Patents by Inventor Hong-Kyu Lee

Hong-Kyu Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240341299
    Abstract: The present invention relates to a preservation solution composition for the preservation of an isolated cell, tissue, or organ, comprising isolated mitochondria; and a method for preserving an isolated cell, tissue, or organ by using the same. The preservation solution composition according to the present invention has excellent long-term preservability while maintaining the activity of isolated cell, tissue, or organ. Therefore, the present invention may be effectively used in the transplantation medicine field for ultimately improving transplant success rates and in the regenerative medicine field and the like.
    Type: Application
    Filed: July 22, 2022
    Publication date: October 17, 2024
    Inventors: Young-Cheol KANG, Kyuboem HAN, Chun-Hyung KIM, Hong Kyu LEE, Soomin KIM, Hendra TANOTO, Yin Hua ZHANG, Zhi Jun LIN, Hui Xing CUI
  • Patent number: 11244307
    Abstract: A transaction processing system may include: a plurality of leaf chains including a first leaf chain and a second leaf chain, the first leaf chain and the second leaf chain including a first leaf chain manager contract and a second leaf chain manager contract, respectively; a root chain comprising a root chain manager contract for the root chain, a first leaf chain contract for the first leaf chain, and a second leaf chain contract for the second leaf chain; and at least one relayer located between the root chain and the plurality of leaf chains, and configured to process a remittance request from the first leaf chain to the second leaf chain.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: February 8, 2022
    Assignee: LINE Plus Corporation
    Inventors: Hongsup So, Hong Kyu Lee, Jeehong Lee, Chul-soon Choi, Eunho Chang, Hojin Jang
  • Publication number: 20200210998
    Abstract: A transaction processing system may include: a plurality of leaf chains including a first leaf chain and a second leaf chain, the first leaf chain and the second leaf chain including a first leaf chain manager contract and a second leaf chain manager contract, respectively; a root chain comprising a root chain manager contract for the root chain, a first leaf chain contract for the first leaf chain, and a second leaf chain contract for the second leaf chain; and at least one relayer located between the root chain and the plurality of leaf chains, and configured to process a remittance request from the first leaf chain to the second leaf chain.
    Type: Application
    Filed: November 4, 2019
    Publication date: July 2, 2020
    Applicant: LINE Plus Corporation
    Inventors: Hongsup SO, Hong Kyu LEE, Jeehong LEE, Chul-soon CHOI, Eunho CHANG, HoJin JANG
  • Patent number: 10697027
    Abstract: A biological detection method for dioxin compounds in serum and its diagnostic use in predicting metabolic syndrome and related conditions are disclosed. The method of detecting dioxin compounds include obtaining a serum sample by heat-inactivating total serum obtained from a subject, preparing a transformed cell line by introducing a recombinant vector comprising a gene construct in which at least one dioxin-responsive element is operably linked to a promoter and a reporter gene into a host cell, culturing the transformed cell line with the serum sample, detecting the activation of the reporter gene in the transformed cell line, and determining that the dioxin compound is included in the serum sample when the activation of the reporter gene is detected. The serum detected by the method can be used as a surrogate serum biomarker to correlate serum content with disease factors and to predict the occurrence of disease and determine treatability.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: June 30, 2020
    Assignees: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
    Inventors: Hong Kyu Lee, Youngmi Kim
  • Publication number: 20190309376
    Abstract: A biological detection method for dioxin compounds in serum and its diagnostic use in predicting metabolic syndrome and related conditions are disclosed. The method of detecting dioxin compounds include obtaining a serum sample by heat-inactivating total serum obtained from a subject, preparing a transformed cell line by introducing a recombinant vector comprising a gene construct in which at least one dioxin-responsive element is operably linked to a promoter and a reporter gene into a host cell, culturing the transformed cell line with the serum sample, detecting the activation of the reporter gene in the transformed cell line, and determining that the dioxin compound is included in the serum sample when the activation of the reporter gene is detected. The serum detected by the method can be used as a surrogate serum biomarker to correlate serum content with disease factors and to predict the occurrence of disease and determine treatability.
