Patents by Inventor Hong-Yu Li

Hong-Yu Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240190903
    Abstract: Compounds of Formula (IA) (Targeting Moiety)-(Linker)-(Protease Ligand)??(IA), where the targeting moiety is an oligonucleotide capable of binding a target protein and the protease ligand is a ligand capable of binding a protease, and methods for the use thereof are provided. Also provided are compounds of Formula (IB) (Targeting Moiety)-(Linker)-(Protease Ligand or E3 Ligase Ligand)??(IB), where the targeting moiety is an oligonucleotide capable of binding a target protein, the protease ligand is a ligand capable of binding a protease, and the E3 ligase ligand is a ligand capable of binding an E3 ligase, and methods for the use thereof are provided.
    Type: Application
    Filed: February 25, 2022
    Publication date: June 13, 2024
    Inventors: Haojie HUANG, Jingwei SHAO, Wei YAN, Yuqian YAN, Hong-yu LI
  • Publication number: 20240066033
    Abstract: Disclosed herein are RNA methyltransferase inhibitors and methods of using and making the same. The inhibitors may be used in a method for the treatment of a subject in need of a treatment for a cancer by administering an effective amount of the RNA methyltransferase inhibitor and an effective amount of a DNA damaging agent to the subject.
    Type: Application
    Filed: August 9, 2021
    Publication date: February 29, 2024
    Inventors: Hong-yu Li, Wei Yan, Li Lan
  • Publication number: 20240059685
    Abstract: Disclosed herein are Piezo1 agonists. Also disclosed herein are methods of stimulating tissue anabolism in a subject comprising administering an effective amount of a Piezo1 agonist and methods for chemically mimicking mechanical stimulation of a cell expressing Piezo1 comprising contacting a cell expressing Piezo1 with an effective amount of a Piezo1 agonist.
    Type: Application
    Filed: October 5, 2020
    Publication date: February 22, 2024
    Inventors: Hong-yu Li, Jinhu Xiong, Wei Yan, Charles O'Brien, Maria Schuller De Almeida
  • Publication number: 20240000784
    Abstract: Disclosed herein are RNA methyltransferase inhibitors and methods of using the same. The inhibitors may be used in a method for the treatment of a subject in need of a treatment for a cancer by administering an effective amount of an RNA methyl-transferase inhibitor to the subject.
    Type: Application
    Filed: August 9, 2021
    Publication date: January 4, 2024
    Inventors: Hong-yu Li, Wei Yan, Li Lan
  • Publication number: 20230394811
    Abstract: A training method includes following steps. A converted image group is generated by a first generator included in the first stage generative adversarial network (GAN) according to a first input image group. A reconstructed image group is generated by a second generator included in the first stage GAN according to the converted image group. The first stage GAN is updated according the reconstructed image group and the first input image group. A sampling block is added into a first stage trained GAN to form a second stage GAN. Progressively training and growing the second stage GAN network at multiple stages according to a second input image group to a last input image group to generate a last stage trained GAN.
    Type: Application
    Filed: June 1, 2023
    Publication date: December 7, 2023
    Inventors: Yung-Hui LI, Hong-Yu LI
  • Publication number: 20220304990
    Abstract: Mi-2? inhibitors and methods of using the same are disclosed. The methods comprise administering an effective amount of a Mi-2? inhibitor to the subject or contacting a cancer cell or a tumor with an effective amount of a Mi-2? inhibitor.
    Type: Application
    Filed: March 16, 2022
    Publication date: September 29, 2022
    Inventors: Hong-yu LI, Zhengyu WANG, Jingwei SHAO, Rutao CUI
  • Patent number: 9988371
    Abstract: The invention relates to compounds of the formula (VIII) wherein the moieties R1, R2, R3, R4, and R5 are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: June 5, 2018
    Assignees: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, UNIVERSITA' FEDERICO II
    Inventors: Hong-yu Li, Brendan Frett, Massimo Santoro, Francesca Carlomagno
  • Publication number: 20170101401
    Abstract: The invention relates to compounds of the formula (VIII) wherein the moieties R1, R2, R3, R4, and R5 are as defined in the specification, and salts thereof, as well as their use, methods of use for them, methods of their synthesis, and the like. The compounds are protein tyrosine kinase inhibitors and can be used in the treatment of various cancer diseases and cancer-associated pain.
