Abstract: Provided herein are compounds, such as compounds of Formula (I), Formula (I-A), Formula (I-B), or pharmaceutically acceptable salts of any one there, useful for modulating KRAS GD12 and/or other G12 mutants.

Abstract: A sound receiving/broadcasting system according to the present invention includes a master device and a plurality of slave sound receiving/broadcasting devices. The master device wirelessly communicates with each slave sound receiving/broadcasting devices. Upon receiving a first audio input signal, the master device transmits a first transmission signal to each of the slave sound receiving/broadcasting devices, and all of the slave sound receiving/broadcasting devices separately output first output sounds according to the received first transmission signals.

Abstract: A backlight control circuit includes a power supply circuit, a local dimming circuit, a backlight driving circuit, and a supply voltage adjustment circuit. The power supply circuit is used to output the power supply voltage to a backlight module. The backlight module has multiple dimming zones, and each dimming zone has light emitting diodes (LEDs). The local dimming circuit is used to generate a local dimming signal according to image data and a configuration of the dimming zones. The backlight driving circuit is used to generate backlight driving signals to the dimming zones of the backlight module according to the local dimming signal. The supply voltage adjustment circuit is used to generate a first supply voltage adjustment signal to the power supply circuit for adjusting the power supply voltage based on the local dimming signal and a characteristic data of each LED in the dimming zones.

Abstract: A socket of a testing tool is configured to provide testing signals. A device-under-test (DUT) board is configured to provide electrical routing. An integrated circuit (IC) die is disposed between the socket and the DUT board. The testing signals are electrically routed to the IC die through the DUT board. The IC die includes a substrate in which plurality of transistors is formed. A first structure contains a plurality of first metallization components. A second structure contains a plurality of second metallization components. The first structure is disposed over a first side of the substrate. The second structure is disposed over a second side of the substrate opposite the first side. A trench extends through the DUT board and extends partially into the IC die from the second side. A signal detection tool is configured to detect electrical or optical signals generated by the IC die.

Abstract: A leather defect detection system comprises a worktable, a conveying mechanism, an image capture module, a model training computing device and an embedded computing device, the worktable is used to place a to-be-detected leather; the conveying mechanism is movably disposed on the worktable; the image capture module is disposed on the conveying mechanism, when the conveying mechanism is actuated, relative positions of the image capture module and the to-be-detected leather change synchronously to capture a plurality of to-be-detected images respectively; the model training computing device uses a plurality of historical leather images captured by the image capture module to perform calculation to establish a defect identification model, and the defect identification model is transcoded into the embedded computing device, so that the embedded computing device is capable of directly using the transcoded defect identification model to perform defect identification on the to-be-detected images.

Abstract: A package component includes a first substrate and a first conductive layer. The first substrate has a first surface and a second surface opposite to the first surface. The first conductive layer is disposed over the first surface of the first substrate. The first conductive layer includes a first conductive feature and a second conductive feature over the first conductive feature. The second conductive features covers a portion of the first conductive feature. A resistance of the second conductive feature is lower than a resistance of the second conductive feature. The first substrate includes a single-sided or a double-sided copper-clad laminate.

Abstract: A phase-change memory (PCM) cell is provided to include a first electrode, a second electrode, and a phase-change feature disposed between the first electrode and the second electrode. The phase-change feature is configured to change its data state based on a write operation performed on the PCM cell. The write operation includes a reset stage and a set stage. In the reset stage, a plurality of reset current pulses are applied to the PCM cell, and the reset current pulses have increasing current amplitudes. In the set stage, a plurality of set current pulses are applied to the PCM cell, and the set current pulses exhibit an increasing trend in current amplitude. The current amplitudes of the set current pulses are smaller than those of the reset current pulses.

Abstract: The present disclosure provides a method for selective removal of undifferentiated pluripotent stem cells including inducing stem cells differentiation, and then administering an effective amount of phthalide for the removal of undifferentiated pluripotent stem cells.

Abstract: A closed cell separation operation apparatus includes a first tube body having a vent and an inlet, a second tube body having a vent and an inlet and a connecting pipe, connecting the first tube body and a second tube body; the vent of the first tube body allows air to enter and exit the first tube body and the inlet of the first body allows a fluid from an external fluid source to enter the first tube body; and the first tube body having an outlet; the vent of the second tube body allows air to enter and exit the second tube body and the inlet of the second tube body allows at least one part of the fluid from the outlet of the first tube body to enter the second tube body and the second tube body having an outlet. The closed cell separation operation apparatus provides a closed, contamination-free environment for both centrifugation and post-centrifugation supernatant separation.

Abstract: Provided is a cell proliferation apparatus, comprising (a) a device for cell storage or cell culture; and (b) a means or a unit to deliver an airflow to the device for cell storage or the cell culture. Also provide is an in vitro method to induce cell proliferation, by placing a plurality of cells in the cell proliferation apparatus described herein.

Abstract: The present disclosure provides herein monotherapies of a LILRB antagonist (e.g., an anti-LILRB2 antibody or anti-LILRB4 antibody) and combination therapies of the LILRB antagonist (e.g., an anti-LILRB2 antibody or anti-LILRB4 antibody) and a PD-1/PD-L1 axis inhibitor for cancer patients. Wherein the antagonist of LILRB is an anti-LILRB1 antibody, an anti-LILRB2 antibody, an anti-LILRB3 antibody, an anti-LILRB4 antibody, an anti-LILRB5 antibody or an anti-LAIR1 antibody.

