Abstract: A lipid delivery system, a virus-like structure (VLS) vaccine constructed therefrom, and a lipid particle capable of encapsulating an mRNA molecule encoding a SARS-CoV-2-specific antigen are provided. After the lipid particle encapsulates an mRNA molecule encoding a SARS-CoV-2 antigen, a SARS-CoV-2 S1 antigen protein can be embedded on a surface of an envelope structure of the lipid under specific buffer conditions to produce a VLS vaccine with an antigen-encoding mRNA molecule encapsulated inside and an outer membrane presenting a required viral antigen protein. The vaccine has a superior specific antibody-inducing ability to a SARS-CoV-2 mRNA vaccine and a polypeptide vaccine, can maintain a long-lasting high antibody level, and can also exhibit excellent immune binding abilities for the emerging different variants.

Abstract: A hydrophilic electrospinning biological composite scaffold material used for tissue regeneration and a preparation method and an application thereof are provided. Fibrinogen, L-arginine or an aqueous solution of hydrochloride thereof and a P(LLA-CL) solution are blended and an electrospinning technology is used to prepare the biological composite scaffold material. The biological composite scaffold material has an equilibrium contact angle that is less than 55°, is hydrophilic and has a good application prospect in repairing body tissue defects.

Abstract: A hydrophilic electrospinning biological composite stent material used for tissue regeneration and a preparation method and an application thereof are provided. An aqueous solution of Fibrinogen, L-arginine or hydrochloride thereof and a P(LLA-CL) solution are blended and an electrospinning technology is used to prepare the biological composite stent material. The biological composite stent material has an equilibrium contact angle that is less than 55°, is hydrophilic and has a good application prospect in repairing body tissue defects.