Abstract: Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a fibrotic cell.

Abstract: A valve (actuator) for performing pressurization, decompression and pressure maintenance drives plural spools movable up and down within a housing having plural bores by using linear shape memory alloys, and an anti-lock brake system utilizes the valve, in which respective bores have inlets and outlets, a mechanism for holding a lowering state of the spools is installed to the lower portion of the housing, and the spools return to their original positions by bias springs. A master cylinder, a wheel brake and a hydraulic pump are connected to the inlets and outlets of the valve of the anti-lock brake system and an electronic control unit is connected to the shape memory alloys to actuate the shape memory alloys, thereby attaining the operations of pressurization, decompression and pressure maintenance in connection with a brake pressure of the wheel brake.

Abstract: A simulator for testing an Anti-lock braking system modulator capable of easily setting the yawing of a vehicle and disproportionate concentration of a vehicle weight according to the various vehicle weights and diverse road surface conditions has wheels rotated by compressively contacting flywheel pairs, a flywheel driving portion for transmitting and managing a driving force to the flywheels, rotation-speed sensors for monitoring the rotational speed of the wheels and flywheels, pneumatic cylinders installed to respective wheels for regulating a frictional force between the wheels and flywheels, a braking system for inciting a braking force to the wheels to which a modulator to be tested is mounted, a pneumatic pressure generating circuit for supplying a predetermined pressure to the braking system and pneumatic cylinder, and a controller electrically connected to the flywheel driving portion, rotation-speed sensors and pneumatic pressure generating circuit, in which the controller controls the flywheel dri

Abstract: A valve for performing pressurization, decompression and pressure maintenance includes linear shape memory alloys. An anti-lock brake system utilizes the valve. The valve has plural spools movable up and down within a housing having plural bores. The respective bores have inlets and outlets. A mechanism for holding a lowering state of the spools is installed to the lower portion of the housing, and the spools return to their original positions by bias springs. In the anti-lock brake system, a master cylinder, wheel brakes and a hydraulic pump are connected to the inlets and outlets of the valve, and an electronic control unit is connected to the shape memory alloys to actuate the shape memory alloys, thereby attaining pressurization, decompression and maintenance of brake pressure.