    Type: Application
    Filed: May 20, 2019
    Publication date: October 10, 2019
    Inventors: Hong Kyu Lee, Youngmi Kim
  • Patent number: 10066215
    Abstract: Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: September 4, 2018
    Assignee: MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE
    Inventors: Kyuhyun Lee, Seongtae Yun, Daekyung Koh, Hong-Kyu Lee, Eui-Cheol Jo
  • Publication number: 20170107584
    Abstract: The present invention relates to a novel biological detection method for dioxins in serum and a diagnostic use thereof in metabolic syndrome and related conditions. More particularly, according to the present invention, a significant correlation between dioxin content in serum and physical variables has been confirmed by measuring luciferase activity through the use of serum as a whole and cells transformed with a recombinant vector comprising a gene construct in which a dioxin responsive element, a promoter and a reporter gene are operably linked. And there is an improvement in this method of the present invention over the conventional methods which require a preprocessing step in order to purify dioxins from serum, by which plural samples can be analyzed easily and accurately even with a very small amount of each because of the use of serum as a whole.
    Type: Application
    Filed: February 23, 2016
    Publication date: April 20, 2017
    Inventors: Hong Kyu Lee, Youngmi Kim
  • Publication number: 20170051256
    Abstract: Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.
    Type: Application
    Filed: September 28, 2016
    Publication date: February 23, 2017
    Applicant: MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE
    Inventors: Kyuhyun LEE, Seongtae YUN, Daekyung KOH, Hong-Kyu LEE, Eui-Cheol JO
  • Patent number: 9493745
    Abstract: Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: November 15, 2016
    Assignee: MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE
    Inventors: Kyuhyun Lee, Seongtae Yun, Daekyung Koh, Hong-Kyu Lee, Eui-Cheol Jo
  • Patent number: 9018182
    Abstract: Provided are tumor-specific promoters, oncolytic virus vectors and a pharmaceutical composition comprising the virus vector. The virus vector comprising the novel tumor-specific promoter shows excellent oncolytic effects on tumor cells, and thus it is useful for treating a cancer.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: April 28, 2015
    Assignees: Green Cross Corporation, Mogam Biotechnology Research Institute, Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Daekyung Koh, Seongtae Yun, Kyuhyun Lee, Hong-Kyu Lee, Mihee Hwang, Chae-Ok Yun, Eui-Cheol Jo
  • Publication number: 20150111282
    Abstract: Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.
    Type: Application
    Filed: October 23, 2014
    Publication date: April 23, 2015
    Applicant: MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE
    Inventors: Kyuhyun LEE, Seongtae YUN, Daekyung KOH, Hong-Kyu LEE, Eui-Cheol JO
  • Publication number: 20130171655
    Abstract: The present invention relates to a novel biological detection method for dioxins in serum and a diagnostic use thereof in metabolic syndrome and related conditions. More particularly, according to the present invention, a significant correlation between dioxin content in serum and physical variables has been confirmed by measuring luciferase activity through the use of serum as a whole and cells transformed with a recombinant vector comprising a gene construct in which a dioxin responsive element, a promoter and a reporter gene are operably linked. And there is an improvement in this method of the present invention over the conventional methods which require a preprocessing step in order to purify dioxins from serum, by which plural samples can be analyzed easily and accurately even with a very small amount of each because of the use of serum as a whole.
    Type: Application
    Filed: September 6, 2011
    Publication date: July 4, 2013
    Applicant: University-Industry Cooperation Group of Kyung Hee University
    Inventors: Hong Kyu Lee, Youngmi Kim
  • Publication number: 20130065952
    Abstract: Provided are tumor-specific promoters, oncolytic virus vectors and a pharmaceutical composition comprising the virus vector. The virus vector comprising the novel tumor-specific promoter shows excellent oncolytic effects on tumor cells, and thus it is useful for treating a cancer.
    Type: Application
    Filed: April 26, 2010
    Publication date: March 14, 2013
    Applicants: MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE, GREEN CROSS CORPORATION
    Inventors: Daekyung Koh, Seongtae Yun, Kyuhyun Lee, Hong-Kyu Lee, Mihee Hwang, Chae-Ok Yun, Eui-Cheol Jo
  • Publication number: 20130058897
    Abstract: Novel hexon isolated from simian adenovirus serotype 19 encoded in the polynucleotide defined as SEQ ID NO: 3, hepervariable region thereof, chimeric adenovirus comprising the same, and therapeutic use thereof provides a solution to the problem of safety and effective systemic treatment for developing gene therapeutic agents using adenovirus.
