Abstract: Provided herein are compositions, methods, and uses involving bispecific binding molecules that specifically bind to HER2, a receptor tyrosine kinase, and to CD3, a T cell receptor, and mediate T cell cytotoxicity for managing and treating disorders, such as cancer. Also provided herein are uses and methods for managing and treating HER2-related cancers.

Abstract: Disclosed are a power demand side speech interaction method and system. The method includes: obtaining original demand information, the original demand information including user's basic information, user demand information, and a user demand time; converting the original demand information into first information in text format; performing text statistical analysis based on an industry term on the first information in text format, to obtain second information; searching for corresponding user's actual information from a database according to the second information; outputting the user's actual information; searching for a corresponding forecasting model from the database, according to the second information and the user's basic information; calculating, according to a policy limit value of latest policy information in the database, a time for which the model corresponding to the user's basic information reaches the policy limit value; and transmitting an early warning message.

Abstract: A method of controlling an air blowing apparatus includes: determining whether there is precipitation through a rain sensor by a controller; determining whether the air blowing apparatus is in an automatic mode in a precipitation condition by the controller; determining a vehicle speed when the air blowing apparatus is in the automatic mode in the precipitation condition; and setting power and a spray angle of the air blowing apparatus by comparing a rainfall received from the rain sensor to a stored rainfall by the controller. Setting the power and the spray angle of the air blowing apparatus includes compensating the spray angle and a spray amount by measuring a flow speed and a flow angle of rainwater through the rain sensor by the controller.

Abstract: A device for distributing washer fluid, which includes a case including one or more discharge holes, a rail part located in the case, a pipe assembly moved along the rail part and configured to discharge a washer fluid to the one or more discharge holes, a motor assembly configured to apply a driving force to allow the pipe assembly to be moved along the rail part, a hose engaged with the pipe assembly and integrally moved with the pipe assembly along the rail part, and a controller configured to control the driving force of the motor assembly in response to a cleaning request such that the pipe assembly discharges the washer fluid to a selected discharge hole.

Abstract: This invention discloses a pulse-sensing device and methods for pulse sensing. In one embodiment, the device includes a robotic finger comprising a humanoid-finger structure, and an actuating-force transferring member for transferring an actuating force to the structure at an actuation point thereon and along an actuation direction. One end of the structure is pivotally mounted to a fulcrum and another end has a sensing area. The robotic finger is configured such that, when the sensing area contacts a person's wrist, a first perpendicular distance from the fulcrum to a first line is substantially longer than a second perpendicular distance from the fulcrum to a second line, where the first line is a straight line passing through a sensing point of the sensing area and being substantially perpendicular to the sensing area, and the second line is a straight line passing through the actuation point and orienting along the actuation direction.

Abstract: A method for generating an EMF model includes establishing a time-domain finite data model associated with an electric device representing the electric device in the time-domain; utilizing the time domain finite data model, determining excitations representing an electrical characteristic of an electrical components of the electric device; and generating an EMF model by processing the excitations with a transformation routine determining an approximate representation of an EMF generated by the electric device. A system for generating the EMF model includes a modelling module establish a time-domain finite data model associated with the electric device and d representing the electric device in the time-domain. The modelling module utilizes the time domain finite data model to determine excitations representing an electrical characteristic of an electrical component of the electric device.

Abstract: A Raman signal detection and analyzing system and a method thereof are disclosed. The Raman signal is generated by emitting an excitation light to a sample. The Raman signal is then modulated by passing through a plurality of optical filter and modulator. The resulting modulated Raman signal comprises two orthogonal components, which intensities are to be computed based on the first harmonic of said modulated Raman signal. The content of a specific analyte within the sample can then be determined based on the ratio of the intensities of the two components.

Abstract: An electrical load driving apparatus comprising a thyristor circuit arranged to control a transmission of electric power to an electrical load, wherein the thyristor circuit is connected to a conversion module arranged to convert a characteristic of the thyristor circuit to operate with a load characteristic of the electrical load.

Abstract: An electrical load driving apparatus, comprising a current distribution apparatus having a power source arranged to deliver an input current into a plurality of branches such that the input current is distributed into a plurality of individual branch currents, wherein each of the plurality of branches includes an inductive arrangement arranged to form an inductive coupling with an associated inductive arrangement of at least one other associated branch, and a plurality of output loads connect to each of the associated branches of the current distribution apparatus.

Abstract: Devices and methods for preventing knee sprain injuries. To protect the knee joint from knee sprain injuries, the device comprises a sensing part configured to sense data associated with knee motion; an analyzing part configured to analyze the knee motion data to determine a knee articulation; and a stimulating part configured to stimulate one or more lower limb muscles to initiate an earlier muscle reaction than would naturally occur in response to the determined knee joint articulation. The determined knee joint articulation may include knee joint articulation or a particular type of articulation such as a knee sprain movement associated with knee sprain. The methods involve sensing data associated with knee joint motion, analyzing the data to determine a knee joint articulation; and stimulating one or more lower limb muscles to initiate an early muscle reaction within the determined knee joint articulation.

Abstract: A tracking device for an object comprising a body having at least one engagement member adapted to engage with the object, and a tracking arrangement chamber for housing a tracking arrangement arranged to track the object engaged with the body, wherein the tracking arrangement includes an antenna disposed adjacent to the body.

Abstract: The subject matter disclosed herein relates to an optical module that includes a mechanical structure to adjust a zoom level or focus of the optical module.

