Abstract: A computer-implemented method, computer program product and computer system are provided. A processor receives an indication of sensitive data in one or more files. A processor updates at least one bit in the virtual address space for the one or more files indicated to have sensitive data. A processor, in response to a program accessing the one or more files, evaluates a respective virtual address for the one or more files. A processor, in response to the at least one bit in the respective virtual address for the one or more files, marks intermediate data generated by the program as sensitive data.

Abstract: A system for strabismus assessment and a method of strabismus assessment. The system comprises a display module arranged to display a visual stimulus to be observed by an observer; an image capturing module arranged to record a plurality of images of at least one eye of the observer observing the visual stimulus; and a processing module arranged to determine an ocular misalignment condition of the observer based on the plurality of images recorded by the image capturing module.

Abstract: Embodiments of the present disclosure relate to a method, system, and computer program product for dynamic update of a computer program in memory. According to the method, one or more processors obtain incremental information, the incremental information specifying an incremental update to at least one section of at least one target function in a computer program. One or more processors identify, based on the incremental information, the at least one target function to be updated from the computer program. One or more processors generate at least one updated copy of the at least one target function by updating the at least one section of the at least one target function based on the incremental information. One or more processors update the computer program based on the at least one updated copy of the at least one target function while the computer program is running.

Abstract: Provided herein are antibody-drug conjugates, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

Abstract: Embodiments of this application include an image processing method and apparatus, a non-transitory computer-readable storage medium, and an electronic device. In the image processing method a to-be-predicted medical image is input into a multi-task deep convolutional neural network model. The multi-task deep convolutional neural network model includes an image input layer, a shared layer, and n parallel task output layers. One or more lesion property prediction results of the to-be-predicted medical image is output through one or more of the n task output layers. The multi-task deep convolutional neural network model is trained with n types of medical image training sets, n being a positive integer that is greater than or equal to 2.

Abstract: A method implemented in an ophthalmic surgical laser system that employs a resonant scanner, scan line rotator, and XY- and Z-scanners, for forming a corneal flap in a patient's eye with improved bubble management during each step of the flap creation process. A pocket cut is formed first below bed level, followed by the bed connected to the pocket cut, then by a side cut extending from the bed to the anterior corneal surface. The pocket cut includes a pocket region located below the bed level and a ramp region connecting the pocket region to the bed. The bed is formed by a hinge cut and a first ring cut at lower laser energies, followed by a bed cut and then a second ring cut, which ensures that any location in the flap bed is cut twice to minimize tissue adhesion. The side cut is formed by multiple side-cut layers at different depths which are joined together. All cuts are formed by scanning a laser scan line generated by the resonant scanner.

Abstract: An ophthalmic surgical laser system includes a laser beam delivery system having multiple moving components for scanning a laser focal spot in a target eye tissue, where the motors that actuate some of the moving components are equipped with respective digital encoders that measure actual motor positions. A controller controls the laser beam delivery system to perform a treatment scan, while recording the actual motor positions from the encoders. Using the actual motor positions and a calibration relationship between actual motor positions and delivered laser focal spot positions in a target tissue, a laser cutting pattern is digitally reconstructed, which represents the incisions actually achieved by the treatment scan. The reconstructed laser cutting pattern may be visually inspected and further analyzed, e.g. to compare it to the intended laser cutting pattern used to execute the treatment scan, to calculate the achieved refractive correction, or to simulate tissue resetting.

Abstract: A method and apparatus for performing ophthalmic laser surgery using a pulsed laser beam is provided. The method includes establishing an initial cutting pattern comprising a plurality of original photodisruption points, establishing an enhanced cutting pattern comprising a plurality of enhanced photodisruption points selected to decrease potential adverse effects due to patient movement and having increased density over a fixed area as compared with the plurality of original photodisruption points, and performing an ocular surgical procedure according to the enhanced cutting pattern Enhanced cutting patterns may include circular cuts around the periphery of a capsule, vertical side cuts for lens fragmentation, raster lamellar cuts, and grid lamellar cuts. Each photodisruption point in the initial cutting pattern and the enhanced cutting pattern comprises a laser target point.

Abstract: An automatic spraying unmanned aerial vehicle (UAV) system based on dynamic adjustment of early warning range and a method thereof are disclosed. In the automatic spraying UAV system, an unmanned aerial vehicle analyzes a forward direction and a forward speed of a staff appearing in an environment video, calculates a preset distance, and generates an early-warning range by extending outwardly a spraying range by a preset distance; when determining the staff appears within the early-warning range in the environment video, the unmanned aerial vehicle pauses an automatic spraying operation, so as to achieve the technical effect of improving safety of the staff in an operation area by dynamically adjusting the early-warning range of the automatic spraying operation of the unmanned aerial vehicle.

Abstract: A measurement apparatus for measuring a laser focus spot size, which includes a two-dimensional image detector and an imaging system which forms a magnified image of a focus spot located an object plane onto the image detector. The imaging system includes at least an objective lens. A sealed liquid container is secured over a part of the objective lens such as the optical surface of the objective lens is immersed in the liquid (e.g. water) within the container. The liquid container has a window through which the laser beam enters. An image processing method is also disclosed which processes the image obtained by the image detector to obtain the focus spot size while implementing an algorithm that corrects for the effect of ambient vibration.

