Patents by Inventor HongJian Zhang

HongJian Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250230140
    Abstract: This application relates to novel triazole-pyridine substituted pyrrolidinyl, tetrahydro-2H-pyranyl, cyclohexyl, and piperidinyl acetic acid compounds, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with dysregulation of lysophosphatidic acid receptors (LPA).
    Type: Application
    Filed: April 28, 2022
    Publication date: July 17, 2025
    Applicant: Viva Star Biosciences (Suzhou) Co., Ltd.
    Inventors: Hongjian ZHANG, Ping CHEN, Zhenwei CAI, Fei JIANG, Peihua SUN
  • Patent number: 12338255
    Abstract: This application relates to novel bicyclic substituted sulfonylurea compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with modulation of cytokines such as IL-1? and IL-18, modulation of NLRP3, or inhibition of the activation of NLRP3 or related components of the inflammatory process.
    Type: Grant
    Filed: February 17, 2023
    Date of Patent: June 24, 2025
    Assignee: Viva Star Biosciences (Suzhou) Co., Ltd.
    Inventors: Ping Chen, Hongjian Zhang, Fei Jiang, Peihua Sun
  • Publication number: 20240400561
    Abstract: This application relates to novel substituted sulfonylurea compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with modulation of cytokines such as IL-1? and IL-18, modulation of NLRP3, or inhibition of the activation of NLRP3 or related components of the inflammatory process.
    Type: Application
    Filed: September 27, 2022
    Publication date: December 5, 2024
    Applicant: Viva Star Biosciences (Suzhou) Co., Ltd.
    Inventors: Hongjian ZHANG, Ping CHEN, Fei JIANG, Peihua SUN
  • Publication number: 20240369462
    Abstract: The present disclosure discloses an extremely high-temperature in-situ fretting fatigue experimental device for the mortise-tenon joint. The device includes: a loading member configured to support a tenon specimen and a mortise specimen, and apply a fatigue load; a heating member to heat the tenon specimen and the mortise specimen; a thermal insulation sleeve wrapping the heating member; a thermal insulation shield with an observation hole; and a control member configured to control opening or closing of the loading. Various measures including the using of heat-resistant materials for the gasket, thermal insulation shield and sleeve, reducing and shielding the thermal electrons, and decreasing the temperature in non-critical areas are adopted to improve the high-temperature imaging quality of the in-situ Scanning Electron Microscope (in-situ SEM) and enhance an upper limit of the in-situ SEM experimental temperature.
    Type: Application
    Filed: July 14, 2024
    Publication date: November 7, 2024
    Inventors: Qinan HAN, Jianwen FANG, Haitao CUI, Yue SU, Hongjian ZHANG, Huiji SHI
  • Publication number: 20240109887
    Abstract: This application relates to novel substituted bicyclic aza-heterocycles and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with mammalian RAS (Rat sarcoma virus) family proteins.
    Type: Application
    Filed: March 1, 2022
    Publication date: April 4, 2024
    Applicant: Viva Star Biosciences (Suzhou) Co., Ltd.
    Inventors: Hongjian ZHANG, Jingjing JI, Peihua SUN
  • Publication number: 20240109891
    Abstract: This application relates to novel heterotricyclic compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with mammalian RAS (Rat sarcoma virus) family proteins.
    Type: Application
    Filed: March 1, 2022
    Publication date: April 4, 2024
    Applicant: Viva Star Biosciences (Suzhou) Co., Ltd.
    Inventors: Hongjian ZHANG, Jingjing JI, Peihua SUN
  • Publication number: 20230279026
    Abstract: This application relates to novel bicyclic substituted sulfonylurea compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with modulation of cytokines such as IL-1? and IL-18, modulation of NLRP3, or inhibition of the activation of NLRP3 or related components of the inflammatory process.