    Type: Application
    Filed: June 3, 2015
    Publication date: April 13, 2017
    Applicants: The Arizona Board of Regents, on Behalf of the University of Arizona, Universita' Federico II
    Inventors: Hong-yu Li, Brendan Frett, Massimo Santoro, Francesca Carlomagno
  • Patent number: 8268869
    Abstract: The present invention provides vinyl indazolyl compounds useful in the treatment of cancer.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: September 18, 2012
    Assignee: Eli Lilly and Company
    Inventors: Daohong Chen, Hong-Yu Li, Genshi Zhao
  • Patent number: 8201746
    Abstract: An on-chip antenna fabricated on a chip for wireless communication is disclosed. The on-chip antenna includes a first dielectric layer arranged on a surface of the chip of the radio frequency identification tag, a grounded shielding layer arranged on the first dielectric layer, a second dielectric layer arranged on the grounded shielding layer, and a planar antenna arranged on the second dielectric layer above the grounded shielding layer. A radio frequency identification tag with an on-chip antenna and a method of fabricating an on-chip antenna on a chip for wireless communication are also disclosed.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: June 19, 2012
    Assignee: Agency for Science, Technology and Research
    Inventors: Li Hui Guo, Hong Yu Li, Min Tang
  • Patent number: 8114872
    Abstract: The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: February 14, 2012
    Assignee: Eli Lilly and Company
    Inventors: Joyce Z. Crich, Delu Jiang, Hong-Yu Li, William Thomas McMillen, Jason Scott Sawyer, Melissa Kate Slater, Yan Wang, James Robert Henry, Hong Hu, Sachin Govindlal Maniar
  • Patent number: 8101628
    Abstract: The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. wherein: R1 hydrogen, hydroxy, halo, methyl, C1-C2 alkoxy, amino, or methylamino; R2 is hydrogen, halo, or cyano; R3 is hydrogen or halo; R4 is hydrogen, halo, or methyl; provided that at least two of R1, R2, R3, and R4 are hydrogen; R5 is hydrogen, halo, or methyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: January 24, 2012
    Assignee: Eli Lilly and Company
    Inventors: Harold Burns Brooks, Joyce Z. Crich, James Robert Henry, Hong-Yu Li, Melissa Kate Slater, Yan Wang
  • Patent number: 8063035
    Abstract: The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: November 22, 2011
    Assignee: Eli Lilly and Company
    Inventors: Joyce Z. Crich, James Robert Henry, Hong Hu, Delu Jiang, Hong-Yu Li, William Thomas McMillen, Jason Scott Sawyer, Melissa Kate Slater, Yan Wang
  • Patent number: 8063212
    Abstract: The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. Formula I wherein: R1 is aminomethyl, (C1-C3 alkyl)aminomethyl, di(C1-C2 alkyl)aminomethyl, N-ethyl-N-methyl-aminomethyl, 1-aminoethyl, 1-((C1-C2 alkyl)amino)-ethyl, 3,3,3-trifluoro-propylaminomethyl, ethynyl, 2-hydroxy-ethoxy, 2-hydroxyethylaminomethyl, 2-cyanoethylaminomethyl, morpholin-4-ylmethyl, methoxymethoxymethyl, cyclopropyl, 1-azetidinylmethyl, 1-pyrrolidinylmethyl, or 1,3-dioxolan-2-yl; R2 is hydrogen or halo; R3 is hydrogen or halo; provided that at least one of R2 and R3 is hydrogen; R4 is hydrogen, methyl, or halo; and is a single bond that is either present or absent, or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: November 22, 2011
    Assignee: Eli Lilly and Company
    Inventors: Harold Burns Brooks, Joyce Z. Crich, James Robert Henry, Hong-Yu Li, Jason Scott Sawyer, Yan Wang
  • Publication number: 20110036912
    Abstract: An on-chip antenna fabricated on a chip for wireless communication is disclosed. The on-chip antenna includes a first dielectric layer arranged on a surface of the chip of the radio frequency identification tag, a grounded shielding layer arranged on the first dielectric layer, a second dielectric layer arranged on the grounded shielding layer, and a planar antenna arranged on the second dielectric layer above the grounded shielding layer. A radio frequency identification tag with an on-chip antenna and a method of fabricating an on-chip antenna on a chip for wireless communication are also disclosed.
