Patents by Inventor Hong Tian
Hong Tian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240142175Abstract: Disclosed are an unblocking apparatus for a furnace discharging pipe and a use method. The unblocking apparatus includes a rail, a rail car that may move along the rail, an unblocking drive mechanism arranged on the rail car, a heat-unblocking component, a cold-unblocking component, and a material receiving component that is used to receive a blocking material in the discharging pipe, and a drive end of the unblocking drive mechanism is detachably connected with one end of the heat-unblocking component and the cold-unblocking component respectively. The present application effectively handles different blockage situations of the furnace discharging pipe by connecting the unblocking drive mechanism with an unblocking rod capable of heat-unblocking and a drilling rod capable of cold-unblocking, thereby two modes of heat-unblocking and cold-unblocking are performed on the furnace discharging pipe; and the discharging pipe may be unblocked by a remote operation.Type: ApplicationFiled: October 23, 2023Publication date: May 2, 2024Applicants: China Nuclear Sichuan Environmental Protection Engineering Co., Ltd., China Building Materials Academy, China Nuclear Power Engineering Co., Ltd.Inventors: Weidong XU, Yu CHANG, Yongchang ZHU, Hong DUAN, Chunyu TIAN, Wei WU, Debo YANG, Qingbin ZHAO, Shuaizhen WU, Lin WANG, Zhu CUI, Heyi GUO, Maosong FAN, Yuancheng SUN, Jie MEI, Xiaoli AN, Yongxiang ZHAO, Qinda LIU
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Patent number: 11952401Abstract: The present disclosure belongs to the technical field of biological products for veterinary medicine, and specifically relates to a recombinant foot-and-mouth disease virus (FMDV) with a reduced immunosuppressive activity, a preparation method and use thereof, and a recombinant vaccine strain. According to the present disclosure, it is firstly discovered that FMDV 3B protein has an immunosuppressive function, and key sites for exerting the immunosuppressive function are found. A recombinant FMDV vaccine strain with a lost immunosuppressive function in FMDV 3B protein is constructed by introducing amino acid mutations into three repeated copies of FMDV 3B protein.Type: GrantFiled: July 14, 2021Date of Patent: April 9, 2024Assignee: Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural SciencesInventors: Haixue Zheng, Fan Yang, Zixiang Zhu, Xiangle Zhang, Weijun Cao, Congcong Wang, Kangli Li, Huisheng Liu, Hong Tian, Keshan Zhang, Xiangtao Liu
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Publication number: 20240111826Abstract: An apparatus to facilitate hardware enhancements for double precision systolic support is disclosed. The apparatus includes matrix acceleration hardware having double-precision (DP) matrix multiplication circuitry including a multiplier circuits to multiply pairs of input source operands in a DP floating-point format; adders to receive multiplier outputs from the multiplier circuits and accumulate the multiplier outputs in a high precision intermediate format; an accumulator circuit to accumulate adder outputs from the adders with at least one of a third global source operand on a first pass of the DP matrix multiplication circuitry or an intermediate result from the first pass on a second pass of the DP matrix multiplication circuitry, wherein the accumulator circuit to generate an accumulator output in the high precision intermediate format; and a down conversion and rounding circuit to down convert and round an output of the second pass as final result in the DP floating-point format.Type: ApplicationFiled: September 30, 2022Publication date: April 4, 2024Applicant: Intel CorporationInventors: Jiasheng Chen, Kevin Hurd, Changwon Rhee, Jorge Parra, Fangwen Fu, Theo Drane, William Zorn, Peter Caday, Gregory Henry, Guei-Yuan Lueh, Farzad Chehrazi, Amit Karande, Turbo Majumder, Xinmin Tian, Milind Girkar, Hong Jiang
