Abstract: Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the target cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis. The target cell may be a fibrotic cell.

Abstract: Provided is a four-directional extended intervertebral fusion cage device including a front support, a rear support, and four plates having front ends engaged with the front support and rear ends engaged with the rear support, and configured to slide up in four different directions on inclined surfaces of the front support and the rear support and increase a height and a width of the cage device simultaneously, when the front support and the rear support move toward each other, facing each other.

Abstract: Provided is a spinal implant having a unit structure printed by using a 3D printer, which is inserted between a vertebra and an adjacent vertebra and in which unit bodies constituted by at least one or more circular rings are repeated with a certain pattern. The spinal implant may implement elastic force like the existing vertebrae while bone fusion is performed as well as a state in which the bone fusion is completed after a procedure to obtain superior procedure results.

Abstract: A pedicle screw has quadruple screw threads capable of moving forward a long distance in a bone upon rotation. For a screw to be embedded in a dense cortical bone of a vertebra, the threads include relief screw threads, to strongly couple with bone tissue in the cortical bone. For a screw to be embedded in a cancellous bone of the vertebra, two lines of threads (odd or even) include relief screw threads while the other two lines of threads include intaglio screw threads, thereby more strongly coupling with relatively soft cancellous bone tissue. The threads are provided in the whole pedicle screw, to move forward at 4-fold higher speed than a single screw thread, and intaglio screw threads are formed at a position to which the cancellous bone is fixed, so that cancellous bone tissues penetrate between the intaglio threads, thereby strongly coupling to the cortical and cancellous bones.

Abstract: Provided is a spinal screw holder for a minimal invasive surgery. The spinal screw holder includes a first joint part having both penetrated ends, which is detachably coupled to a screw head fixed to a vertebra so as to be exposed to a predetermined height through an opening formed in a skin of a subject and a second joint part having both penetrated ends, which is coupled to an upper end of the first joint part and which is linearly movable in a direction that is away from the upper end of the first joint part and rotates to be bent with respect to the upper end of the first joint part after the second joint part is inserted through the opening in a state of being disposed in a straight line together with the first joint part.

Abstract: Disclosed herein is an intervertebral tensional artificial disc replacement, insertable between adjacent vertebrae, which includes an inferior plate engaging with a lower vertebra and providing elastic force to an upper vertebra, and a superior plate seated on an upper portion of the inferior plate to engage with the upper vertebra, the superior plate being rotatable right and left within a certain angular range depending on rotation of the upper vertebra. Since the adjacent vertebrae are supported by elastic force, it is possible to prevent abrasion due to frequent friction between upper and lower bodies of the artificial disc replacement. In addition, the intervertebral artificial disc replacement can engage well with a spine and move well by locating the central axis of motion of the intervertebral artificial disc replacement at a rearward position, similar to the central axis of the body's spinal motion.

Abstract: The present invention relates to an instrument for band coupling between spinous processes that comprises: a needle unit that is inserted through a cutaway insertion portion of a patient's abdomen and is discharged through a cutaway discharge portion of the abdomen while passing between a spinous process protruding from the spine and a neighboring spinous process; and a band unit that is detachably coupled to an end portion of the needle unit and has a predetermined level of tension, the band unit being disposed between the spinous process and the neighboring spinous process, outside the spinous process, and outside the neighboring spinous process to secure the spinous process and the neighboring spinous process together. Thanks to the relatively cheap and simple configuration, it is possible to effectively conduct a procedure irrespective of proficiency, acquire an optimal procedure result, and cope with various patients' body types.

Abstract: The present invention relates to an interspinous dynamic implant. Provided is an interspinous dynamic implant comprising: an upper plate which adheres to an upper spinous process; a lower plate which adheres to a lower spinous process; a movable part, coupled between the front portion of the upper plate and the front portion of the lower plate, for enabling the upper plate and the lower plate to move upwards, downwards, left and right within a certain range according to the movement of spinous processes; an upper spinous process coupling means for tightly coupling the upper plate to the upper spinous process; and a lower spinous process coupling means for tightly coupling the lower plate to the lower spinous process.

Abstract: Provided is a spinal implant having a unit structure printed by using a 3D printer, which is inserted between a vertebra and an adjacent vertebra and in which unit bodies constituted by at least one or more circular rings are repeated with a certain pattern. The spinal implant may implement elastic force like the existing vertebrae while bone fusion is performed as well as a state in which the bone fusion is completed after a procedure to obtain superior procedure results.

Abstract: A pedicle screw has quadruple screw threads capable of moving forward a long distance in a bone upon rotation. For a screw to be embedded in a dense cortical bone of a vertebra, the threads include relief screw threads, to strongly couple with bone tissue in the cortical bone. For a screw to be embedded in a cancellous bone of the vertebra, two lines of threads (odd or even) include relief screw threads while the other two lines of threads include intaglio screw threads, thereby more strongly coupling with relatively soft cancellous bone tissue. The threads are provided in the whole pedicle screw, to move forward at 4-fold higher speed than a single screw thread, and intaglio screw threads are formed at a position to which the cancellous bone is fixed, so that cancellous bone tissues penetrate between the intaglio threads, thereby strongly coupling to the cortical and cancellous bones.