    Type: Application
    Filed: February 17, 2023
    Publication date: September 7, 2023
    Inventors: Ping Chen, Hongjian Zhang, Fei Jiang, Peihua Sun
  • Patent number: 10669309
    Abstract: The present invention provides a method for extracting ?-polylysine (?-PL) and its hydrochloride salt from fermentation broth, which belongs to the field of bio-separation engineering. ?-PL and its hydrochloride salt are produced from fermentation broth through sequential solid-liquid separation, ultrafiltration, two-stage ion exchange, nanofiltration, evaporation concentration and drying techniques. Technologies of membrane filtration and two-stage ion exchange are applied to the preparation of ?-PL and its hydrochloride salt in the present invention, and the invention are characterized by reduced cost, improved automation, and increased product yield and purity, and the method of the present invention would be more suitable for industrial production.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: June 2, 2020
    Assignee: Jiangnan University
    Inventors: Xusheng Chen, Zhonggui Mao, Jianhua Zhang, Hongjian Zhang, Ke Wang, Honggang He
  • Publication number: 20180127462
    Abstract: The present invention provides a method for extracting ?-polylysine (?-PL) and its hydrochloride salt from fermentation broth, which belongs to the field of bio-separation engineering. ?-PL and its hydrochloride salt are produced from fermentation broth through sequential solid-liquid separation, ultrafiltration, two-stage ion exchange, nanofiltration, evaporation concentration and drying techniques. Technologies of membrane filtration and two-stage ion exchange are applied to the preparation of ?-PL and its hydrochloride salt in the present invention, and the invention are characterized by reduced cost, improved automation, and increased product yield and purity, and the method of the present invention would be more suitable for industrial production.
    Type: Application
    Filed: August 15, 2017
    Publication date: May 10, 2018
    Inventors: Xusheng Chen, Zhonggui Mao, Jianhua Zhang, Hongjian Zhang, Ke Wang, Honggang He
  • Patent number: 9896684
    Abstract: The present invention provides a device for nucleic acid extraction using a magnetic bead method. The device includes a disc turntable, an arc arch bridge base, a supporting column, and a magnet structural unit and a sample reaction unit both arranged on the disc turntable. The disc turntable includes a top plate; the arc arch bridge base includes a bottom plate arranged at the lowermost portion and an arc supporting plate arranged on the bottom plate, and the arc supporting plate corresponds to the guide rod insertion holes in position in a radial direction of the disc, and the arc supporting plate includes raised regions used for jacking up a guide rod and a magnet and groove regions used for allowing the guide rod and the magnet to fall. The device provided by the present invention can realize the automatic nucleic acid extraction in a stream-lining manner.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: February 20, 2018
    Inventors: Hongjian Zhang, Llzhong Dai
  • Publication number: 20170275614
    Abstract: The present invention provides a device for nucleic acid extraction using a magnetic bead method. The device includes a disc turntable, an arc arch bridge base, a supporting column, and a magnet structural unit and a sample reaction unit both arranged on the disc turntable. The disc turntable includes a top plate; the arc arch bridge base includes a bottom plate arranged at the lowermost portion and an arc supporting plate arranged on the bottom plate, and the arc supporting plate corresponds to the guide rod insertion holes in position in a radial direction of the disc, and the arc supporting plate includes raised regions used for jacking up a guide rod and a magnet and groove regions used for allowing the guide rod and the magnet to fall. The device provided by the present invention can realize the automatic nucleic acid extraction in a stream-lining manner.
    Type: Application
    Filed: June 14, 2017
    Publication date: September 28, 2017
    Inventors: Hongjian ZHANG, LIzhong DAI
  • Patent number: D921324
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: June 1, 2021
    Assignee: QINGDAO WORKERCARE TOOLS MANUFACTURE CO., LTD
    Inventor: Hongjian Zhang
  • Patent number: D923280
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: June 22, 2021
    Assignee: QINGDAO WORKERCARE TOOLS MANUFACTURE CO., LTD
    Inventor: Hongjian Zhang
  • Patent number: D1003800
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: November 7, 2023
    Assignee: Qingdao workercare tools manufacture co., ltd
    Inventor: Hongjian Zhang
  • Patent number: D1008151
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: December 19, 2023
    Assignee: Qingdao workercare tools manufacture co., ltd
    Inventor: Hongjian Zhang
  • Patent number: D1010541
    Type: Grant
    Filed: November 24, 2021
    Date of Patent: January 9, 2024
    Assignee: Qingdao Giant Industry & Trading Co., Ltd.
    Inventor: Hongjian Zhang
  • Patent number: D1038570
    Type: Grant
    Filed: April 3, 2023
    Date of Patent: August 6, 2024
    Assignee: Ouleme Technology (Qingdao) Co., Ltd.
    Inventor: Hongjian Zhang
  • Patent number: D1045771
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: October 8, 2024
    Assignee: Qingdao workercare tools manufacture co., ltd
    Inventor: Hongjian Zhang
  • Patent number: D1058989
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: January 21, 2025
    Assignee: Qingdao Giant Industry & Trading Co., Ltd
    Inventor: Hongjian Zhang
  • Patent number: D1065753
    Type: Grant
    Filed: April 3, 2023
    Date of Patent: March 4, 2025
    Assignee: Qingdao Workercare Tools Manufacture Co., Ltd
    Inventor: Hongjian Zhang