Abstract: A circuit and method for a bandgap voltage reference operating at 1 volt or below is disclosed, wherein the operational amplifier (A1) drives resistors (R2, R3) only so that both the flicker noise contribution and the process sensitivity due to the conventional metal oxide semiconductor (MOS) devices used as a current mirror within the proportional-to-absolute-temperature (PTAT) loop are eliminated. Two symmetric resistive divider pairs formed by (R1A/R1B, R2A/R2B) are inserted to scale down both the base-emitter voltages (VEB1, VEB2) of bipolar transistors (Q1, Q2) and the PTAT current (IPTAT) so that an output reference voltage (VREF) becomes scalable. Proper bias currents through transistors (M3, M4), which are used to bias (Q1, Q2) and (R1A/R1B, R2A/R2B) respectively, are produced by an additional V-I converter (319) using VREF itself, resulting in a final process, voltage and temperature (PVT) insensitive output reference voltage.

Abstract: Systems and methods in which antenna system configurations use over-coupling between a plurality of antenna elements for effectively providing wide-band operation are shown. Such over-coupling comprises a multiple antenna element configuration in which adaptation to one antenna element (e.g., an influencing antenna element) results in substantial operational frequency band adaptation to a second antenna element (e.g., a respondent antenna element). Over-coupling results in a frequency split at the second antenna, whereby the resonate frequency of the antenna element is split into a plurality of frequency bands. By implementing such frequency splitting with respect to otherwise narrow band antenna elements, the over-coupled antenna system may be made to effectively provide wide-band operation.

Abstract: A sine wave generator for a Direct Digital Synthesizer (DDS) converts a digital phase input into a digital sine wave output. Sine values and slopes are stored in read-only memory (ROM) for coarse upper phase bits in a first quadrant. A quadrant folder and phase splitter reflects and inverts values from the first quadrant to generate amplitudes for all four quadrants. Each sine value and slope is stored for a range of lower phase bits. A Delta bit separates upper and lower phase bits. Delta conditionally inverts the lower phase bits, the sine value, and the final polarity. A reduced AND logic array multiplies the slope by the conditionally inverted lower phase bits. A reconstructed ADD logic array then adds the conditionally inverted sine value. The conditionally inverted polarity is added to generate the final sine value. Sine generation logic is streamlined with conditional inversion based on the Delta bit.

Abstract: Disclosed herein are methods, systems, and apparatus for detecting microamplifications or microdeletions in the genome of a fetus. In some embodiments, the method comprises receiving sequence tags for each of a plurality of DNA fragments in a biological sample; determining genomic positions for the sequence tags; determining whether the density of DNA in each of a plurality of genomic regions is aberrantly high or low; identifying as a microamplification a set of consecutive genomic regions having aberrantly high density; and identifying as a microdeletion a set of consecutive genomic regions having aberrantly low density. The biological sample may be a blood sample obtained noninvasively from a female subject pregnant with the fetus.

Abstract: This invention provides a multi-stage amplifier incorporating DC offset cancellation. The amplifier has a plurality of series-connected gain stages each of which comprises a differential amplifier unit generating a pair of differential outputs from a pair of differential inputs. In particular, a trailing stage in the plurality of gain stages comprises a digital DC offset cancellation module configured to compensate for a DC offset of the trailing stage's differential amplifier unit. The digital DC offset cancellation module comprises a comparator coupled to the pair of differential outputs of the trailing stage's differential amplifier unit for receiving such differential outputs as inputs for the comparator. Preferably, the comparator has an inherent DC offset that is substantially small. It is preferable that a non-trailing stage of the amplifier comprises an analog DC offset cancellation module for compensating for a DC offset of the non-trailing stage.

Abstract: A low power, high accuracy calibration circuit for filter calibration is provided. The calibration circuit includes a chargeable voltage storage element. A first measurement and adjustment circuit determines a charge time required for the voltage of the chargeable voltage storage element to substantially match a reference voltage. The circuit adjusts the voltage storage element to make the charge time approximately equal to a predetermined filter time constant value, the adjustment circuit updating the reference voltage to make the charge time substantially equal to the predetermined filter time constant value and iteratively updating the reference voltage to refine the charge time. A second circuit is configured to have substantially the predetermined filter time constant value based on the adjustment configuration determined by the adjustment of the voltage storage element and the reference voltage of the first circuit.

Abstract: Systems and methods which provide generation of image depth maps which more accurately represent the local depth discontinuity within images through use of image global depth maps adapted based upon image global motion and/or localized depth analysis utilizing relative relationships of attributes across depth discontinuities in the image are disclosed. Embodiments utilize a full global depth map which is larger than or equal to the image being converted in order to accommodate image global motion, in generating an image global depth map. In operation according to embodiments, an image global depth map is identified within the full global depth map, such as based upon global motion within the image. Localized depth analysis, using pixel attribute relative relationships, is applied with respect to the image global depth map according to embodiments to generate an image depth map which more accurately reflects the local depth discontinuities within the image.

Abstract: This invention, which relates to retrieving an object from a video or a photo where the object matches a hand-drawn sketch, discloses a method for automatically estimating a perceptual bias level with respect to a feature of the sketch. The method allows estimation based on the sketch alone without involving an extra database. In one embodiment, the method comprises using an expectation-maximization tensor voting (EMTV) method to analyze a statistical distribution of the feature. The statistical distribution is analyzed by forming an objective function having the statistical distribution's information parameterized by the perceptual bias level, and then maximizing the objective function according to a set of iterative update rules. In another embodiment, the method for automatically estimating a perceptual bias level is incorporated into a method for retrieving one or more objects from an image or video database where the one or more objects match a hand-drawn sketch.