Abstract: A well cementing method is described for improving cementing quality by controlling the hydration heat of cement slurry. By controlling the degree and/or rate of hydration heat release from cement slurry, the method improves the hydration heat release during formation of cement with curing of cement slurry, improves the binding quality between the cement and the interfaces, and in turn improves the cementing quality at the open hole section and/or the overlap section. The cementing method improves cementing quality of oil and gas wells and reduces the risk of annular pressure.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: The present disclosure provides a safe puncture needle, and relates to the technical field of medical devices, which comprises a needle holder, a base and a needle tubing, wherein the needle tubing comprises a needle tubing body and a needle tubing tip having a bent structure, the base comprises a base body and a guide block, the base body is provided with a second inner space, the base body is provided with a first through-hole and a second through-hole communicating with the second inner space, the guide block is provided with a third through-hole, the needle tubing body passes through the first through-hole and the third through-hole and is slidably connected to the guide block, and the needle tubing tip retracts from the second through-hole.

Abstract: A method of making solid oxidesolid oxide electrolyte membrane comprises steps (S1)-(S5). Step (S1), mixing a high molecular polymer and a first solvent to form a first mixed slurry; and homogenizing the first mixed slurry, to obtain a reagent A. Step (S2), mixing an oxide powder, a dispersant and a second solvent to form a second mixed slurry, treating the second mixed slurry, to obtain a reagent B. Step (S3), adding a protective agent into the reagent B to form a third mixed slurry, and homogenizing the third mixed slurry to obtain a reagent C. Step (S4), mixing the reagent A and the reagent C to form a fourth mixed slurry, and treating the fourth mixed slurry a fifth mixed slurry; and homogenizating the fifth mixed slurry to form a solid electrolyte slurry. And step (S5), producing the solid oxidesolid oxide electrolyte membrane by a coating process.

Abstract: An electronic device is provided. The electronic device includes a first substrate and a first pattern layer. The first substrate has a first surface and a second surface opposite to each other. The first pattern layer is disposed on the first surface and includes a first grid region and a second grid region. The first grid region includes multiple first grids. The second grid region includes multiple second grids. The first grid region is connected to the second grid region. One of the first grid and the second grid includes a metal grid. The other one of the first grid and the second grid includes a non-metal grid. The electronic device of the embodiment of the disclosure can improve appearance.

Abstract: The present application provides a flame-retardant electrolyte. The flame-retardant electrolyte includes a specific solvent; a lithium salt; and a fluorinated solvent. The specific solvent is carbonate solvent, ether solvent, succinonitrile, sulfolane, tetraglyme, ionic liquid or a combination thereof. Or, the flame-retardant electrolyte comprises 1-Butyl-1-methylpyrrolidinium bis (trifluoromethylsulfonyl)imide, lithium salt, and carbonate solvent.

Abstract: A method for manufacturing complex Si—C cathode base units includes the steps of: pulverizing a graphene block; mixing the plurality of graphene pieces with ethanol and first high molecular material; dispersing and pulverizing powders of silicon, and silicon oxide (SiOx) into a plurality of complex monomers; and then they being mixed with high molecular graphene recipe gel solution; spraying and drying Si—C solution to form with first order Si—C nanoparticles; a plurality of buffer spaces being formed in the plurality of graphene pieces; mixing first order SIC nanoparticles, second high molecular material, and a small amount of nanometer carbon tubes and then calcined them; the first order SiC nanoparticles, the second high molecular material and the nanometer carbon tubes being shaped or being sprayed and dried; and finally, calcining them to form as third order SIC nanoparticles which is the complex Si—C based unit.

Abstract: A horizontal grinder rotor includes a grinding ring, multiple blades, and a center body. The grinding ring, the multiple blades and the central body are formed by 3D printing. The multiple blades are located between the grinding ring and the central body, and the multiple blades are arranged at intervals. The multiple blades are arranged in pairs and symmetrical with respect to the central body, and the horizontal grinder rotor further comprises one or more pins, the one or more pins are provided on at least one side of each of the multiple blades.

Abstract: A method of making a silicon-carbon pre-lithium composite anode material is provided. The method includes: nanoizing silicon materials to obtain nano-silicon particles, adding carbon materials and polymer into the nano-silicon particles for homogenization treatment to obtain a silicon-carbon composite; providing a pre-lithium nanomaterial; mixing the silicon-carbon composite and the pre-lithium nanomaterial to granulate to obtain a silicon-carbon pre-lithium composite precursor; and sintering the silicon-carbon pre-lithium composite precursor.

Abstract: The present application provides a carbonate-based electrolyte. The carbonate-based electrolyte includes a carbonate, an ether, a lithium salt, a lithium nitrate, and a planar macrocyclic compound. The present application further provides a method for making the carbonate-based electrolyte and a lithium metal battery using the carbonate-based electrolyte.