Abstract: A method, computer system, and a computer program for monitoring synchronization and aggregation are provided. The method may include receiving a plurality of metrics and identifying a plurality of metadata associated with the plurality of metrics. The method may further include calculating a hash value of the plurality of metadata based on the plurality of metrics. The method may further include detecting at least one modification to the plurality of metadata based on the hash value and updating the plurality of metrics based on the at least one modification in which the plurality of metrics are displayed in a self-adapting metric diagram.

Abstract: Aspects of the invention include includes detecting a change in a code section of a source code in relation to a reference code section. An incremental section is created in object code, the incremental section includes an object code section describing the change in the code section and a symbol section describing a change to a symbol associated with the changed code section. The incremental section is attached to a software update. The software update to a target computer system.

Abstract: Embodiments of the present disclosure relate to a method, system, and computer program product for dynamic update of a computer program in memory. According to the method, one or more processors obtain incremental information, the incremental information specifying an incremental update to at least one section of at least one target function in a computer program. One or more processors identify, based on the incremental information, the at least one target function to be updated from the computer program. One or more processors generate at least one updated copy of the at least one target function by updating the at least one section of the at least one target function based on the incremental information. One or more processors update the computer program based on the at least one updated copy of the at least one target function while the computer program is running.

Abstract: An ophthalmic laser system uses a non-confocal configuration to determine a laser beam focus position relative to the patient interface (PI) surface. The system includes a light intensity detector with no confocal lens or pinhole between the detector and the objective lens. When the objective focuses the light to a target focus point inside the PI lens at a particular offset from its distal surface, the light signal at the detector peaks. The offset value is determined by fixed system parameters, and can also be empirically determined by directly measuring the PI lens surface by observing the effect of plasma formation at the glass surface. During ophthalmic procedures, the laser focus is first scanned insider the PI lens, and the target focus point location is determined from the peak of the detector signal. The known offset value is then added to obtain the location of the PI lens surface.

Abstract: An ophthalmic laser system and related method for forming a lenticular incision in a corneal lenticule extraction procedure. The lenticular incision is formed by multiple sweeps of a laser scan line along meridians of longitude of the lenticular incision, where the end point of each sweep is connected to the start point of the next sweep by a smooth turning trajectory. The trajectory includes a first circular arc tangentially connected to the first sweep at its end point, a second circular arc tangentially connected to the next sweep at its start point, and a straight line segment tangentially connected to both circular arcs. The smooth trajectory is determined with the given limits of velocity, acceleration and jerk of the XY scanning motors, without using high frequency filters to smooth the trajectory, thereby avoiding unknown changes to the original trajectory and achieving high precision lenticule shapes.

Abstract: Systems and methods for adjusting an angle of incidence of a laser surgery system include a laser source to produce a laser beam and an optical delivery system to output the laser beam pulses to an object at an adjustable incident angle. A first rotator assembly receives the beam from the laser source along a first beam axis. The first rotator assembly rotates around the first beam axis and the first rotator assembly outputs the beam along a second beam axis different from the first beam axis. A second rotator assembly receives the beam from the first rotator assembly along the second beam axis. The second rotator assembly rotates around the second beam axis. The second rotator assembly follows the rotation of the first rotator assembly and the first rotator assembly is independent of the rotation of the second rotator assembly.

Abstract: A ophthalmic laser-assisted corneal lenticule extraction procedure that uses wavefront measurements to guide the formation of the corneal lenticule. The wavefront map measured from a free eye using a wavefront aberrometer is registered to the cornea of a docked eye based on comparisons of iris images and corneal markings. The docked-eye cornea-registered wavefront map is then corrected to be consistent with the Munnerlyn formula for the spherical power, and adjusted for any physician adjustments and/or myopia error due to a flat add in the lenticule, using Zernike polynomials. The corrected and adjusted wavefront map is then used to calculate the profiles of the bottom and top lenticule incisions in the applanated cornea, where higher-order components in the wavefront map are distributed to the bottom lenticule incision alone and lower-order components in the wavefront map are distributed to both the bottom and the top lenticule incision.

Abstract: Some embodiments disclosed here provide for a method fragmenting a cataractous lens of a patient's eye using an ultra-short pulsed laser. The method can include determining, within a lens of a patient's eye, a high NA zone where a cone angle of a laser beam with a high numerical aperture is not shadowed by the iris, and a low NA zone radially closer to the iris where the cone angle of the laser beam with a low numerical aperture is not shadowed by the iris. Laser lens fragmentation is accomplished by delivering the laser beam with the high numerical aperture to the high NA zone, and the laser beam with the low numerical aperture to the low NA zone. This can result in a more effective fragmentation of a nucleus of the lens without exposing the retina to radiation above safety standards.

Abstract: Embodiments of this invention generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for photorefractive keratectomy. In an embodiment, an ophthalmic surgical laser system comprises a laser source generating a pulsed laser beam and a laser delivery system delivering the pulsed laser beam to a cornea of an eye. A patient interface couples to and constrains the eye relative to the laser delivery system. A controller controls the laser delivery system to perform an anterior surface volume dissection on the cornea.