Abstract: An anti-ANGPTL3 antibody or an antigen-binding fragment thereof. The present invention provides an anti-ANGPTL3 antibody or an antigen-binding fragment thereof, wherein a heavy chain variable region includes complementarity determining regions (CDRs), including CDR-H1 having an amino acid sequence as set forth in SEQ ID No. 1, CDR-H2 having an amino acid sequence as set forth in SEQ ID No. 2, and CDR-H3 having an amino acid sequence as set forth in SEQ ID No. 3; and the CDRs of a light chain variable region includes CDR-L1 having an amino acid sequence as set forth in SEQ ID No. 4, CDR-L2 having an amino acid sequence as set forth in SEQ ID No. 5, and CDR-L3 having an amino acid sequence as set forth in SEQ ID No. 6. The antibody or the antigen-binding fragment thereof provided in the present invention can specifically recognize ANGPTL3.

Abstract: A cutting tool includes: a drive device for driving a saw blade to rotate; a base plate having an upper surface and a lower surface, wherein the lower surface is configured to abut against a cut material; a body accommodating at least part of the drive device and connected to the upper surface; a handle at least partially configured behind the body; and a junction portion for detachably mounting a battery set. When a cutting depth of the cutting tool is changed and a cutting angle of the cutting tool remains unchanged, a position of the handle relative to the base plate remains unchanged. The cutting tool is comfortable and convenient to use.

Abstract: A method and a kit for determining genome instability based on next generation sequencing (NGS) are disclosed. The new method is used to determine whether there is homologous recombination defect by calculating a comprehensive value of one or more of pathogenic germline and somatic mutations, such as SNV, indels, and CNVs, and Biallelic germline and somatic mutations, pathogenic mutational signature, copy number variation (CNV) in homologous recombination repair (HRR) gene, genomic structural variation and genome instability. The genomics DNA is interrupted and added with an A adapter; then corresponding polymerase chain reaction (PCR) is conducted, and Whole genome sequencing is performed; the hybrid capture is conducted with designed probes of HRR genes and SNPs, and a captured DNA library is subjected to amplification and library sequencing; and then professional bioinformatics software is used for evaluation to determine the homologous recombination deficiency (HRD) status.

Abstract: Disclosed herein are methods, systems, and apparatus, including computer programs encoded on computer storage media, for detecting and disabling replay attacks. One of the methods includes receiving a transaction to be completed in a blockchain. A current working section of memory storing transaction information that is designated for use in identifying past transactions already processed is determined, where the memory also stores a backup section providing, when used in combination with the current working section, an alternating memory section storage scheme for the transaction information. From the current working section, whether the transaction has previously been processed is determined. When it is determined that the transaction has previously been processed, the transaction is bypassed. When it is determined that the transaction has not previously been processed the transaction is processed and transaction information for the transaction is written into the current working section.

Abstract: A device and a method for detecting tumor mutation burden (TMB) based on capture sequencing are disclosed. The device includes: a panel design module configured to uniformly add population single-nucleotide polymorphism (SNP) sites to a genome and screen out gene regions that show the highest consistency with whole exome sequencing (WES); a data acquisition module configured to acquire tissue and plasma samples of a target object and acquire sequencing data of the samples; an alignment module configured to align the sequencing data with a reference genome to acquire mutation data results; a somatic mutation analysis module configured to perform somatic analysis on the mutation data results to obtain somatic mutation results; a filtering module configured to remove unreal mutation sites from the somatic mutation results; and a calculation module configured to calculate the TMB.

Abstract: A method and a kit for determining genome instability based on next generation sequencing (NGS) are disclosed. The new method is used to determine whether there is homologous recombination defect by calculating a comprehensive value of one or more of pathogenic germline and somatic mutations, such as SNV, indels, and CNVs, and Biallelic germline and somatic mutations, pathogenic mutational signature, copy number variation (CNV) in homologous recombination repair (HRR) gene, genomic structural variation and genome instability. The genomics DNA is interrupted and added with an A adapter; then corresponding polymerase chain reaction (PCR) is conducted, and Whole genome sequencing is performed; the hybrid capture is conducted with designed probes of HRR genes and SNPs, and a captured DNA library is subjected to amplification and library sequencing; and then professional bioinformatics software is used for evaluation to determine the homologous recombination deficiency (HRD) status.

