Patents by Inventor Hongliang Zhao

Hongliang Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250059526
    Abstract: Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection.
    Type: Application
    Filed: June 18, 2024
    Publication date: February 20, 2025
    Inventors: Karl E. Griswold, Hongliang ZHAO
  • Patent number: 12104186
    Abstract: Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: October 1, 2024
    Assignee: INSMED INCORPORATED
    Inventors: Karl E. Griswold, Chris Bailey-Kellogg, Yoonjoo Choi, Kristina Blazanovic, Hongliang Zhao, Deeptak Verma
  • Patent number: 12049653
    Abstract: Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: July 30, 2024
    Assignee: Trustees of Dartmouth College
    Inventors: Karl E. Griswold, Hongliang Zhao
  • Publication number: 20240117903
    Abstract: An ultrahigh-pressure acid-fracturing isodiametric hose assembly, comprising a hose body and a metal joint. The metal joint comprises an inner tube, a first outer tube the inner tube, and a second outer tube. The first outer tube and the second outer tube each is an independent pressing part. An external groove is provided at an outer wall of the inner tube. An end of the first outer tube comprises an internal ridge which matches the external groove for snapping. The terminal of the inner tube comprises a connecting portion. An outer wall of the inner tube comprises a first protrusion, and an inner wall of the first outer tube comprises a second protrusion engaging with the first protrusion. The hose body is clamped between the first protrusion and the second protrusion that are engaged. An inner wall of the second outer tube comprises multiple micro-protrusions.
    Type: Application
    Filed: July 27, 2023
    Publication date: April 11, 2024
    Applicant: LUOHE LETONE HYDRAULICS TECHNOLOGY CO., LTD.
    Inventors: Hongliang ZHAO, Zhian LIU, Peiyuan WU, Feilong ZHANG, Xingpeng YANG, Lili LU, Yong ZHANG, Yanhui ZHAO, Pengfei ZHANG, Ning LI
  • Publication number: 20220213460
    Abstract: Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection.
    Type: Application
    Filed: September 21, 2021
    Publication date: July 7, 2022
    Inventors: Karl E. Griswold, Hongliang Zhao
  • Patent number: 11379687
    Abstract: Disclosed are a method for extracting a feature string, a device, a network apparatus, and a storage medium. The method comprises: determining, for each candidate feature string, a transition probability for each pair of adjacent characters in the candidate feature string according to a first-order Markov transition probability matrix; detennining a transition entropy value of the candidate feature string according to the transition probability of each pair of adjacent characters and the logarithm of the transition probability; and labeling a candidate feature string having a transition entropy value greater than a pre-determined threshold as a first usable feature string, and using a valid first usable feature string as an extracted target feature string.
    Type: Grant
    Filed: December 24, 2018
    Date of Patent: July 5, 2022
    Assignees: NSFOCUS TECHNOLOGIES GROUP CO., LTD., NSFOCUS TECHNOLOGIES, INC.
    Inventors: Dongjing He, Hongliang Zhao, Jiaxi Ren
  • Publication number: 20210395713
    Abstract: Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.
    Type: Application
    Filed: March 12, 2021
    Publication date: December 23, 2021
    Inventors: Karl E. GRISWOLD, Chris BAILEY-KELLOGG, Yoonjoo CHOI, Kristina BLAZANOVIC, Hongliang ZHAO, Deeptak Verma
  • Patent number: 11155801
    Abstract: Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: October 26, 2021
    Assignee: Trustees of Dartmouth College
    Inventors: Karl E. Griswold, Hongliang Zhao
  • Patent number: 11091749
    Abstract: Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: August 17, 2021
    Assignees: TRUSTEES OF DARTMOUTH COLLEGE, STEALTH BIOLOGICS, LLC
    Inventors: Karl E. Griswold, Chris Bailey-Kellogg, Yoonjoo Choi, Kristina Blazanovic, Hongliang Zhao, Deeptak Verma
  • Publication number: 20200349388
    Abstract: Disclosed are a method for extracting a feature string, a device, a network apparatus, and a storage medium. The method comprises: determining, for each candidate feature string, a transition probability for each pair of adjacent characters in the candidate feature string according to a first-order Markov transition probability matrix; determining a transition entropy value of the candidate feature string according to the transition probability of each pair of adjacent characters and the logarithm of the transition probability; and labeling a candidate feature string having a transition entropy value greater than a pre-determined threshold as a first usable feature string, and using a valid first usable feature string as an extracted target feature string.
    Type: Application
    Filed: December 24, 2018
    Publication date: November 5, 2020
    Inventors: Dongjing HE, Hongliang ZHAO, Jiaxi REN
  • Publication number: 20200040321
    Abstract: Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.
    Type: Application
    Filed: June 5, 2019
    Publication date: February 6, 2020
    Inventors: Karl E. GRISWOLD, Chris BAILEY-KELLOGG, Yoonjoo CHOI, Kristina BLAZANOVIC, Hongliang ZHAO, Deeptak Verma
  • Patent number: 10358636
    Abstract: Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: July 23, 2019
    Assignees: STEALTH BIOLOGICS, LLC, TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Karl E. Griswold, Chris Bailey-Kellogg, Yoonjoo Choi, Kristina Blazanovic, Hongliang Zhao, Deeptak Verma
  • Patent number: 9705757
    Abstract: Embodiments of the present invention disclose a method and terminal, an input method and device, a cloud service card, and a system for acquiring a service and relate to the field of cloud computing technologies. A method for acquiring cloud service content according to an embodiment of the present invention includes: acquiring, by a cloud terminal, an identifier of a service card; acquiring, by the cloud terminal, a cloud service instruction set corresponding to the identifier of the cloud service card from a cloud instruction set server according to the identifier of the cloud service card; and acquiring, by the cloud terminal, cloud service content from a cloud service server according to a cloud service instruction in the cloud service instruction set. The present invention is applicable to quick acquisition of a latest cloud service provided by an operator.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: July 11, 2017
    Assignee: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Jian Chen, Pinyang Zou, Hongliang Zhao, Fuhai Dong
  • Patent number: D960876
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: August 16, 2022
    Inventor: Hongliang Zhao
  • Patent number: D1027890
    Type: Grant
    Filed: December 14, 2022
    Date of Patent: May 21, 2024
    Inventors: Gang Deng, Hongliang Zhao
  • Patent number: D1027919
    Type: Grant
    Filed: November 11, 2022
    Date of Patent: May 21, 2024
    Inventors: Hongliang Zhao, Jinshu Hu
  • Patent number: D1047983
    Type: Grant
    Filed: February 7, 2023
    Date of Patent: October 22, 2024
    Inventor: Hongliang Zhao
  • Patent number: D1056881
    Type: Grant
    Filed: February 7, 2023
    Date of Patent: January 7, 2025
    Assignee: Shenzhen Jiayz Photo Industrial., Ltd
    Inventor: Hongliang Zhao
  • Patent number: D1067903
    Type: Grant
    Filed: August 1, 2023
    Date of Patent: March 25, 2025
    Inventors: Hongliang Zhao, Jinshu Hu, Zhaoyang Xu, Shengqun Yu
  • Patent number: D1068743
    Type: Grant
    Filed: May 26, 2023
    Date of Patent: April 1, 2025
    Inventors: Hongliang Zhao, Xiaohua Lu, Zhaoyang Xu