    Type: Application
    Filed: January 24, 2007
    Publication date: February 17, 2011
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY
    Inventors: Li Hui Guo, Hong Yu Li, Min Tang
  • Publication number: 20100286209
    Abstract: The present invention provides vinyl indazolyl compounds useful in the treatment of cancer.
    Type: Application
    Filed: May 4, 2010
    Publication date: November 11, 2010
    Inventors: Daohong Chen, Hong-Yu Li, Genshi Zhao
  • Publication number: 20100130466
    Abstract: The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
    Type: Application
    Filed: May 7, 2008
    Publication date: May 27, 2010
    Inventors: Harold Burns Brooks, Joyce Z. Crich, Delu Jiang, Hong-Yu Li, William Thomas McMillen, Jason Scott Sawyer, Melissa Kate Slater, Yan Wang, James Robert Henry, Hong Hu, Sachin Govindlal Maniar
  • Publication number: 20100087431
    Abstract: The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
    Type: Application
    Filed: May 7, 2008
    Publication date: April 8, 2010
    Inventors: Harold Burns Brooks, Joyce Z. Crich, James Robert Henry, Hong Hu, Delu Jiang, Hong-Yu Li, William Thomas McMillen, Jason Scott Sawyer, Melissa Kate Slater, Yan Wang
  • Publication number: 20100081641
    Abstract: The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. Formula I wherein: R1 is aminomethyl, (C1-C3 alkyl)aminomethyl, di(C1-C2 alkyl)aminomethyl, N-ethyl-N-methyl-aminomethyl, 1-aminoethyl, 1-((C1-C2 alkyl)amino)-ethyl, 3,3,3-trifluoro-propylaminomethyl, ethynyl, 2-hydroxy-ethoxy, 2-hydroxyethylaminomethyl, 2-cyanoethylaminomethyl, mopholin-4-ylmethyl, methoxymethoxymethyl, cyclopropyl, 1-azetidinylmethyl, 1-pyrrolidinylmethyl, or 1,3-dioxolan-2-yl; R2 is hydrogen or halo; R3 is hydrogen or halo; provided that at least one of R2 and R3 is hydrogen; R4 is hydrogen, methyl, or halo; and is a single bond that is either present or absent, or pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 11, 2007
    Publication date: April 1, 2010
    Inventors: Harold Burns Brooks, Joyce Z. Crich, James Robert Henry, Hong-Yu Li, Jason Scott Sawyer, Yan Wang
  • Publication number: 20100076001
    Abstract: The present invention provides novel imidazolidinonyl aminopyrimidine compounds believed to have clinical use for treatment of cancer through inhibiting Plk1. wherein: R1 hydrogen, hydroxy, halo, methyl, C1-C2 alkoxy, amino, or methylamino; R2 is hydrogen, halo, or cyano; R3 is hydrogen or halo; R4 is hydrogen, halo, or methyl; provided that at least two of R1, R2, R3, and R4 are hydrogen; R5 is hydrogen, halo, or methyl; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 11, 2007
    Publication date: March 25, 2010
    Inventors: Harold Burns Brooks, Joyce Z. Crich, James Robert Henry, Hong-Yu Li, Melissa Kate Slater, Yan Wang