Abstract: Disclosed are macrocyclic peptide compounds or a salt thereof, which are useful as modulators of TNF?, and pharmaceutical compositions comprising such compounds. These compounds may be useful in treating cancers, inflammatory and autoimmune diseases.

Abstract: The present disclosure generally relates to novel multiple target inhibitor of tyrosine kinases (TKs) which can suppress angiogenesis, metastasis, oncogenesis, and/or immune regulation activities by inhibiting TKs and have very potent immunomodulatory activity. The present disclosure also relates to a method of using the tyrosine kinase inhibitors, alone or in combination with HDAC inhibitor, for the treatment of cancers, in particular in cancer immunotherapy, by regulating the tumor microenvironment, including reducing tumor hypoxia, reducing lactic acid accumulation, activating CTL, inhibiting the number and activity of immunosuppressive cells, finally obtaining superior anti-cancer benefits and/or producing lasting immune memory.

Abstract: Optical devices and methods of manufacture are presented herein. In an embodiment, an apparatus is provided that includes a notch filter, an optical signal detector positioned adjacent to the notch filter, and a mirror positioned to adjacent to the notch filter.

Abstract: This application provides a packet sending method, a network device, and a system. The method includes: A first network device receives an advertisement message sent by a second network device, where the advertisement message includes segment routing policy SR policy information and traffic feature information, and the SR policy information includes a segment identifier list SID list. The first network device establishes a correspondence between the traffic feature information and the SID list according to the advertisement message, where the correspondence is used to guide forwarding of a packet including the traffic feature information.

Abstract: A gait evaluating system including a processor is provided. The processor identifies whether a gait type of the user belongs to a normal gait, a non-neuropathic gait or a neuropathic gait based on step feature values of a user and walking limb feature values of the user. In response to that the gait type of the user belongs to the non-neuropathic gait, the processor controls the display panel to display a first auxiliary information, a second auxiliary information, and a third auxiliary information. The first auxiliary information indicates a potential sarcopenia of the user. The second auxiliary information indicates a dietary guideline for muscle building and muscle strengthening. The third auxiliary information shows a motion instruction video for regaining or maintaining muscle strength of the user.

Abstract: The present disclosure generally relates to compounds class I HDAC inhibitors, their production and applications. The compounds possess epigenetic immunomodulatory activities in the tumor microenvironment (TME) and thus inhibit growth of tumor cells.

Abstract: Implementations relate to updating agricultural records that include inferences gathered by one or more sensors deployed at an agricultural location. The records are matched to mapping tiles of a mapping application and the mapping tile records are updated according to the updated data that was received. Implementations further include identifying parent tiles to each of the updated records, where a parent tile is an aggregation of multiple mapping tiles that can be utilized by a mapping application to render an interface that allows a user to view the data with varying degrees of granularity.

Abstract: A preparation method of a polytetrafluoroethylene (PTFE)-based membrane for preventing and removing ices covering wind turbine blades is provided and the method comprises: preparing a membrane into a PTFE rod material with polymerized monomers by using monomer polymerization methods such as blending, pre-compressing and pushing; making the membrane into a PTFE-based homogeneous membrane with micropores and nano and micron scale concave-convex geometrical ultra-structure morphologies under the condition that the membrane is cracked to generate a laminar exfoliated fabric-like structure in the hot calendaring process of the PTFE rod material by using a hot calendaring and fusion polymerization method; and applying the PTFE-based homogeneous membrane to blades of a large wind turbine in operation.

Abstract: A preparation method of a polytetrafluoroethylene (PTFE)-based nano functional composite membrane and use is provided. The PTFE-based nano functional composite membrane can be applied to prevention and resistance of icing of various types of wind turbine generator blades in winter and salt spray corrosion resistance of wind turbine blades, in the meantime, can improve the aerodynamic performance of wind turbine blade airfoils and enhance the whole surface strength of the blade and protect the blade from undergoing aging erosion, and is a new-generation multi-functional brand-new composite membrane material which can be directly explored and applied to the industrial fields of preventing adhesion and corrosion of marine fouling organisms on steel pipe piles of offshore wind power and offshore platforms, avoiding snowing and icing of high-voltage transmission towers and cables, protecting snowing and icing of bridges (stay cables and suspension cables) and the like.

Abstract: A method for nano-depth surface activation of a PTFE-based membrane and relates to the technical field of polymer composites is disclosed. The method comprises the following steps: covering a functional surface of a PTFE-based nano functional composite membrane, performing surface activation treatment on a single surface of the membrane to which a bonding adhesive is applied, and migrating and complexing a high-toughness cold bonding adhesive tape on the membrane surface, with an activated structure layer, of the PTFE-based nano functional composite membrane through a mechanical adhesive applying device to form an adhesive-membrane complex. An extremely strong affinity and a high-strength bonding performance are generated between the membrane and the adhesive, and the adhesive-membrane complex is formed. Integration of membrane/adhesive bonding complexing, membrane/membrane bonding complexing and membrane/adhesive layer bonding is realized.

