Patents by Inventor Hong-Sen Chen
Hong-Sen Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11773167Abstract: The present disclosure provides antibodies, including antibody fusions, which specifically bind to human PD-L1 protein (huPD-L1) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by PD-L1, such as binding to the immune checkpoint molecule PD-1 in the tumor microenvironment. Additionally, the antibodies include fusions with the cytokine inhibitory factor, IL10, which can replenish and/or activate CD8+ T-cell cytotoxicity in the tumor microenvironment. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by PD1 binding to PD-L1.Type: GrantFiled: July 21, 2022Date of Patent: October 3, 2023Assignee: ELIXIRON IMMUNOTHERAPEUTICS (HONG KONG) LIMITEDInventors: Hung-Kai Chen, Hong-Sen Chen, Huey-Wen Hsiao
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Publication number: 20230078173Abstract: The present disclosure provides antibodies, including antibody fusions, which specifically bind to human PD-L1 protein (huPD-L1) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by PD-L1, such as binding to the immune checkpoint molecule PD-1 in the tumor microenvironment. Additionally, the antibodies include fusions with the cytokine inhibitory factor, IL10, which can replenish and/or activate CD8+ T-cell cytotoxicity in the tumor microenvironment. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by PD1 binding to PD-L1.Type: ApplicationFiled: July 21, 2022Publication date: March 16, 2023Applicant: ELIXIRON IMMUNOTHERAPEUTICS (HONG KONG) LIMITEDInventors: Hung-Kai CHEN, Hong-Sen CHEN, Huey-Wen HSIAO
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Patent number: 11434277Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.Type: GrantFiled: October 19, 2018Date of Patent: September 6, 2022Assignee: ACADEMIA SINICAInventors: An-Suei Yang, Ing-Chien Chen, Yi-Kai Chiu, Chung-Ming Yu, Cheng-Chung Lee, Chao-Ping Tung, Yueh-Liang Tsou, Yi-Jen Huang, Chia-Lung Lin, Hong-Sen Chen, Hwei-Jiung Wang
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Publication number: 20210070843Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.Type: ApplicationFiled: October 19, 2018Publication date: March 11, 2021Inventors: An-Suei YANG, Ing-Chien CHEN, Yi-Kai CHIU, Chung-Ming YU, Cheng-Chung LEE, Chao-Ping TUNG, Yueh-Liang TSOU, Yi-Jen HUANG, Chia-Lung LIN, Hong-Sen CHEN, Hwei-Jiung WANG
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Patent number: 10752673Abstract: Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.Type: GrantFiled: June 12, 2017Date of Patent: August 25, 2020Assignee: ACADEMIA SINICAInventors: An-Suei Yang, Hong-Sen Chen, Chung-Ming Yu, Shin-Chen Hou, Wei-Ying Kuo, Yi-Kai Chiu, Yueh-Liang Tsou, Hung-Ju Hsu, Hwei-Jiung Wang, Shih-Hsien Chuang, Chao-Pin Lee
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Patent number: 10562976Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.Type: GrantFiled: October 22, 2018Date of Patent: February 18, 2020Assignee: Academia SinicaInventors: An-Suei Yang, Wei-Ying Kuo, Hung-Ju Hsu, Hong-Sen Chen, Yu-Chi Chou, Yueh-Liang Tsou, Hung-Pin Peng, Jhih-Wei Jian, Chung-Ming Yu, Yi-Kai Chiu, Ing-Chein Chen, Chao-Ping Tung, Michael Hsiao, Hwei-Jiung Wang
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Patent number: 10472411Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: GrantFiled: May 13, 2019Date of Patent: November 12, 2019Assignee: Academia SinicaInventors: An-Suei Yang, Hong-Sen Chen, Ing-Chien Chen, Chao-Ping Tung, Shin-Chen Hou, Chung-Ming Yu, Chi-Kai Yang, Yi-Kai Chiu
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Patent number: 10415033Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized in having a specific CS combination and a specific sequence in each CDR. The present scFv library is useful in efficiently producing different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: GrantFiled: November 28, 2018Date of Patent: September 17, 2019Assignee: Academia SinicaInventors: An-Suei Yang, Jhih-Wei Jian, Hong-Sen Chen, Yi-Kai Chiu, Hung-Pin Peng, Chao-Ping Tung, Chung-Ming Yu, Wei-Ying Kuo, Hung-Ju Hsu