Abstract: Provided are a rod inserter for fixing a pedicle screw. The rod inserter for fixing a pedicle screw, the rod inserter including a rotational support unit having a length corresponding to a radius of lordosis formed by lumbar of vertebrae of a subject person and of which a lower end is fixed and a rotational insertion unit having a length corresponding to the radius and having one end rotatably coupled to an upper end of the rotational support unit and the other end to which an arc-shaped rod is detachably coupled. Thus, the arc-shaped rods having lengths shapes different from each other according to the number of screws respectively fixed to the vertebrae of the subject person is coupled as one device to perform the operation.

Abstract: The present invention relates to an interspinous dynamic implant. Provided is an interspinous dynamic implant comprising: an upper plate which adheres to an upper spinous process; a lower plate which adheres to a lower spinous process; a movable part, coupled between the front portion of the upper plate and the front portion of the lower plate, for enabling the upper plate and the lower plate to move upwards, downwards, left and right within a certain range according to the movement of spinous processes; an upper spinous process coupling means for tightly coupling the upper plate to the upper spinous process; and a lower spinous process coupling means for tightly coupling the lower plate to the lower spinous process. The interspinous dynamic implant according to the present invention provides elasticity to the upper spinous process and the lower spinous process, thereby maintaining a space between the upper and lower spinous processes.

Abstract: The present invention relates to a spacer device for fixing a band between spinous processes, the spacer device comprising: a band unit which has a certain degree of tension and is disposed between a spinous process and an adjacent spinous process which protrude from the vertebrae, on the outer circumference of the spinous process and on the outer circumference of the adjacent spinous process so as to mutually fix the spinous process and the adjacent spinous process; and a spacer unit which is coupled to the band unit and is disposed in a space between the spinous process and the adjacent spinous process so as to fix the end of the band unit, wherein the spacer unit moves along the band unit from the outside of the body to the inside of the body in a state where the band unit penetrates the spacer unit, and thus the spacer unit is inserted into the space between the spinous process and the adjacent spinous process.

Abstract: The present invention relates to an interspinous integration type implant.

Abstract: The present invention relates to an instrument for band coupling between spinous processes that comprises: a needle unit that is inserted through a cutaway insertion portion of a patient's abdomen and is discharged through a cutaway discharge portion of the abdomen while passing between a spinous process protruding from the spine and a neighboring spinous process; and a band unit that is detachably coupled to an end portion of the needle unit and has a predetermined level of tension, the band unit being disposed between the spinous process and the neighboring spinous process, outside the spinous process, and outside the neighboring spinous process to secure the spinous process and the neighboring spinous process together. Thanks to the relatively cheap and simple configuration, it is possible to effectively conduct a procedure irrespective of proficiency, acquire an optimal procedure result, and cope with various patients' body types.

Abstract: A minimally invasive intervertebral body retaining cage insertion device is a cage insertion device for inserting a cage between adjacent vertebrae by using a screw driver for inserting a spine-retaining pedicle screw as a shaft.

Abstract: Provided is an intervertebral fusion cage combined with a fixing blade.

Abstract: A minimally invasive intervertebral body retaining cage insertion device is a cage insertion device for inserting a cage between adjacent vertebrae by using a screw driver for inserting a spine-retaining pedicle screw as a shaft.

Abstract: Provided are a rod inserter for fixing a pedicle screw. The rod inserter for fixing a pedicle screw, the rod inserter including a rotational support unit having a length corresponding to a radius of lordosis formed by lumbar of vertebrae of a subject person and of which a lower end is fixed and a rotational insertion unit having a length corresponding to the radius and having one end rotatably coupled to an upper end of the rotational support unit and the other end to which an arc-shaped rod is detachably coupled. Thus, the arc-shaped rods having lengths shapes different from each other according to the number of screws respectively fixed to the vertebrae of the subject person is coupled as one device to perform the operation.

Abstract: Disclosed herein is an intervertebral tensional artificial disc replacement, insertable between adjacent vertebrae, which includes an inferior plate engaging with a lower vertebra and providing elastic force to an upper vertebra, and a superior plate seated on an upper portion of the inferior plate to engage with the upper vertebra, the superior plate being rotatable right and left within a certain angular range depending on rotation of the upper vertebra. Since the adjacent vertebrae are supported by elastic force, it is possible to prevent abrasion due to frequent friction between upper and lower bodies of the artificial disc replacement. In addition, the intervertebral artificial disc replacement can engage well with a spine and move well by locating the central axis of motion of the intervertebral artificial disc replacement at a rearward position, similar to the central axis of the body's spinal motion.