Abstract: This application relates to novel substituted sulfonylurea compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with modulation of cytokines such as IL-1? and IL-18, modulation of NLRP3, or inhibition of the activation of NLRP3 or related components of the inflammatory process.

Abstract: The present disclosure discloses an extremely high-temperature in-situ fretting fatigue experimental device for the mortise-tenon joint. The device includes: a loading member configured to support a tenon specimen and a mortise specimen, and apply a fatigue load; a heating member to heat the tenon specimen and the mortise specimen; a thermal insulation sleeve wrapping the heating member; a thermal insulation shield with an observation hole; and a control member configured to control opening or closing of the loading. Various measures including the using of heat-resistant materials for the gasket, thermal insulation shield and sleeve, reducing and shielding the thermal electrons, and decreasing the temperature in non-critical areas are adopted to improve the high-temperature imaging quality of the in-situ Scanning Electron Microscope (in-situ SEM) and enhance an upper limit of the in-situ SEM experimental temperature.

Abstract: This application relates to novel substituted bicyclic aza-heterocycles and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with mammalian RAS (Rat sarcoma virus) family proteins.

Abstract: This application relates to novel heterotricyclic compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with mammalian RAS (Rat sarcoma virus) family proteins.

Abstract: This application relates to novel bicyclic substituted sulfonylurea compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with modulation of cytokines such as IL-1? and IL-18, modulation of NLRP3, or inhibition of the activation of NLRP3 or related components of the inflammatory process.

Abstract: The present invention provides a method for extracting ?-polylysine (?-PL) and its hydrochloride salt from fermentation broth, which belongs to the field of bio-separation engineering. ?-PL and its hydrochloride salt are produced from fermentation broth through sequential solid-liquid separation, ultrafiltration, two-stage ion exchange, nanofiltration, evaporation concentration and drying techniques. Technologies of membrane filtration and two-stage ion exchange are applied to the preparation of ?-PL and its hydrochloride salt in the present invention, and the invention are characterized by reduced cost, improved automation, and increased product yield and purity, and the method of the present invention would be more suitable for industrial production.

Abstract: The present invention provides a method for extracting ?-polylysine (?-PL) and its hydrochloride salt from fermentation broth, which belongs to the field of bio-separation engineering. ?-PL and its hydrochloride salt are produced from fermentation broth through sequential solid-liquid separation, ultrafiltration, two-stage ion exchange, nanofiltration, evaporation concentration and drying techniques. Technologies of membrane filtration and two-stage ion exchange are applied to the preparation of ?-PL and its hydrochloride salt in the present invention, and the invention are characterized by reduced cost, improved automation, and increased product yield and purity, and the method of the present invention would be more suitable for industrial production.

Abstract: The present invention provides a device for nucleic acid extraction using a magnetic bead method. The device includes a disc turntable, an arc arch bridge base, a supporting column, and a magnet structural unit and a sample reaction unit both arranged on the disc turntable. The disc turntable includes a top plate; the arc arch bridge base includes a bottom plate arranged at the lowermost portion and an arc supporting plate arranged on the bottom plate, and the arc supporting plate corresponds to the guide rod insertion holes in position in a radial direction of the disc, and the arc supporting plate includes raised regions used for jacking up a guide rod and a magnet and groove regions used for allowing the guide rod and the magnet to fall. The device provided by the present invention can realize the automatic nucleic acid extraction in a stream-lining manner.

Abstract: The present invention provides a device for nucleic acid extraction using a magnetic bead method. The device includes a disc turntable, an arc arch bridge base, a supporting column, and a magnet structural unit and a sample reaction unit both arranged on the disc turntable. The disc turntable includes a top plate; the arc arch bridge base includes a bottom plate arranged at the lowermost portion and an arc supporting plate arranged on the bottom plate, and the arc supporting plate corresponds to the guide rod insertion holes in position in a radial direction of the disc, and the arc supporting plate includes raised regions used for jacking up a guide rod and a magnet and groove regions used for allowing the guide rod and the magnet to fall. The device provided by the present invention can realize the automatic nucleic acid extraction in a stream-lining manner.

Abstract: A heating pump includes an electric motor, a pump housing fixed to the motor, an impeller driven by the motor, and a ring heater with an inner hole for heating fluid in the pump housing. The pump housing has a pump chamber and a pump inlet and a pump outlet which are in fluid communication with the pump chamber. The impeller is received in the pump housing and having an impeller inlet and a plurality of impeller outlets. The ring heater is disposed inside the pump chamber and between the pump inlet and the impeller. The impeller inlet is in fluid communication with the pump inlet via the inner hole.

Abstract: A coreless permanent motor has a stator and a rotor rotatably mounted to the stator. One of the stator or the rotor has at least one winding disc (28). The other one of the stator or the rotor has at least one surface charged magnet disc (33). The winding disc (28) or the magnet disc (33) is formed by two or more sector shaped units that are mounted to two or more support members (27) respectively. The winding disc (28) or the magnet disc (33) is formed by closing the support member (27) and the closed support members (27) form a cylindrical housing. Thus, the structure of the coreless motor is simplified.