Abstract: A touch display panel includes a light-emitting display layer, first touch electrodes, a color resist layer, and second touch electrodes. The light-emitting display layer includes a plurality of light-emitting units arranged in an array; the first touch electrodes are located on the side of the light-emitting display layer facing a light-emitting surface of the touch display panel, and are arranged in a first direction parallel to the touch display panel; the color resist layer includes a plurality of color resist units arranged in an array; the color resist units are arranged right opposite to the light-emitting units, and the color resist layer and the first touch electrodes are arranged side by side; the second touch electrodes are located on the side of the light-emitting display layer facing the light-emitting surface of the touch display panel, and are arranged in a second direction parallel to the touch display panel.

Abstract: An element-doped silicon-carbon composite negative electrode material is provided. The negative electrode material comprises a plurality of element-doped silicon-carbon composite negative electrode material particles, and each them comprises an element-doped silicon nanoparticle, a first carbon coating layer and a second carbon coating layer. The element-doped silicon nanoparticle is a core, and the first carbon coating layer is coated on the element-doped silicon nanoparticle, the second carbon coating layer covers the first carbon coating layer. The dopant element comprises at least one of a group IIIA element, a group VA element and a transition metal element. A method of preparing the element-doped silicon-carbon composite negative electrode material is further provided.

Abstract: The disclosure provides a composite cathode for a solid-state battery, which includes a composite layer and a solid electrolyte layer. The composite layer includes a cathode sheet, an interface layer and an ion conductor. The interface layer is disposed on the cathode sheet. The ion conductor is disposed between the cathode sheet and the interface layer, or dispersed in the cathode sheet and the interface layer. The solid electrolyte layer is disposed on the composite layer.

Abstract: A semiconductor device package includes a substrate, a first electronic component, a second electronic component, a package body and a shield. The substrate has a first surface and a second surface opposite to the first surface. The substrate defines a cavity from the second surface extending into the substrate. The first electronic component is disposed on the first surface of the substrate. The second electronic component is disposed within the cavity of the substrate. The package body is disposed on a portion of the first surface of the substrate and covers the first electronic component. The shield is disposed on external surfaces of the package body.

Abstract: A battery cathode material includes cathode material, ceramic material, and carbon-containing gel. The cathode material includes lithium nickel cobalt manganese oxide (NCM), lithium nickel cobalt aluminum oxide (NCA), lithium nickel manganese oxide (LNMO), lithium cobalt oxide (LCO), lithium iron phosphate (LFP), lithium nickel cobalt manganese aluminum oxide (NCMA), or combinations thereof. The ceramic material surrounds the cathode material, and includes gallium, aluminum, or tantalum doped lithium lanthanum zirconium oxide (LLZO), lithium zinc titanate (LZTO), lithium aluminum titanium phosphate (LATP), lithium-zirconium phosphate (LZPO), lithium zirconate (LZO), or combinations thereof.

Abstract: This disclosure provides a gene expression-based method for determining a virally-infected subject's risk of developing severe symptoms. In some embodiments, the method may comprise measuring the amount of RNA transcripts encoded by at least two genes in a sample of RNA obtained from the subject, to obtain gene expression data; and based on the gene expression data, providing a report indicating the subject's risk of developing severe symptoms. Kits and methods of treatment are also provided.

Abstract: An automatic modeling method for a user-defined vehicle controller includes: configuring a component model; generating a description file; summarizing component input and output signals/parameters; and creating the user-defined vehicle controller. A template and data required by the user is provided to automatically build a vehicle controller port model, and a vehicle controller policy model framework to assist the user to quickly and flexibly build the vehicle controller model is provided. The problem of low efficiency in building various user-defined vehicle controller models for different vehicle types is solved. The user develops a vehicle controller policy model under the given model framework, and the model can run directly without additional configuration of port signals. The user can modify the vehicle controller policy model online in real time, which solves the problem that the application configuration of the vehicle controller is complex and cannot be updated online in real time.

Abstract: An automatic modeling method for a user-defined vehicle controller includes: configuring a component model; generating a description file; summarizing component input and output signals/parameters; and creating the user-defined vehicle controller. A template and data required by the user is provided to automatically build a vehicle controller port model, and a vehicle controller policy model framework to assist the user to quickly and flexibly build the vehicle controller model is provided. The problem of low efficiency in building various user-defined vehicle controller models for different vehicle types is solved. The user develops a vehicle controller policy model under the given model framework, and the model can run directly without additional configuration of port signals. The user can modify the vehicle controller policy model online in real time, which solves the problem that the application configuration of the vehicle controller is complex and cannot be updated online in real time.

Abstract: Replacement codons for modifying a genetic sequence are selected based on genetic architecture of a genome. For example, a location-specific estimation of codon usage can be generated, and preferred or un-preferred codons for a particular location can be identified statistically. A codon at a particular location can be replaced by a more-preferred or less-preferred synonymous codon. These techniques can be extended to replacement of k-mers of arbitrary length k within a segment of length s, where s is at least equal to k.

Abstract: The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.