Abstract: Provided herein are, inter alia, compounds inhibiting poly(ADP-ribose) Glycohydrolase (PARG) in a cancer cell and methods of treating cancer using compounds of the invention.

Abstract: The present disclosure provides a method and a kit for detecting cell-free DNA (cfDNA) methylation, and belongs to the technical field of early cancer screening. The method includes the following steps: constructing and mixing a cfDNA library and a filter DNA to obtain a mixture of the cfDNA library and the filter DNA, co-immunoprecipitating the mixture with anti-5-methylcytosine (5mC) antibody, conducting methylation capture on methylated DNA fragments in the mixture, and purifying and eluting to obtain a captured product fragment; conducting amplification and enrichment, purification, recovery and screening to obtain a sequencing library; and sequencing on an Illumina sequencing platform, and bioinformatically analyzing acquired experimental data to know about the cfDNA methylation.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: Provided herein, inter alia, are methods of treating cancer or cutaneous T-cell lymphoma (CTCL) using compounds of the invention.

Abstract: Described herein, inter alia, are IGF2BP2 inhibitor compounds and methods of using the same.

Abstract: Provided, inter alia, are methods and compositions for treating FTO-mediated cancer.

Abstract: The disclosure provides, inter alia, METTL16 inhibitors and methods of treating cancers that overexpress METTL16.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: Provided herein are, inter alia, compounds inhibiting poly(ADP-ribose) Glycohydrolase (PARG) in a cancer cell and methods of treating cancer using compounds of the invention.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: Disclosed are methods that create the perception for an audience that an actor is being transported from one location to another during a stage performance. Also disclosed are methods for entrance onto/exit from a stage platform by an actor, or entrance onto/exit from a stage backdrop by a precision image that represents an actor. The disclosed methods involve interaction of an actor with an object/prop or image of an object/prop, and/or involve interaction of an image of an actor with an object/prop or image of an object/prop during a stage performance.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: Disclosed are methods that create the perception for an audience that an actor is being transported from one location to another during a stage performance. Also disclosed are methods for entrance onto/exit from a stage platform by an actor, or entrance onto/exit from a stage backdrop by a precision image that represents an actor. The disclosed methods involve interaction of an actor with an object/prop or image of an object/prop, and/or involve interaction of an image of an actor with an object/prop or image of an object/prop during a stage performance.

Abstract: A system for aggregation and organization of multimedia data acquired from a plurality of sources can include a data collection element, a multimedia segmentation element, a memory, an extraction element, and a user interface. The data collection element can be configured to receive multimedia data. The multimedia segmentation element can be coupled to the data collection element and can be configured to separate the multimedia data into a plurality of multimedia data segments. The memory can be configured to store hierarchical category information having a plurality of categories. The extraction element can be coupled to the multimedia segmentation element and the memory and can be configured to associate at least one of the plurality of categories with each of the plurality of multimedia data segments.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: Disclosed herein, inter alia, are compositions and methods useful for treating liver diseases and metabolic diseases.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.

Abstract: A system for aggregation and organization of multimedia data acquired from a plurality of sources can include a data collection element, a multimedia segmentation element, a memory, an extraction element, and a user interface. The data collection element can be configured to receive multimedia data. The multimedia segmentation element can be coupled to the data collection element and can be configured to separate the multimedia data into a plurality of multimedia data segments. The memory can be configured to store hierarchical category information having a plurality of categories. The extraction element can be coupled to the multimedia segmentation element and the memory and can be configured to associate at least one of the plurality of categories with each of the plurality of multimedia data segments.