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Patent number: 11949522Abstract: One aspect provides a power sourcing equipment controller for providing power to a powered device using power-over-Ethernet (PoE). The power sourcing equipment includes a voltage-output logic block to output a sequence of voltage signals, the voltage signals comprising at least a detection signal and a classification signal; a current-measurement logic block to measure current provided responsive to the voltage signals; a backoff-time-determination logic block to determine a backoff time in response to the current-measurement logic block detecting the provided current exceeding a predetermined threshold, the backoff time being determined based on an amount of time needed for discharging an internal capacitor associated with the powered device; and a timing logic block to cause the voltage-output logic block to delay the output of a next sequence of voltage signals based on the determined backoff time, thereby facilitating powering up of a device compliant with a different PoE standard.Type: GrantFiled: August 5, 2021Date of Patent: April 2, 2024Assignee: Hewlett Packard Enterprise Development LPInventors: Shiyu Tian, Kah Hoe Ng, Hong Yi Wee
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Patent number: 11891411Abstract: An industrialization method for comprehensive utilization of Stevia rebaudiana. The major improvement is in that the Stevia rebaudiana is extracted by using a high-concentration alcohol solution, then the extracted solution is purified by using an organic solvent, and the pH of the extracted solution is adjusted to be alkaline according to the acidic characteristic of chlorogenic acid to enable the chlorogenic acid to be formed into a salt and have an increased polarity so as to achieve effective separation of the chlorogenic acid and a glucoside component in an adsorption process. The method allows the high-quality stevioside and chlorogenic acid to be obtained, significantly improves the comprehensive utilization rate of Stevia rebaudiana, reduces the waste of natural Stevia rebaudiana resources, reduces the resource consumption in a production process, reduces waste discharge, and is a high-benefit green production process.Type: GrantFiled: March 30, 2021Date of Patent: February 6, 2024Assignee: Chenguang Biotech Group Co., Ltd.Inventors: Meili Xu, Yunhe Lian, Hong Tian, Wei Gao, Yachao Xu
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Patent number: 11883411Abstract: The present disclosure belongs to the technical field of African swine fever (ASF) treatment, in particular to use of a compound aprepitant in prevention or treatment of the ASF. In the present disclosure, it is found that the compound aprepitant can significantly inhibit replication of an African swine fever virus (ASFV); in addition, it is found that the aprepitant inhibits transcription and protein expression of D1133L, and reduces transcription and protein expression levels of p30 and p72, preventing virus invasion on host cells. Therefore, the compound aprepitant can be used to inhibit early and late infection of the ASFV. Accordingly, the compound aprepitant can be used to prevent or treat the ASF.Type: GrantFiled: August 25, 2022Date of Patent: January 30, 2024Assignee: LANZHOU VETERINARY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCESInventors: Keshan Zhang, Haixue Zheng, Huimei Cui, Bo Yang, Hong Tian, Zixiang Zhu, Tao Feng, Fan Yang, Weijun Cao, Xusheng Ma, Yi Ru, Jianhong Guo, Xiangtao Liu
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Patent number: 11883482Abstract: The disclosure provides a recombinant nucleic acid of Seneca valley virus, a recombinant vaccine strain and preparation method and use thereof, and relates to the technical field of genetic engineering. The disclosure provides the recombinant nucleic acid of Seneca valley virus, recombinant Seneca valley virus comprising the recombinant nucleic acid, recombinant Seneca valley virus encoded by the recombinant nucleic acid, recombinant Seneca valley virus vaccine strain comprising the recombinant Seneca valley virus and preparation method and use thereof. According to the disclosure, a vaccine strain characterized by high antigen production capacity, remarkably reduced pathogenicity (even having no pathogenicity to pigs), strong antibody induction activity, high immune protection rate is prepared. The vaccine strain remarkably improves the biological safety and can be used for preventing and controlling Seneca valley virus in China and the neighboring countries.Type: GrantFiled: May 24, 2021Date of Patent: January 30, 2024Inventors: Haixue Zheng, Fan Yang, Zixiang Zhu, Weijun Cao, Hong Tian, Keshan Zhang, Ting Wei, Min Zheng, Wei Zhang, Wen Dang, Xusheng Ma, Dan Li, Yi Ru, Jijun He, Jianhong Guo, Xiangtao Liu
