Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

Abstract: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.

Abstract: A system and method for determining inflection points in an image of an object includes obtaining the image of the object, performing binary image processing on a border of the image to obtain border points, selecting a predetermined number of the border points to fit a straight line, calculating a vertical distance between each selected border point and the straight line, and obtaining a total distance. The method further includes adding a new border point to the selected border points if the total distance is less than a predetermined value, so as to fit a new straight line and do a loop cycle, otherwise, regarding a last border point of the selected border points as an inflection point, and sequentially selecting the predetermined number of other border points to fit another new straight line.

Abstract: A pigment dispersing polymer comprising a backbone having one or more urea groups and having polymeric side chains extending therefrom. The dispersing polymer may be formed from the reaction of a compound having one or more carbodiimide groups with acid functional resins such as acid functional polyesters, acid functional acrylics, acid functional polyethers, and fatty acids.

Abstract: The application of glycyrrhizic acid and its breakdown product glycyrrhetinic acid for the treatment of inflammatory bowel disease is disclosed. Glycyrrhizic acid or glycyrrhetinic acid and glycyrrhizinate or glycyrrhetate can treat inflammatory bowel disease by inhibiting inflammatory reactions and antioxidation.

Abstract: A method and system for computing and displaying a roundness error of an object specifies different colors that respectively represents an error range of points. The method and system receives a point cloud of the object and fits a circle based on the point cloud. The method and system computes an error of each point in the point cloud by computing a distance between the each point and the circle, colorizes the points in the point cloud according to the errors and the specified colors, and generates and outputting a graphic roundness error analysis report.

Abstract: A system and method for positioning a portion of an object to be measured includes installing a digital camera adjacent to a charge coupled device (CCD) lens of an image measuring machine, setting positioning parameters corresponding to different positions of the digital camera on a Z-axis of a world coordinate system, receiving an image of the object captured by the digital camera, and selecting corresponding positioning parameters according to a position of the digital camera. The method further includes selecting a point of the portion of the object in the image, calculating coordinates of the selected point in a plane of the CCD lens, and controlling the CCD lens to move to the calculated coordinates so as to position the CCD lens on the portion of the object.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.

Abstract: A pigment dispersing polymer comprising a backbone having one or more urea groups and having polymeric side chains extending therefrom. The dispersing polymer may be formed from the reaction of a compound having one or more carbodiimide groups with acid functional resins such as acid functional polyesters, acid functional acrylics, acid functional polyethers, and fatty acids.

Abstract: The present invention provides for a resin system and coating composition suitable for direct application to metal substrates. The composition may include a phosphate functional polyester. The polyester may be an unsaturated polyester polyol. The coating composition may further include a suitable curing agent, such as an isocyanate or melamine. The composition can be applied through traditional application equipment onto a variety of metal substrates and cures to an acceptable surface for further processing, such as top coating with basecoat and clearcoat.

Abstract: The present invention provides for a metal coating composition that includes a resin system with at least one unsaturated polyester polyol and a curing agent such as an isocyanate or a melamine. The compositions are suitable as a primer and provide good adhesion and moisture resistance to metal substrates.

Abstract: N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.

Abstract: The present invention provides for a sealer/primer that is generally cured at low bake temperatures. The composition utilizes a resin system to provide both conductivity and adhesion of the coating onto plastic substrates. The present invention uses a polyester, such as one that includes unsaturated polyester, in combination with other resins, including an acrylic, crosslinking agent and conductive pigment to create a conductive primer that can be cured at low temperatures. The composition can be applied through traditional application equipment, seals the surface of the substrate to which it is applied, and cures to an acceptable surface for further processing, such as painting.

Abstract: N-Benzoyl arylsulfonamides having the formula are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.

Abstract: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.

Abstract: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.