Abstract: Applications of different configurations of novel glucagon peptide 1 with fatty acid modification or nonmodification in the treatment of T2D or the pancreas protection are provided. The dimer of the present disclosure is formed by two identical cysteine-containing GLP-1 monomers through a disulfide bond. The H-like GLP-1 homodimer (disulfide bond is inside chains) showed remarkable increase in hypoglycemic duration without reducing specific activity. The GLP-1 dimer provided has an in-vivo effective duration of up to 19 days, which significantly prolonged compared with that of the positive control drug Liraglutide with 3 days of effective duration, or thereby greatly promoting the technical advancement in long-acting GLP-1 drugs and facilitating their clinical applications and business. Meanwhile the U-like homodimer (disulfide bond is at the C-terminus) does not affect blood glucose, but can obviously protect pancreatic exocrine cells such as acini and ducts, and improve pancreas function.

Abstract: A computer-implemented technique performs machine learning that bypasses the traditional design of loss functions. The technique includes receiving plural instances of gradient objective information. Each of the plural instances includes a particular combination of plural gradient elements. The technique produces plural sets of machine-trained parameter values using the plural respective instances of gradient objective information. The technique performs this operation based on the plural instances of gradient objective information as given, without calculating the plural instances of gradient objective information using loss functions. The technique then measures performance of the plural sets of machine-trained parameter values in an application system. Based on the measured performance, the technique provides output information that identifies a particular set of machine-trained parameter values that satisfies a prescribed test.

Abstract: A display device includes a support structure and back cover coupled to the support structure. The support structure includes a support frame, a positioning assembly, a connecting structure coupled to the back cover and the positioning assembly, and a rotating member including a hook portion and coupled to the support frame and rotationally coupled to the positioning assembly. The back cover includes a sliding rail protruding from a side thereof adjacent to the support frame. When the support frame rotates parallel to the back cover from a first position to a second position, the hook portion moves from one end of the sliding rail toward the sliding rail until the hook portion is hooked onto the sliding rail and the support structure is fixed to the back cover.

Abstract: A display device includes a support structure and back cover coupled to the support structure. The support structure includes a support frame, a positioning assembly, a connecting structure coupled to the back cover and the positioning assembly, and a rotating member including a hook portion and coupled to the support frame and rotationally coupled to the positioning assembly. The back cover includes a sliding rail protruding from a side thereof adjacent to the support frame. When the support frame rotates parallel to the back cover from a first position to a second position, the hook portion moves from one end of the sliding rail toward the sliding rail until the hook portion is hooked onto the sliding rail and the support structure is fixed to the back cover.

Abstract: A computation apparatus, a resource allocation method thereof and a communication system are provided. The communication system includes at least two computation apparatuses and an integration apparatus. The computation apparatuses transmit request contents, and each of the request contents is related to data computation. The integration apparatus integrates the request contents of the computation apparatuses into a computation demand, and broadcasts the computation demand. Each of the computation apparatuses obtains a resource allocation of all of the computation apparatuses according to the computation demand. Moreover, each of the computation apparatuses performs the data computation related to the request content according to a resource allocation of itself. In this way, a low-latency service is achieved, and reliability is improved.

Abstract: A splice joint is for joining first and second synchronous drive belt ends, of the belt type comprising a reinforcement material layer covering a base layer formed from a first thermoplastic material. The joint comprises a fused portion of the base layer of the first and second belt ends that define a splice region. At least one coating layer of thermoplastic material overlaps the reinforcement layer of the end portions in the splice region. The coating layer is comprised of a second elastomeric material intended to melt and penetrate into interstices of the reinforcement material layer while within the mold press. Migration of the base layer material through the reinforcement material layer to the pulley-engaging outer surface is thereby inhibited. The second elastomeric material composing the coating layer may be selected to provide desired frictional and wear characteristics.

Abstract: A splice joint is for joining first and second synchronous drive belt ends, of the belt type comprising a reinforcement material layer covering a base layer formed from a first thermoplastic material. The joint comprises a fused portion of the base layer of the first and second belt ends that define a splice region. At least one coating layer of thermoplastic material overlaps the reinforcement layer of the end portions in the splice region. The coating layer is comprised of a second elastomeric material intended to melt and penetrate into interstices of the reinforcement material layer while within the mold press. Migration of the base layer material through the reinforcement material layer to the pulley-engaging outer surface is thereby inhibited. The second elastomeric material composing the coating layer may be selected to provide desired frictional and wear characteristics.