Abstract: A visual vehicle-positioning fusion system and a method thereof is provided. In the method, an image point cloud map stored in a storage device is converted into a longitude and latitude database corresponding to the image point cloud map. Longitude and latitude measurement coordinates received by a positioning device are used as first location information. The longitude and latitude database is compared with the longitude and latitude measurement coordinates to generate the initial location of a vehicle. Feature matching is performed on the initial location and the image point cloud map to generate second location information of the vehicle on the image point cloud map. The first location information or the second location information is selected as a final positioning output information and outputted based on a positioning fusion rule.

Abstract: An integrated circuit (IC) chip assembly includes an integrated circuit (IC) die that includes a first substrate in which plurality of transistors is formed, a first structure that contains a plurality of first metallization components, and a second structure that contains a plurality of second metallization components. The first structure is disposed over a first side of the first substrate. The second structure is disposed over a second side of the first substrate opposite the first side. The chip assembly includes a second substrate bonded to the IC die through the second side. The chip assembly includes a trench that extends through the second substrate and through the second structure of the IC die. Sidewalls of the trench are defined at least in part by one or more protective layers.

Abstract: The invention relates to the synthesis of a carboxyl-functional, unsaturated polyurethane containing a perfluoropolyether block, which can be used as an easy clean additive in preparation of a waterborne, UV curable coating composition. The polyurethane can be prepared by a method comprising the following steps: a) subjecting a hydroxy-terminated perfluoropolyether A to a reaction with a molar excess of polyisocyanate B to obtain an isocyanate-functional urethane C, b) adding a carboxyl-functional polyol D to the reaction mixture, c) adding OH— functional (meth)acrylate monomer E to the reaction mixture, wherein steps (b) and (c) can be performed in any order, and d) neutralizing the reaction product with a neutralizer F. The resulting coating has easy clean and anti-stain properties.

Abstract: An integrated circuit (IC) with through-circuit vias (TCVs) and methods of forming the same are disclosed. The IC includes a semiconductor device, first and second interconnect structures disposed on first and second surfaces of the semiconductor device, respectively, first and second inter-layer dielectric (ILD) layers disposed on front and back surfaces of the substrate, respectively, and a TCV disposed within the first and second interconnect structures, the first and second ILD layers, and the substrate. The TCV is spaced apart from the semiconductor device by a portion of the substrate and portions of the first and second ILD layers. A first end of the TCV, disposed over the front surface of the substrate, is connected to a conductive line of the first interconnect structure and a second end of the TCV, disposed over the back surface of the substrate, is connected to a conductive line of the second interconnect structure.

Abstract: A heat dissipation module is adapted for being installed on a circuit board. The heat dissipation module includes a fixed base and a heat dissipating device. One end of the fixed base is adapted for being fixed to the circuit board, and the other end has a rotating component. The rotating component is pivoted on the fixed base along a rotation axis. The heat dissipation device includes a heat dissipation body and an alignment member extending from the heat dissipation body, and the alignment member is adapted to be detachably connected to the rotating component. When the heat dissipation device is connected to the rotating component through the alignment member, the heat dissipation body is adapted to flip relative to the fixed base along the rotating axis.

Abstract: A flow battery stack is provided with carbon-felt electrodes etched with canals. The stack comprises carbon-felt electrodes, bipolar plates, separating membranes, and electrolytes. A plurality of canals are etched on the surface of the electrode to increase the flow rate of electrolyte for improving reactivity. With the carbon-felt electrodes used in the flow battery stack, a long-term and stable charging/discharging operation is achieved with the cost of electricity storage effectively reduced.

Abstract: A method of providing merchant risk monitoring may include receiving structured data that is directly associated with transactional operations of a merchant, and is formatted for application to a risk rating module, receiving unstructured data that is directly associated with the transactional operations of the merchant, but which is not formatted for application to the risk rating module, receiving non-traditional data that is not directly associated with the transactional operations of the merchant and is not formatted for application to the risk rating module, filtering the non-traditional data for relevance to merchant risk to define filtered data, pre-treating the unstructured data to generate pre-treated data that is formatted for application to the risk rating module, and applying the filtered data, the pre-treated data and the structured data to the risk rating module to employ machine learning for generation of a risk rating for the merchant.

Abstract: A method of extracting and conditioning content for use in a hierarchically structured merchant risk monitoring environment may include receiving an indication of a merchant under consideration, identifying one or more web pages likely to have information associated with travel exposure for the merchant under consideration based on the indication, conducting data scraping on the identified one or more web pages to attempt to obtain scraped travel exposure data, responsive to obtaining the scraped travel exposure data, employing a machine learning module to determine a travel risk exposure estimate based on the scraped travel exposure data, and responsive to not obtaining the scraped travel exposure data, determining the risk exposure estimate based on a predefined travel risk estimate associated with an industry classification of the merchant under consideration.

Abstract: An apparatus, for use with a projectile launching device, includes the sight, including a viewfinder that permits a user to view an image of a target in association with a reticle, a digital image system for capturing images of the target, multiple sensors to detect a firing time the apparatus for capturing multiple first images at or close to said firing time, wherein an image processor compares images captured after said firing time with said multiple first images, and to identify an indication of a projectile impact on said target, the apparatus being configured to capture multiple second images after said firing time and including said projectile impact indication, and wherein the apparatus includes a reticle adjuster to automatically position the reticle in the viewfinder in accordance with comparison between first images and second images and the associated positions of the reticle and the projectile impact indication.