Abstract: The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments the errors are random.

Abstract: The present application relates to compositions for preventing or treating infections. In some embodiments, the present application provides chimeric proteins comprising a target-binding moiety comprising an extracellular binding domain (EBD) of an angiotensin-converting enzyme 2 (ACE2) protein or a fragment thereof that specifically binds to an S protein, and a positively charged mucoadhesive peptide fragment. Compositions comprising the chimeric proteins described herein are useful for preventing or treating a viral infection in an individual, such as a coronavirus infection.

Abstract: A multimedia cloud service method, a communication cloud system and a computer readable storage medium are disclosed. The method may include, receiving, by the signaling cloud system, a media service request; controlling, according to the media service request, by the signaling cloud system, the media control entity to process the media service rule; and establishing, according to the media service rule, by the media control entity, a media data interaction path between the terminal device and the media exchange entity.

Abstract: Provided are a surgical table and a supporting structure. The surgical table includes a supporting platform, a holding component, a supporting assembly, a releasing component, and a limiting component. The holding component is rotatably installed on the supporting platform in a vertical direction. The supporting assembly is provided at the bottom of the holding component, and includes a first installation end rotatably connected to the supporting platform and a second installation end movably connected to the holding component. A release button is provided at the second installation end of the supporting assembly, and the releasing component is movably connected to the second installation end When the holding component overturns relative to the supporting platform as the holding component is acted upon by a force, the limiting component drives the releasing component to move relative to the second installation end to trigger the release button.

Abstract: The present application provides chimeric proteins comprising an antibody moiety that specifically binds to a component of an influenza virus or a variant thereof, and a positively charged mucoadhesive peptide fragment. Compositions comprising the chimeric proteins described herein are useful for preventing or treating an infection caused by an influenza virus or a variant thereof in an individual.

Abstract: An in-situ detection robot and method for geological information without disturbance of in-situ stress, including a sleeve, a drilling unit set at the top of the sleeve, a dumping unit set inside the sleeve, and a support propulsion unit is set outside the sleeve, the top of the dumping unit extends into the drilling unit, a detection unit is set between the drilling unit and the support propulsion unit, and the robot tail is connected to a control unit; the dumping unit is used to discharge soil drilled from a hole of the drilling unit to the ground, the support propulsion unit is used to realize support, the detection unit is used to detect geological information of surrounding environment of the robot, the control unit is used to control the drilling unit, the support propulsion unit and the detection unit, and the control unit collects and processes the geological information.

Abstract: The present invention discloses an optimization method for natural gas pipeline operation under the carbon neutrality target. From the perspective of energy structure adjustment, the present invention proposes a complete low-carbon and low-consumption optimization model of long-distance natural gas transmission network, which is used for fine calculation of multi-energy carbon emissions and energy consumption in the transportation process of natural gas pipeline network; according to different energy structure backgrounds, the corresponding objective function for minimum carbon emissions is established, the optimization algorithm is adopted to solve the objective function for minimum carbon emissions and work out the optimal scheduling scheme.

Abstract: The present disclosure relates to the technical field of vehicle steering, and provides an electrically adjustable steering column and an electric power steering system.

Abstract: Described herein are immune cells comprising: a T-cell receptor (TCR) and a chimeric stimulating receptor (CSR) that comprises (i) a ligand-binding module that is capable of binding or interacting with a target ligand; (ii) a transmembrane domain; and (iii) a CD30 costimulatory domain, in which the CSR in the immune cells lacks a functional primary signaling domain. Also provided herein are methods of using the same or components thereof (e.g., the CSR) for therapeutic treatment of cancers (e.g., solid tumor cancers).

Abstract: The present disclosure relates to the technical field of vehicle steering, and provides an electrically adjustable steering column and an electric power steering system.

Abstract: The present application relates to compositions for preventing or treating viral and other microbial infections. In some embodiments, the present application provides chimeric proteins comprising a target-binding moiety that specifically binds to a pathogen that infects through a mucosa, and a positively charged mucoadhesive peptide fragment. Also provided are antibodies and constructs thereof that specifically binds to an S1 subunit of a spike protein of SARS-CoV-2. Compositions comprising the chimeric proteins, antibodies, or constructs described herein are useful for preventing or treating a microbial infection in an individual, such as a coronavirus infection.

Abstract: The present invention discloses an optimization method for natural gas pipeline operation under the carbon neutrality target. From the perspective of energy structure adjustment, the present invention proposes a complete low-carbon and low-consumption optimization model of long-distance natural gas transmission network, which is used for fine calculation of multi-energy carbon emissions and energy consumption in the transportation process of natural gas pipeline network; according to different energy structure backgrounds, the corresponding objective function for minimum carbon emissions is established, the optimization algorithm is adopted to solve the objective function for minimum carbon emissions and work out the optimal scheduling scheme.

Abstract: Provided herein are components (e.g., cells and soluble proteins), systems, and methods for assessing the biological activity of soluble proteins comprising an Fc domain and a CD28-binding domain (e.g., CD80 extracellular domain Fc fusion proteins).

Abstract: Described herein are immune cells comprising: a chimeric antigen receptor (CAR) that comprises (i) an extracellular target-binding domain comprising an antibody moiety; (ii) a transmembrane domain; and (iii) a primary signaling domain, and a chimeric stimulating receptor (CSR) that comprises (i) a ligand-binding module that is capable of binding or interacting with a target ligand; (ii) a transmembrane domain; and (iii) a CD30 costimulatory domain, in which the CSR in the immune cells lacks a functional primary signaling domain. Also provided herein are methods of using the same or compositions thereof for therapeutic treatment of cancers (e.g., hematological cancers or solid tumor cancers).