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Publication number: 20230295641Abstract: The present disclosure belongs to the technical field of biology, and in particular relates to an attenuated strain of African swine fever virus (ASFV) with IPTG-induced deletion of a D1133L gene and use thereof. In the present disclosure, it is firstly found that the D1133L protein of ASFV can inhibit production of IFN-? and downstream cytokines ISG-15 and ISG-56, and can be used as an immunosuppressant with a relatively strong immunosuppressive effect. In addition, the attenuated strain of ASFV with IPTG-induced deletion of the D1133L gene is constructed. Specifically, a screening expression cassette is inserted into a position before the non-structural protein gene D1133L of the ASFV using an Escherichia coli lac operator-repressor system, to obtain a recombinant virus. In the presence of the IPTG, the recombinant virus has similar characteristics to a wild-type virus; and in the absence of the IPTG, the expression of the D1133L protein is inhibited.Type: ApplicationFiled: November 21, 2022Publication date: September 21, 2023Applicant: LANZHOU VETERINARY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCESInventors: Haixue ZHENG, Keshan ZHANG, Ting ZHANG, Tao FENG, Bo YANG, Xing YANG, Xijuan SHI, Hong TIAN, Yi RU, Fan YANG, Zixiang ZHU, Jianhong GUO, Jijun HE, Xiangtao LIU
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Publication number: 20230270747Abstract: The present disclosure belongs to the technical field of African swine fever (ASF) treatment, in particular to use of a compound aprepitant in prevention or treatment of the ASF. In the present disclosure, it is found that the compound aprepitant can significantly inhibit replication of an African swine fever virus (ASFV); in addition, it is found that the aprepitant inhibits transcription and protein expression of D1133L, and reduces transcription and protein expression levels of p30 and p72, preventing virus invasion on host cells. Therefore, the compound aprepitant can be used to inhibit early and late infection of the ASFV. Accordingly, the compound aprepitant can be used to prevent or treat the ASF.Type: ApplicationFiled: August 25, 2022Publication date: August 31, 2023Applicant: LANZHOU VETERINARY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCESInventors: Keshan ZHANG, Haixue ZHENG, Huimei CUI, Bo YANG, Hong TIAN, Zixiang ZHU, Tao FENG, Fan YANG, Weijun CAO, Xusheng MA, Yi RU, Jianhong GUO, Xiangtao LIU
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Patent number: 11723879Abstract: The present invention discloses a method for preparing a lycopene micro-capsule powder, wherein lycopene is fully mixed with an aqueous phase to obtain a lycopene emulsion, and the emulsion is then ground to a particle size less than 1 ?m, and spray dried. The aqueous phase comprises: a gelatin enzymatic hydrolysate with a molecular weight of 5,000-10,000 Da, disaccharide, polysaccharide, and an antioxidant. The disaccharide is one or more of sucrose, maltose and lactose; and the polysaccharide is one or more of pullulan and chitosan.Type: GrantFiled: June 8, 2020Date of Patent: August 15, 2023Assignee: Chenguang Biotech Group Co., Ltd.Inventors: Wei Gao, Jianzhong Xu, Xiangyu Yang, Hong Tian, Yamei Li, Xinchao Jia
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Publication number: 20230219872Abstract: Disclosed is an industrial extraction method of cannabidiol, pertaining to the field of medicine and chemical industry. The present invention aims to resolve the problems of difficulty in wax removal, low extraction rate of cannabidiol, and excessively high content of tetrahydrocannabinol during extraction using conventional solvents in the prior art. The extraction method employs raw material pretreatment, granulation, extraction, liquid-liquid extraction, decolorization, concentration, and other processes, such that wax removal from an extracted liquid is improved, the purity of a crude cannabidiol oil can be increased to 60%, and 40% of tetrahydrocannabinol can be removed. The method has high extraction yields and low costs, and can be implemented in large-scale industrial production.Type: ApplicationFiled: May 27, 2021Publication date: July 13, 2023Applicant: CHENGUANG BIOTECH GROUP CO., LTD.Inventors: Qingguo LU, Yunhe LIAN, Wei Gao, Yang LI, Hong TIAN
