Patents by Inventor Hongchuan Yu

Hongchuan Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMIC DELIVERY OF OLIGONUCLEOTIDES
    Publication number: 20230277675
    Abstract: The disclosure provides oligonucleotide-ligand conjugates to facilitate the systemic delivery of oligonucleotides designed to prevent, limit or modulate the expression of mRNA molecules. The conjugates comprise nucleotides which are linked to lipid conjugate moieties or adamantyl groups.
    Type: Application
    Filed: July 21, 2021
    Publication date: September 7, 2023
    Inventors: Weimin WANG, Bob Dale BROWN, Hongchuan YU, Xiaochuan CAI, Marc ABRAMS
  • In vitro and in vivo intracellular delivery of siRNA via self-assembled nanopieces
    Patent number: 11701379
    Abstract: The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: July 18, 2023
    Assignee: Rhode Island Hospital
    Inventors: Qian Chen, Yupeng Chen, Hongchuan Yu
  • NANOMATERIAL COMPOSITIONS, SYNTHESIS, AND ASSEMBLY
    Publication number: 20230183253
    Abstract: Compositions or an assembly of a series of biomimetic compounds include chemical structures that mimic or structurally resemble a nucleic acid base pair. Complexes of nanotubes and agents are useful to deliver agents into the cells or bodily tissues of individuals for therapeutic and diagnostic purposes. Exemplary compounds include those of Formula (I), (III), (V) or (VII), or of Formula (II), (IV), (VI) or (VIII).
    Type: Application
    Filed: January 18, 2023
    Publication date: June 15, 2023
    Inventors: Qian CHEN, Hongchuan YU, Yupeng CHEN
  • 4'-O-METHYLENE PHOSPHONATE NUCLEIC ACIDS AND ANALOGUES THEREOF
    Publication number: 20230123981
    Abstract: The present invention relates to nucleic acids and analogues thereof useful as potent and stable RNA interference agents.
    Type: Application
    Filed: January 15, 2021
    Publication date: April 20, 2023
    Inventors: Weimin WANG, Hongchuan YU
  • Nanomaterial compositions, synthesis, and assembly
    Patent number: 11608340
    Abstract: Compositions or an assembly of a series of biomimetic compounds include chemical structures that mimic or structurally resemble a nucleic acid base pair. Complexes of nanotubes and agents are useful to deliver agents into the cells or bodily tissues of individuals for therapeutic and diagnostic purposes. Exemplary compounds include those of Formula (I), (III), (V) or (VII), or of Formula (II), (IV), (VI) or (VIII).
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: March 21, 2023
    Assignee: Rhode Island Hospital
    Inventors: Qian Chen, Hongchuan Yu, Yupeng Chen
  • IN VITRO AND IN VIVO INTRACELLULAR DELIVERY OF SIRNA VIA SELF-ASSEMBLED NANOPIECES
    Publication number: 20210023117
    Abstract: The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
    Type: Application
    Filed: March 26, 2019
    Publication date: January 28, 2021
    Inventors: Qian Chen, Yupeng Chen, Hongchuan Yu
  • NANOCARRIERS AND THEIR PROCESSING FOR DIAGNOSTICS AND THERAPEUTICS
    Publication number: 20200375991
    Abstract: The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
    Type: Application
    Filed: January 10, 2020
    Publication date: December 3, 2020
    Inventors: Qian Chen, Yupeng Chen, Hongchuan Yu, Michael G. Ehrlich
  • Nanocarriers and their processing for diagnostics and therapeutics
    Patent number: 10555948
    Abstract: The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: February 11, 2020
    Assignee: Rhode Island Hospital
    Inventors: Qian Chen, Yupeng Chen, Hongchuan Yu, Michael G. Ehrlich
  • Nanocarriers And Their Processing For Diagnostics And Therapeutics
    Publication number: 20180193344
    Abstract: The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
    Type: Application
    Filed: August 25, 2017
    Publication date: July 12, 2018
    Inventors: Qian Chen, Yupeng Chen, Hongchuan Yu, Michael G. Ehrlich
  • NANOMATERIAL COMPOSITIONS, SYNTHESIS, AND ASSEMBLY
    Publication number: 20170362238
    Abstract: Compositions or an assembly of a series of biomimetic compounds include chemical structures that mimic or structurally resemble a nucleic acid base pair. Complexes of nanotubes and agents are useful to deliver agents into the cells or bodily tissues of individuals for therapeutic and diagnostic purposes. Exemplary compounds include those of Formula (I), (III), (V) or (VII), or of Formula (II), (IV), (VI) or (VIII).
    Type: Application
    Filed: November 17, 2015
    Publication date: December 21, 2017
    Inventors: Qian CHEN, Hongchuan YU, Yupeng CHEN
  • Nanocarriers and their processing for diagnostics and therapeutics
    Patent number: 9775842
    Abstract: The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: October 3, 2017
    Assignee: Rhode Island Hospital
    Inventors: Qian Chen, Yupeng Chen, Hongchuan Yu, Michael G. Ehrlich
  • Nanocarriers And Their Processing For Diagnostics And Therapeutics
    Publication number: 20150258094
    Abstract: The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
    Type: Application
    Filed: March 16, 2015
    Publication date: September 17, 2015
    Inventors: Qian Chen, Yupeng Chen, Hongchuan Yu, Michael G. Ehrlich