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Publication number: 20190263893Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: ApplicationFiled: May 13, 2019Publication date: August 29, 2019Applicant: Academia SinicaInventors: An-Suei YANG, Hong-Sen CHEN, Ing-Chien CHEN, Chao-Ping TUNG, Shin-Chen HOU, Chung-Ming YU, Chi-Kai YANG, Yi-Kai CHIU
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Patent number: 10336816Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: GrantFiled: February 23, 2016Date of Patent: July 2, 2019Assignee: Academia SinicaInventors: An-Suei Yang, Hong-Sen Chen, Ing-Chien Chen, Chao-Ping Tung, Shin-Chen Hou, Chung-Ming Yu, Chi-Kai Yang, Yi-Kai Chiu
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Publication number: 20190085323Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized in having a specific CS combination and a specific sequence in each CDR. The present scFv library is useful in efficiently producing different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: ApplicationFiled: November 28, 2018Publication date: March 21, 2019Applicant: Academia SinicaInventors: An-Suei Yang, Jhih-Wei Jian, Hong-Sen Chen, Yi-Kai Chiu, Hung-Pin Peng, Chao-Ping Tung, Chung-Ming Yu, Wei-Ying Kuo, Hung-Ju Hsu
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Publication number: 20190040151Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.Type: ApplicationFiled: October 22, 2018Publication date: February 7, 2019Applicant: Academia SinicaInventors: An-Suei YANG, Wei-Ying KUO, Hung-Ju HSU, Hong-Sen CHEN, Yu-Chi CHOU, Yueh-Liang TSOU, Hung-Pin PENG, Jhih-Wei JIAN, Chung-Ming YU, Yi-Kai CHIU, Ing-Chein CHEN, Chao-Ping TUNG, Michael HSIAO, Hwei-Jiung WANG
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Publication number: 20180009877Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: ApplicationFiled: February 23, 2016Publication date: January 11, 2018Applicant: Academia SinicaInventors: An-Suei YANG, Hong-Sen CHEN, Ing-Chien CHEN, Chao-Ping TUNG, Shin-Chen HOU, Chung-Ming YU, Chi-Kai YANG, Yi-Kai CHIU
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Publication number: 20170355750Abstract: Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.Type: ApplicationFiled: June 12, 2017Publication date: December 14, 2017Applicant: Academia SinicaInventors: An-Suei YANG, Hong-Sen CHEN, Chung-Ming YU, Shin-Chen HOU, Wei-Ying KUO, Yi-Kai CHIU, Yueh-Liang TSOU, Hung-Ju HSU, Hwei-Jiung WANG, Shih-Hsien CHUANG, Chao-Pin LEE
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Patent number: 7560114Abstract: The present invention provides methods of modulating an immune response in an organism by administering medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum.Type: GrantFiled: December 6, 2007Date of Patent: July 14, 2009Inventors: Yuan-Yuan Wang, Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey Wong, Chun-Hung Lin, Hong-Sen Chen, Yow-Fu Tsai
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Publication number: 20080267991Abstract: The present invention provides methods of modulating an immune response in an organism by administering medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum.Type: ApplicationFiled: December 6, 2007Publication date: October 30, 2008Inventors: Yuan-Yuan Wang, Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey Wong, Chun-Hung Lin, Hong-Sen Chen, Yow-Fu Tsai
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Patent number: 7323176Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.Type: GrantFiled: October 26, 2006Date of Patent: January 29, 2008Assignee: Academia SinicaInventors: Yuan-Yuan Wang, Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey Wong, Chun-Hung Lin, Hong-Sen Chen, Yow-Fu Tsai
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Publication number: 20070104729Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.Type: ApplicationFiled: October 26, 2006Publication date: May 10, 2007Applicant: ACADEMIA SINICAInventors: Yuan-Yuan Wang, Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey Wong, Chun-Hung Lin, Hong-Sen Chen, Yow-Fu Tsai
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Patent number: 7135183Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.Type: GrantFiled: August 6, 2002Date of Patent: November 14, 2006Assignee: Academia SinicaInventors: Yuan-Yuan Wang, Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey Wong, Chun-Hung Lin, Hong-Sen Chen, Yow-Fu Tsai