Abstract: A method for manufacturing core-shell metal nanoparticles is provided. The method comprises providing a first solution containing a metal ion; providing a second solution containing Arabinogalactan and having a pH value ranging from about 1 to about 13; mixing the first solution and the second solution to form a third solution; and enabling the third solution to perform an oxidation-reduction reaction to form the core-shell metal nanoparticles. The core-shell metal nanoparticles comprise a core composed of metal; and a shell, composed of Arabinogalactan, covering the surface of he core.

Abstract: The present invention provides novel ophthalmic drug delivery formulation which comprises a mixture of Carbopol and Pluronic. Carbopol is a trademark of B.F. Goodrich Company's high molecular weight carboxy vinyl polymers (MW above 1,000,000). Pluronic belongs to a class of block copolymers containing polyoxyethylene and polyoxypropylene. The preferred weight percentages of Carbopol and Pluronic in the ophthalmic drug delivery formulation are 0.3% of Carbopol and 14% of Pluronic. The ocular bioavailability is greatly enhanced by the use of the ophthalmic drug delivery formulation of the present invention.