Abstract: Disclosed herein are methods, systems, and apparatus, including computer programs encoded on computer storage media, for detecting and disabling replay attacks. One of the methods includes receiving a transaction to be completed in a blockchain. A current working section of memory storing transaction information that is designated for use in identifying past transactions already processed is determined, where the memory also stores a backup section providing, when used in combination with the current working section, an alternating memory section storage scheme for the transaction information. From the current working section, whether the transaction has previously been processed is determined. When it is determined that the transaction has previously been processed, the transaction is bypassed. When it is determined that the transaction has not previously been processed the transaction is processed and transaction information for the transaction is written into the current working section.

Abstract: Disclosed herein are methods, systems, and apparatus, including computer programs encoded on computer storage media, for detecting and disabling replay attacks. One of the methods includes receiving a transaction to be completed in a blockchain. A current working section of memory storing transaction information that is designated for use in identifying past transactions already processed is determined, where the memory also stores a backup section providing, when used in combination with the current working section, an alternating memory section storage scheme for the transaction information. From the current working section, whether the transaction has previously been processed is determined. When it is determined that the transaction has previously been processed, the transaction is bypassed. When it is determined that the transaction has not previously been processed the transaction is processed and transaction information for the transaction is written into the current working section.

Abstract: Disclosed herein are methods, systems, and apparatus, including computer programs encoded on computer storage media, for detecting and disabling replay attacks. One of the methods includes receiving a transaction to be completed in a blockchain. A current working section of memory storing transaction information that is designated for use in identifying past transactions already processed is determined, where the memory also stores a backup section providing, when used in combination with the current working section, an alternating memory section storage scheme for the transaction information. From the current working section, whether the transaction has previously been processed is determined. When it is determined that the transaction has previously been processed, the transaction is bypassed. When it is determined that the transaction has not previously been processed the transaction is processed and transaction information for the transaction is written into the current working section.

Abstract: Disclosed herein are methods, systems, and apparatus, including computer programs encoded on computer storage media, for detecting and disabling replay attacks. One of the methods includes receiving a transaction to be completed in a blockchain. A current working section of memory storing transaction information that is designated for use in identifying past transactions already processed is determined, where the memory also stores a backup section providing, when used in combination with the current working section, an alternating memory section storage scheme for the transaction information. From the current working section, whether the transaction has previously been processed is determined. When it is determined that the transaction has previously been processed, the transaction is bypassed. When it is determined that the transaction has not previously been processed the transaction is processed and transaction information for the transaction is written into the current working section.

Abstract: Disclosed herein are methods, systems, and apparatus, including computer programs encoded on computer storage media, for detecting and disabling replay attacks. One of the methods includes receiving a transaction to be completed in a blockchain. A current working section of memory storing transaction information that is designated for use in identifying past transactions already processed is determined, where the memory also stores a backup section providing, when used in combination with the current working section, an alternating memory section storage scheme for the transaction information. From the current working section, whether the transaction has previously been processed is determined. When it is determined that the transaction has previously been processed, the transaction is bypassed. When it is determined that the transaction has not previously been processed the transaction is processed and transaction information for the transaction is written into the current working section.

Abstract: Disclosed herein are methods, systems, and apparatus, including computer programs encoded on computer storage media, for enhancing blockchain network security. Embodiments of this specification include receiving a transaction request from a client, wherein the transaction request includes a transaction requested to be recorded on a blockchain and a transaction hash calculated based on hashing the transaction; determining the transaction hash is not previously stored in a cache resource or the blockchain; storing the transaction hash in the cache resource; and executing the transaction request.

Abstract: The document applies to the field of information processing, and provides a method and device for acquiring product information, and a computer storage medium. The method includes that: original comment information of a user relevant to a product is collected from a public platform; the collected original information is filtered; the filtered information is analyzed and information on relevance to the product is acquired; and information on user feedback on the product is acquired by classifying and then counting and analyzing the acquired information on relevance. With what is described here, a problem in acquiring, by related art, information on user feedback on a product, such as high cost, low efficiency, platform bias, and failure to acquire quantitative data for high accuracy and the like, may be solved effectively.

