Abstract: The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

Abstract: A clip pushing structure for a clip applier, which is used to install and push clips. The clip pushing structure comprises: a nail mounting groove piece which has a receiving slot, wherein the clips are placed in the receiving slot of the nail mounting groove piece in a continuous abutting manner; a screw-in ladder member which has a nail-pushing part and a plurality of pushed parts, a pitch being formed between every two pushed parts; a nail pushing member which has a body, a front pushing part that may push the foremost clip, and a rear pushing part that may push each pushed part of the screw-in ladder member; and a clamping jaw which penetrates a clamping jaw assembly, the clamping jaw having two arms which each have a convex part and abut against a left side wall and a right side wall of the clamping jaw assembly.

Abstract: An operating structure of a surgical clip applier is provided to drive a clip clamping unit. The operating structure of the surgical clip applier comprises: a body; a front driving element for driving the clip clamping unit; a restoring spring for driving the front driving element to move backward; a press-control element pivotally connected to the body; a front driving arm pivotally connected to the press-control element; and a lower driving arm with two ends pivotally connected to the body and the front driving arm, respectively, to drive the front driving element to move forward.

Abstract: An operating structure of a surgical clip applier is provided to drive a clip clamping unit. The operating structure of the surgical clip applier comprises: a body; a front driving element for driving the clip clamping unit; a restoring spring for driving the front driving element to move backward; a press-control element pivotally connected to the body; a front driving arm pivotally connected to the press-control element; and a lower driving arm with two ends pivotally connected to the body and the front driving arm, respectively, to drive the front driving element to move forward.