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Publication number: 20230194526Abstract: The disclosure belongs to the field of biotechnology, and in particular to a blocking ELISA kit for detecting an antibody to swine acute diarrhea syndrome coronavirus (SADS-CoV) N protein. The kit includes an enzyme plate coated with SADS-CoV N protein, an HRP-labeled mouse anti-SADS-CoV N protein monoclonal antibody (mAb), a positive serum control, and a negative serum control. The kit may detect positive sera diluted at 1:512, with no cross-reaction with positive sera against porcine epidemic diarrhea virus (PEDV), transmissible gasteroenteritis virus (TGEV) and porcine deltacoronavinis (PDCoV) etc., and the intrabatch and interbatch coefficient of variation is less than 10%. The comparison result with the indirect immunofluorescence test shows that the concordance rate of the blocking ELISA kit of the present disclosure is 99.6%, the Kappa value is 0.91, and the blocking ELISA method established by the present disclosure is highly consistent with IFA.Type: ApplicationFiled: July 8, 2022Publication date: June 22, 2023Inventors: QI WANG, LIYAN CAO, HAIXUE ZHENG, HONG TIAN, XIANGYU KONG, CONG YUAN, YUEYUE DUAN
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Lycopene colorant having fresh-keeping function, preparation method therefor and application thereof
Patent number: 11540537Abstract: Disclosed is a lycopene food colorant having a fresh-keeping function. The food colorant is prepared from the following raw materials in parts by weight: 1-3 parts of a lycopene crystal, 5-20 parts of an emulsifier, 0.5-5 parts of an antioxidant, 60-70 parts of glycerol, and 10-20 parts of water. The food colorant is prepared by mixing the raw materials and then emulsifying and grinding same. The granularity of the obtained lycopene colorant is moderate; the tone is suitable for coloring a minced fillet product; the lycopene colorant has high tinting strength, achieves a bright color, and has the effect of triggering myoglobin, so that the minced fillet product has a bright color and appears fresher; the lycopene colorant further has a fresh-keeping function and can kill some food microorganisms, so as to keep food fresh and prolong the shelf life.Type: GrantFiled: June 29, 2020Date of Patent: January 3, 2023Assignee: Chenguang Biotech Group Co., Ltd.Inventors: Jianzhong Xu, Xinchao Jia, Hong Tian, Wei Gao, Hongxia Wang, Lijuan Jiao -
Publication number: 20220031832Abstract: The disclosure provides a recombinant nucleic acid of Seneca valley virus, a recombinant vaccine strain and preparation method and use thereof, and relates to the technical field of genetic engineering. The disclosure provides the recombinant nucleic acid of Seneca valley virus, recombinant Seneca valley virus comprising the recombinant nucleic acid, recombinant Seneca valley virus encoded by the recombinant nucleic acid, recombinant Seneca valley virus vaccine strain comprising the recombinant Seneca valley virus and preparation method and use thereof. According to the disclosure, a vaccine strain characterized by high antigen production capacity, remarkably reduced pathogenicity (even having no pathogenicity to pigs), strong antibody induction activity, high immune protection rate is prepared. The vaccine strain remarkably improves the biological safety and can be used for preventing and controlling Seneca valley virus in China and the neighboring countries.Type: ApplicationFiled: May 24, 2021Publication date: February 3, 2022Applicant: Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural SciencesInventors: Haixue Zheng, Fan Yang, Zixiang Zhu, Weijun Cao, Hong Tian, Keshan Zhang, Ting Wei, Min Zheng, Wei Zhang, Wen Dang, Xusheng Ma, Dan Li, Yi Ru, Jijun He, Jianhong Guo, Xiangtao Liu
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Publication number: 20220017576Abstract: The present disclosure belongs to the technical field of biological products for veterinary medicine, and specifically relates to a recombinant foot-and-mouth disease virus (FMDV) with a reduced immunosuppressive activity, a preparation method and use thereof, and a recombinant vaccine strain. According to the present disclosure, it is firstly discovered that FMDV 3B protein has an immunosuppressive function, and key sites for exerting the immunosuppressive function are found. A recombinant FMDV vaccine strain with a lost immunosuppressive function in FMDV 3B protein is constructed by introducing amino acid mutations into three repeated copies of FMDV 3B protein.Type: ApplicationFiled: July 14, 2021Publication date: January 20, 2022Inventors: Haixue ZHENG, Fan YANG, Zixiang ZHU, Xiangle ZHANG, Weijun CAO, Congcong WANG, Kangli LI, Huisheng LIU, Hong TIAN, Keshan ZHANG, Xiangtao LIU
