Patents by Inventor Hongfan Jin

Hongfan Jin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fusion partners for peptide production
    Patent number: 10981968
    Abstract: The present invention relates to the field of medicine, in particular, to the production of large amounts of a soluble recombinant polypeptide as part of a fusion protein comprising an N-terminal fusion partner linked to the polypeptide of interest.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: April 20, 2021
    Assignee: Pfenex Inc.
    Inventors: Diane M. Retallack, Adam Chapman, Torben R. Bruck, Hongfan Jin
  • FUSION PARTNERS FOR PEPTIDE PRODUCTION
    Publication number: 20190135889
    Abstract: The present invention relates to the field of medicine, in particular, to the production of large amounts of a soluble recombinant polypeptide as part of a fusion protein comprising an N-terminal fusion partner linked to the polypeptide of interest.
    Type: Application
    Filed: September 19, 2018
    Publication date: May 9, 2019
    Inventors: Diane M. RETALLACK, Adam CHAPMAN, Torben R. BRUCK, Hongfan JIN
  • Fusion partners for peptide production
    Patent number: 10118956
    Abstract: The present invention relates to the field of medicine, in particular, to the production of large amounts of a soluble recombinant polypeptide as part of a fusion protein comprising an N-terminal fusion partner linked to the polypeptide of interest.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: November 6, 2018
    Assignee: PFENEX INC.
    Inventors: Diane M. Retallack, Adam Chapman, Torben R. Bruck, Hongfan Jin
  • FUSION PARTNERS FOR PEPTIDE PRODUCTION
    Publication number: 20160159877
    Abstract: The present invention relates to the field of medicine, in particular, to the production of large amounts of a soluble recombinant polypeptide as part of a fusion protein comprising an N-terminal fusion partner linked to the polypeptide of interest.
    Type: Application
    Filed: November 30, 2015
    Publication date: June 9, 2016
    Inventors: Diane M. Retallack, Adam Chapman, Torben R. Bruck, Hongfan Jin
  • Process for improved protein expression by strain engineering
    Patent number: 9109229
    Abstract: This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: August 18, 2015
    Assignee: Pfenex Inc.
    Inventors: Thomas M. Ramseier, Hongfan Jin, Charles H. Squires
  • PROCESS FOR IMPROVED PROTEIN EXPRESSION BY STRAIN ENGINEERING
    Publication number: 20140162279
    Abstract: This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein.
    Type: Application
    Filed: November 4, 2013
    Publication date: June 12, 2014
    Applicant: PFENEX INC.
    Inventors: THOMAS M. RAMSEIER, HONGFAN JIN, CHARLES H. SQUIRES
  • Process for improved protein expression by strain engineering
    Patent number: 8603824
    Abstract: This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: December 10, 2013
    Assignee: Pfenex, Inc.
    Inventors: Thomas M. Ramseier, Hongfan Jin, Charles H. Squires
  • High level expression of recombinant toxin proteins
    Patent number: 8530171
    Abstract: The present invention relates to the field of recombinant toxin protein production in bacterial hosts. In particular, the present invention relates to production processes for obtaining high levels of a recombinant CRM197, Diphtheria Toxin, Pertussis Toxin, Tetanus Toxoid Fragment C, Cholera Toxin B, Cholera holotoxin, and Pseudomonas Exotoxin A, from a bacterial host.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: September 10, 2013
    Assignee: Pfenex Inc.
    Inventors: Diane M. Retallack, Lawrence Chew, Hongfan Jin, Henry W. Talbot
  • Methods for G-CSF production in a host cell
    Patent number: 8455218
    Abstract: The present invention relates to the field of recombinant protein production in bacterial hosts. It further relates to expression of soluble, active recombinant protein by using secretion signals to direct the protein to the periplasmic space of a bacterial cell. In particular, the present invention relates to a production process for obtaining soluble hG-CSF protein from a bacterial host.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: June 4, 2013
    Assignee: Pfenex, Inc.
    Inventors: Hongfan Jin, Lawrence Chew
  • HIGH LEVEL EXPRESSION OF RECOMBINANT TOXIN PROTEINS
    Publication number: 20110287443
    Abstract: The present invention relates to the field of recombinant toxin protein production in bacterial hosts. In particular, the present invention relates to production processes for obtaining high levels of a recombinant CRM197, Diphtheria Toxin, Pertussis Toxin, Tetanus Toxoid Fragment C, Cholera Toxin B, Cholera holotoxin, and Pseudomonas Exotoxin A, from a bacterial host.
    Type: Application
    Filed: March 28, 2011
    Publication date: November 24, 2011
    Applicant: Pfenex Inc.
    Inventors: Diane M. Retallack, Lawrence Chew, Hongfan Jin, Henry W. Talbot
  • METHODS FOR G-CSF PRODUCTION IN A PSEUDOMONAS HOST CELL
    Publication number: 20110245474
    Abstract: The present invention relates to the field of recombinant protein production in bacterial hosts. It further relates to expression of soluble, active recombinant protein by using secretion signals to direct the protein to the periplasmic space of a bacterial cell. In particular, the present invention relates to a production process for obtaining soluble hG-CSF protein from a bacterial host.
    Type: Application
    Filed: March 30, 2011
    Publication date: October 6, 2011
    Applicant: Pfenex Inc.
    Inventors: Hongfan Jin, Lawrence Chew
  • Process for improved protein expression by strain engineering
    Publication number: 20060110747
    Abstract: This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein.
    Type: Application
    Filed: July 26, 2005
    Publication date: May 25, 2006
    Applicant: Dow Global Technologies Inc.
    Inventors: Thomas Ramseier, Hongfan Jin, Charles Squires