Abstract: The present invention relates to granules comprising Progerinin, capsules or sachets using same, and a preparation method therefor. More specifically, in order to develop a formulation that is advantageous when applying, to patients, Progerinin, which is a poorly water-soluble drug having a Hutchinson-Gilford progeria treatment effect, Progerinin granules comprising a specific water-soluble polymer, solubility enhancer and excipient at an optimum composition ratio have been developed and oral solid preparations such as capsules or sachets have been developed using the granules, such that dispersion stability and bioavailability of Progerinin can be improved and storage, transport and patient drug compliance can also be improved.