Abstract: A high-temperature high-linear-pressure micro-eutectic method for enhancing a strength of a polytetrafluoroethylene (PTFE)-based membrane is disclosed. The method comprises the following steps: pushing a PTFE-based nano functional composite membrane forwards at a speed of 6-8 m/min in a high-temperature high-linear-pressure micro-eutectic cavity with a length of 1.5 m at a temperature of 380° C., controlling a linear pressure of a surface of the PTFE-based membrane to be 50-80 N/m, and under a coiling traction of a membrane coiling roller outside the cavity, enabling membrane molecular chains to shrink and generate eutectic phases, wherein multiple micro-eutectic molecular structures are arranged in parallel, and the PTFE-based nano functional composite membrane has a density of 2.

Abstract: In accordance with an embodiment, systems and methods are provided for two-tier reporting for cloud computing realms. An exemplary method can deploy a central instance of an analytics service in a central cloud realm. The method can further deploy a respective instance of the analytics service in each of a plurality of cloud realms. The method can implement a respective different data pipeline for each deployed respective instance of the analytics service, wherein a respective different data pipeline is configured to perform at least one of ingest or transform data for the deployed respective instance of the analytics service, said data being descriptive of use of services associated with a respective cloud realm of the plurality of cloud realms.

Abstract: This application discloses a route advertisement method and a related device. To reduce IP address resources and reduce configuration and maintenance costs of a network device, it is not required that all network devices in a network enable an IPV4/IPv6 dual-stack function, and the network device in the network may enable only an IPV4 or IPv6 single-stack function to bear IPv4 and IPv6 services. A route advertisement packet advertised by the network device and used to advertise an IPv4 route can include routing information corresponding to an IPV6 address, or a route advertisement packet used to advertise an IPV6 route can include routing information corresponding to an IPv4 address.

Abstract: The disclosure provides a catenary icing detection method based on infrared imaging and meteorological monitoring. In the disclosure, infrared illumination is used to detect the target, real-time images of the target are obtained through an infrared imaging sensor, and meteorological data are synchronously obtained through a meteorological monitoring unit, and normalized fusion processing is performed; the data are stored in a front-end edge computing unit, and through the deep learning model, the states of water accumulation, snow accumulation and icing of the target are automatically identified, and then sent to a background system through a transmission unit.

Abstract: The disclosure provides a catenary icing detection method based on infrared imaging and meteorological monitoring. In the disclosure, infrared illumination is used to detect the target, real-time images of the target are obtained through an infrared imaging sensor, and meteorological data are synchronously obtained through a meteorological monitoring unit, and normalized fusion processing is performed; the data are stored in a front-end edge computing unit, and through the deep learning model, the states of water accumulation, snow accumulation and icing of the target are automatically identified, and then sent to a background system through a transmission unit.

Abstract: An apparatus, includes a PCB, a semiconductor package that includes a substrate and a stiffener with an opening, and at least one connection component. The stiffener is disposed on a top surface of the PCB. The at least one connection component is configured to connect the PCB to the semiconductor package. The at least one connection component may include another PCB that is disposed on the substrate within the opening of the stiffener and on the PCB. The at least one connection component may include an array of connectors that are disposed on the substrate within the opening of the stiffener, and may include a socket disposed on the PCB. The at least one connection component may include a BGA that is disposed on the substrate within the opening of the stiffener and on the PCB and on a pedestal portion of a surface of the PCB.

Abstract: A crane counterweight block alignment detection and control method, a crane counterweight block alignment detection and control device, and a crane. The crane counterweight block alignment detection and control method comprise: a counterweight block being provided with mounting holes for matching with positioning pins on a crane, detecting the center position of the counterweight block, and calculating the relative offset between the center position and the position of the positioning pins; detecting the relative positions of the mounting holes in the counterweight block and the positioning pins, and calculating, according to the positions, a relative rotation angle of the counterweight block for aligning the mounting holes with the positioning pins; and controlling, according to the relative offset and relative rotation angle, the movement of the counterweight block to enable the mounting holes in the counterweight block to be aligned with and installed onto the positioning pins.

Abstract: A control circuit for a switching power converter is disclosed herein. The control circuit includes a power input terminal, a switching step-down regulator module, and a low dropout linear regulator module. The power input terminal is configured to receive an input signal. The switching step-down regulator module has a step-down regulating input terminal and a step-down output terminal. The step-down regulating input terminal is coupled to the power input terminal, and the switching step-down regulator module is configured to provide a step-down output voltage at the step-down output terminal. The low dropout linear regulator module is coupled to the power input terminal and the step-down output terminal, and is configured to be powered by the power input terminal in a first operation period and be powered by the step-down output voltage in a second operation period.

Abstract: A manufacturing system includes a substrate disposed on a conveyer system. The conveyer system includes a pair of side supports. The substrate is moved on the conveyer system until the substrate is disposed over a bottom support block. The bottom support block is raised to physically contact the substrate. A transfer arm module is provided. The transfer arm module includes a flat bottom surface and an opening formed in the flat bottom surface. The transfer arm module is disposed with the flat bottom surface physically contacting the substrate opposite the bottom support block. A vacuum is enabled through the opening of the transfer arm module. The substrate is lifted off the bottom support block using the vacuum. The substrate is moved over a printing pallet using the transfer arm module. The vacuum is disabled when the substrate is in a positioning area of the printing pallet.