    Type: Application
    Filed: April 14, 2010
    Publication date: March 7, 2013
    Applicant: MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE
    Inventors: Kyuhyun Lee, Seongtae Yun, Daekyung Koh, Hong-Kyu Lee, Eui-Cheol Jo
  • Publication number: 20130041579
    Abstract: Disclosed is a method for sensing a traveling state based on a speed. The method for sensing the traveling state based on the speed includes outputting a mean speed C for each link with respect to a number of total traversing times of a predetermined path, and updating a reference speed B with the outputted mean speed C, and measuring a speed A while traversing the predetermined path, and comparing the measured speed A with the updated reference speed B, thereby displaying the traveling state.
    Type: Application
    Filed: August 22, 2012
    Publication date: February 14, 2013
    Applicant: Thinkware Systems Corporation
    Inventor: Hong Kyu Lee
  • Patent number: 8290694
    Abstract: Disclosed is a method for sensing a traveling state based on a speed. The method for sensing the traveling state based on the speed includes outputting a mean speed C for each link with respect to a number of total traversing times of a predetermined path, and updating a reference speed B with the outputted mean speed C, and measuring a speed A while traversing the predetermined path, and comparing the measured speed A with the updated reference speed B, thereby displaying the traveling state.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: October 16, 2012
    Assignee: Thinkware Systems Corporation
    Inventor: Hong Kyu Lee
  • Publication number: 20100049429
    Abstract: Disclosed is a method for sensing a traveling state based on a speed. The method for sensing the traveling state based on the speed includes outputting a mean speed C for each link with respect to a number of total traversing times of a predetermined path, and updating a reference speed B with the outputted mean speed C, and measuring a speed A while traversing the predetermined path, and comparing the measured speed A with the updated reference speed B, thereby displaying the traveling state.
    Type: Application
    Filed: December 10, 2007
    Publication date: February 25, 2010
    Inventor: Hong Kyu Lee
  • Patent number: 7636286
    Abstract: A front photo detector (FPD) of an optical pick-up for an optical recording and playing apparatus having no gain selection switch, a simplified configuration, an improved prevention of an abnormal operation due to an error in gain selection, and improved reliability. The front photo detector includes a photo diode unit, a current-voltage amplifying circuit, and a voltage amplifying unit. The photo diode unit outputs current proportional to the power of the light emitted from one of a plurality of laser diodes. The current-voltage amplifying circuit converts the current output from the photo diode unit into a voltage. The voltage amplifying circuit amplifies the voltage output from the current-voltage amplifying circuit by a predetermined gain.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: December 22, 2009
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Hong-kyu Lee, Hee-dong Kim, Pyong-yong Seong
  • Publication number: 20080208173
    Abstract: The present invention relates to an insulin pump having triple functions for the efficient regulation of a blood glucose concentration and an insulin injection system comprising the same. The insulin pump comprises an insulin syringe into which an insulin is stored, a pump to pressurize the insulin syringe in response to a programmed control signal, a control device that generates the programmed control signal to control the pump, a mode selection button to determine an insulin injection mode, and an operating button to command an insulin injection. The insulin injection mode is comprised of a base mode that continuously infuses the insulin at a basic rate to control a blood glucose concentration at a fasting, a food mode that infuses the insulin at a bulk to control the blood glucose concentration after food intake, and an activation mode that infuses the insulin in pulses for a predetermined time period.
    Type: Application
    Filed: November 4, 2005
    Publication date: August 28, 2008
    Inventors: Hong-Kyu Lee, Hee-Chan Kim
  • Patent number: 7417934
    Abstract: An optical pickup used to record information on and/or reproduce information from an optical recording medium, the optical pickup including an optical module to emit a light beam; and a front photo-detector to monitor power of the light beam; wherein the optical module is coupled to the front photo-detector so that a fixed distance is maintained between the optical module and the front photo-detector.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: August 26, 2008
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Young-pyo Lee, Cheol-sung Yeon, Hee-dong Kim, Hong-kyu Lee