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Publication number: 20210230204Abstract: An industrialization method for comprehensive utilization of Stevia rebaudiana. The major improvement is in that the Stevia rebaudiana is extracted by using a high-concentration alcohol solution, then the extracted solution is purified by using an organic solvent, and the pH of the extracted solution is adjusted to be alkaline according to the acidic characteristic of chlorogenic acid to enable the chlorogenic acid to be formed into a salt and have an increased polarity so as to achieve effective separation of the chlorogenic acid and a glucoside component in an adsorption process. The method allows the high-quality stevioside and chlorogenic acid to be obtained, significantly improves the comprehensive utilization rate of Stevia rebaudiana, reduces the waste of natural Stevia rebaudiana resources, reduces the resource consumption in a production process, reduces waste discharge, and is a high-benefit green production process.Type: ApplicationFiled: March 30, 2021Publication date: July 29, 2021Applicant: Chenguang Biotech Group Co., Ltd.Inventors: Meili XU, Yunhe LIAN, Hong TIAN, Wei GAO, Yachao XU
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Publication number: 20210162041Abstract: A helper epitope peptide is obtained by means of replacing one or two amino acid residues in the helper T cell epitope PADRE with 4-nitrophenylalanine. The helper epitope peptide is effective for enhancing the immunogenicity of an antigen or antigenic epitope or for preparing or constructing a vaccine, and a fusion antigen formed by connecting the helper epitope peptide to an antigen or an antigenic epitope.Type: ApplicationFiled: April 19, 2019Publication date: June 3, 2021Inventors: Wenbing YAO, Hong TIAN, Yi XU, Yu HE, Xiangdong GAO
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Patent number: 10894081Abstract: The present disclosure relates to a foot-and-mouth disease virus vaccine composition, especially a recombinant bivalent vaccine composition against type O and type A foot-and-mouth disease viruses. The present disclosure further relates to a method for preparing the foot-and-mouth disease virus vaccine composition, and a use of the foot-and-mouth disease virus vaccine composition in preparing medicines for preventing and/or controlling foot-and-mouth disease in animals.Type: GrantFiled: March 23, 2018Date of Patent: January 19, 2021Assignee: LANZHOU VETERINARY RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCESInventors: Haixue Zheng, Fan Yang, Zixiang Zhu, Weijun Cao, Hong Tian, Keshan Zhang, Dan Li, Ye Jin, Jianhong Guo, Jijun He, Xuepeng Cai, Xiangtao Liu
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LYCOPENE COLORANT HAVING FRESH-KEEPING FUNCTION, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Publication number: 20200329747Abstract: Disclosed is a lycopene food colorant having a fresh-keeping function. The food colorant is prepared from the following raw materials in parts by weight: 1-3 parts of a lycopene crystal, 5-20 parts of an emulsifier, 0.5-5 parts of an antioxidant, 60-70 parts of glycerol, and 10-20 parts of water. The food colorant is prepared by mixing the raw materials and then emulsifying and grinding same. The granularity of the obtained lycopene colorant is moderate; the tone is suitable for coloring a minced fillet product; the lycopene colorant has high tinting strength, achieves a bright color, and has the effect of triggering myoglobin, so that the minced fillet product has a bright color and appears fresher; the lycopene colorant further has a fresh-keeping function and can kill some food microorganisms, so as to keep food fresh and prolong the shelf life.Type: ApplicationFiled: June 29, 2020Publication date: October 22, 2020Applicant: Chenguang Biotech Group Co., Ltd.Inventors: Jianzhong XU, Xinchao JIA, Hong TIAN, Wei GAO, Hongxia WANG, Lijuan JIAO -
Publication number: 20200297655Abstract: The present invention discloses a method for preparing a lycopene micro-capsule powder, wherein lycopene is fully mixed with an aqueous phase to obtain a lycopene emulsion, and the emulsion is then ground to a particle size less than 1 ?m, and spray dried. The aqueous phase comprises: a gelatin enzymatic hydrolysate with a molecular weight of 5,000-10,000 Da, disaccharide, polysaccharide, and an antioxidant. The disaccharide is one or more of sucrose, maltose and lactose; and the polysaccharide is one or more of pullulan and chitosan.Type: ApplicationFiled: June 8, 2020Publication date: September 24, 2020Applicant: Chenguang Biotech Group Co.,Ltd.Inventors: Wei GAO, Jianzhong XU, Xiangyu YANG, Hong TIAN, Yamei LI, Xinchao JIA