. The device has combined stiffness being hard at first and then becoming soft and is used as an elastic axle box suspension device of a railway vehicle, effectively solving the contradiction that a linear snaking critical operation speed of the vehicle and curve passing performance of the vehicle cannot be compromised.

Abstract: The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.

Abstract: The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.

Abstract: The invention provides a method and apparatus, in a network device, for forking a calling request to a first registered called user address among a plurality of registered called user addresses. The method comprises: obtaining forking-related information, the forking-related information corresponding to the public user identity code and representing a forking order relationship between at least one calling number and the plurality of registered called user addresses; receiving the calling request from a calling user equipment; determining the first registered called user address among the plurality of registered called user addresses according to the number of the calling user equipment and the forking-related information corresponding to the public user identity code; and forking the calling request to the first registered called user address.

Abstract: A dynamically adjustable digital gyrator device for a telephone line interface (e.g., a DAA) utilizing extended feedback and a dynamically adjustable filter to achieve stable convergence in the control of DC line current on a telephone line a short period of time. The low pass filter of the digital gyrator includes at least two (2) different fast filter settings and at least two (2) different slow filter settings based on possible load terminations (e.g., PBX, TAS, etc.), which can be determined based on the dynamic detection of an oscillation on the line. For instance, in a disclosed example, a voice band modem system is allowed to go off-hook with a 1 Hz cutoff low pass filter, and then the output of the low pass filter is checked for an oscillation. If an oscillation is detected, then the poles and/or zeroes of the low pass filter cutoff are changed to a slower convergence rate cutoff frequency (e.g., to 0.1 Hz). As a result, the exemplary voice band modem will converge stably and quickly (e.g.

Abstract: A dynamically adjustable digital gyrator device for a telephone line interface (e.g., a DAA) utilizing extended feedback and a dynamically adjustable filter to achieve stable convergence in the control of DC line current on a telephone line a short period of time. The low pass filter of the digital gyrator includes at least two (2) different fast filter settings and at least two (2) different slow filter settings based on possible load terminations (e.g., PBX, TAS, etc.), which can be determined based on the dynamic detection of an oscillation on the line. For instance, in a disclosed example, a voice band modem system is allowed to go off-hook with a 1 Hz cutoff low pass filter, and then the output of the low pass filter is checked for an oscillation. If an oscillation is detected, then the poles and/or zeroes of the low pass filter cutoff are changed to a slower convergence rate cutoff frequency (e.g., to 0.1 Hz). As a result, the exemplary voice band modem will converge stably and quickly (e.g.