Abstract: A method for a network device to access a packet switched network is applied to a system in which the network device accesses the packet switched network by connecting to PEs in an active-standby mode. The method includes: an active PE and a standby PE each sends a fault detection message to the network device through an interface connected to the network device; the active PE sets the state of the interface to “up” and advertises a route to a remote PE if a fault detection response returned by the network device is received through the interface within a preset period; otherwise, the active PE sets the state of the interface to “down” , and withdraws the advertised route; and the standby PE sets the state of the interface to “up” and advertises another route to the remote PE after receiving a fault detection response through the interface connected to the network device.

Abstract: A method and a system for sampling a packet as well as a device are disclosed herein. The method includes the following steps: a notification node of an LSP sends obtained information about the protocol type of a packet to a specific netflow sampling entity; the netflow sampling entity determines the protocol type of the packet according to the information about the protocol type after receiving the packet, and samples the packet according to the determined protocol type. Through the embodiments of the present invention, the accuracy of netflow sampling is improved significantly.

Abstract: A method, a system, and an apparatus for implementing a layer-2 virtual private network (L2VPN) between autonomous systems (ASs) are disclosed. The method includes: receiving a first L2VPN mapping packet from a first AS; parsing the first L2VPN mapping packet to obtain a first label carried in the first L2VPN mapping packet, applying for a second label which is different from the first label carried in the first L2VPN mapping packet, and generating a second L2VPN mapping packet according to the second label; and sending the second L2VPN mapping packet to a second AS. When multiple VPN users need to establish a multi-protocol label switching (MPLS) L2VPN between ASs, the MPLS L2VPN can be established between ASs through the technical solution under the present invention as long as a link exists between the ASs, thus providing high extensibility, high security, and convenient management of the inter-AS L2VPN.

Abstract: A method for a network device to access a packet switched network is applied to a system in which the network device accesses the packet switched network by connecting to PEs in an active-standby mode. The method includes: an active PE and a standby PE each sends a fault detection message to the network device through an interface connected to the network device; the active PE sets the state of the interface “up” and advertises a route to a remote PE if a fault detection response returned by the network device is received through the interface within a preset period; otherwise, the active PE sets the state of the interface to “down” , and withdraws the advertised route; and the standby PE sets the state of the interface to “up” and advertises another route to the remote PE after receiving a fault detection response through the interface connected to the network device.

Abstract: A method for a network device to access a packet switched network is applied to a system in which the network device accesses the packet switched network by connecting to PEs in an active-standby mode. The method includes: an active PE and a standby PE each sends a fault detection message to the network device through an interface connected to the network device; the active PE sets the state of the interface to “up” and advertises a route to a remote PE if a fault detection response returned by the network device is received through the interface within a preset period; otherwise, the active PE sets the state of the interface to “down”, and withdraws the advertised route; and the standby PE sets the state of the interface to “up” and advertises another route to the remote PE after receiving a fault detection response through the interface connected to the network device.

Abstract: A method, a system, and an apparatus for implementing a layer-2 virtual private network (L2VPN) between autonomous systems (ASs) are disclosed. The method includes: receiving a first L2VPN mapping packet from a first AS; parsing the first L2VPN mapping packet to obtain a first label carried in the first L2VPN mapping packet, applying for a second label which is different from the first label carried in the first L2VPN mapping packet, and generating a second L2VPN mapping packet according to the second label; and sending the second L2VPN mapping packet to a second AS. When multiple VPN users need to establish a multi-protocol label switching (MPLS) L2VPN between ASs, the MPLS L2VPN can be established between ASs through the technical solution under the present invention as long as a link exists between the ASs, thus providing high extensibility, high security, and convenient management of the inter-AS L2VPN.

Abstract: A method for acquiring a virtual private network (VPN) label is provided, in which the VPN is based on a multi-protocol label switching (MPLS) network. The method includes: acquiring VPN routing information; parsing the VPN routing information to obtain a VPN identifier, an upper-level router device identifier, and a receiving label; and acquiring a forwarding label according to the VPN identifier, the upper-level router device identifier, and the receiving label. The method is applied to an autonomous system boundary router (ASBR) device.