Patents by Inventor Hongfeng Deng

Hongfeng Deng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CANNABINOIDS AND USES THEREOF
    Publication number: 20210284621
    Abstract: The invention relates to cannabinoid compounds, pharmaceutical compositions including one or more cannabinoid compounds, and the use of pharmaceutical compositions including one or more cannabinoid compounds for the treatment of a disease or condition (e.g., a fibrotic disease or an inflammatory disease) in a subject in need thereof.
    Type: Application
    Filed: May 31, 2019
    Publication date: September 16, 2021
    Inventors: Kristos Adrian MOSHOS, Clifton D. LEIGH, Yuhua George ZHANG, Mark TEPPER, Hongfeng DENG
  • Modulators of indoleamine 2,3-dioxygenase
    Patent number: 10906924
    Abstract: Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: February 2, 2021
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Martha Alicia De La Rosa, Hongfeng Deng, Ghotas Evindar, Wieslaw Mieczyslaw Kazmierski, John Franklin Miller, Vicente Samano, Yoshiaki Washio, Bing Xia
  • MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE
    Publication number: 20200165280
    Abstract: Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases.
    Type: Application
    Filed: June 27, 2018
    Publication date: May 28, 2020
    Inventors: Martha Alicia DE LA ROSA, Hongfeng DENG, Ghotas EVINDAR, Wieslaw Mieczyslaw KAZMIERSKI, John Franklin MILLER, Vicente SAMANO, Yoshiaki WASHIO, Bing XIA
  • S1P-1 RECEPTOR AGONISTS
    Publication number: 20110039933
    Abstract: The invention provides compounds formula (I), their preparation, and their use as pharmaceutically active immuno-suppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SIP receptors.
    Type: Application
    Filed: August 7, 2007
    Publication date: February 17, 2011
    Applicant: PRAECIS PHARMACEUTICALS INCORPORATION
    Inventors: Ghotas Evindar, Hongfeng Deng
  • Receptor selective cannabimimetic aminoalkylindoles
    Patent number: 7820144
    Abstract: Disclosed are cannabimimetic aminoalkylindole compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. The disclosed compounds may include radioactive atoms. Also disclosed are methods of using the disclosed compounds, including use of the disclosed compounds to stimulate a cannabinoid receptor, to provide a physiological effect in an animal or individual, to treat a condition in an animal or individual and for use in radioimaging.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: October 26, 2010
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Hongfeng Deng
  • Sphingosine-1-phosphate (SIP) receptor agonists
    Patent number: 7759370
    Abstract: The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or S1P receptors.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: July 20, 2010
    Assignee: Praecis Pharmaceuticals
    Inventors: Ghotas Evindar, Hongfeng Deng, Sylvie Bernier, Gang Yao, Aaron Coffin, Hongfang Yang
  • SUBSTITUTED AZETIDINONES
    Publication number: 20100144698
    Abstract: Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd? are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
    Type: Application
    Filed: February 10, 2010
    Publication date: June 10, 2010
    Applicant: DAIAMED
    Inventors: Thomas Bannister, Cassandra Celatka, Nizal S. Chandrakumar, Hongfeng Deng, Zihong Guo, Lei Jin, Tsveltelina Lazarova, Jian Lin, Scott T. Moe, Pamela Nagafuji, Manuel Navia, Amy Ripka, Michael J. Rynkiewicz, Kerry L. Spear, James E. Stickler, Roger Xie
  • AGONISTS OF SPHINGOSINE-1 PHOSPHATE RECEPTOR (SLP)
    Publication number: 20100016260
    Abstract: The invention provides compounds of formula I and formula II, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SIP receptors.
    Type: Application
    Filed: August 1, 2007
    Publication date: January 21, 2010
    Applicant: PRAECIS PHARMACEUTICALS INCORPORATED
    Inventors: Hongfeng Deng, Ghotas Evindar, Sylvie Bernier, Gang Yao, Aaron Coffin, Hongfang Yang, Raksha A. Acharya
  • CHEMICAL COMPOUNDS
    Publication number: 20100009936
    Abstract: The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immuno-suppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SIP receptors.
    Type: Application
    Filed: August 1, 2007
    Publication date: January 14, 2010
    Applicant: PRAECIS PHARMACEUTICALS INCORPORATED
    Inventors: Ghotas Evindar, Hongfeng Deng, Sylvie Bernier, Gang Yao, Aaron Coffin, Hongfang Yang
  • AGONISTS OF THE SPHINGOSINE-1 PHOSPHATE RECEPTOR
    Publication number: 20090318389
    Abstract: The invention provides compounds formulae I-III, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or SIP receptors.
    Type: Application
    Filed: August 2, 2007
    Publication date: December 24, 2009
    Applicant: PRAECIS PHARMACEUTICALS INCORPORATED
    Inventors: Ghotas Evindar, Hongfeng Deng
  • SUBSTITUTED AZETIDINONES
    Publication number: 20090143351
    Abstract: Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd? are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
    Type: Application
    Filed: January 26, 2009
    Publication date: June 4, 2009
    Applicant: DAIAMED
    Inventors: Thomas Bannister, Cassandra Celatka, Nizal S. Chandrakumar, Hongfeng Deng, Zihong Guo, Lei Jin, Tsvetelina Lazarova, Jian Lin, Scott T. Moe, Pamela Nagafuji, Manuel Navia, Amy Ripka, Michael J. Rynkiewicz, Kerry L. Spear, James E. Stickler, Roger Xie
  • Substituted azetidinones
    Patent number: 7501404
    Abstract: Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd? are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: March 10, 2009
    Assignee: DAIMED
    Inventors: Thomas Bannister, Cassandra Celatka, Nizal S. Chandrakumar, Hongfeng Deng, Zihong Guo, Lei Jin, Tsvetelina Lazarova, Jian Lin, Scott T. Moe, Pamela Nagafuji, Manuel Navia, Amy Ripka, Michael J. Rynkiewicz, Kerry L. Spear, James E. Stickler, Roger Xie
  • Compounds and Methods For Treatment of Thrombosis
    Publication number: 20080146811
    Abstract: The invention provides compounds, pharmaceutical compositions, and methods for the treatment of thromboembolic disorders, such as, for example, arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, or thromboembolic disorders in the chambers of the heart.
    Type: Application
    Filed: July 22, 2005
    Publication date: June 19, 2008
    Inventors: Hongfeng Deng, Jian Lin, Zihong Guo, Harold V. Meyers, Sherin S. Abdel-Meguid, Robert E. Babine
  • Chemical compounds
    Publication number: 20080096938
    Abstract: The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or S1P receptors.
    Type: Application
    Filed: August 1, 2007
    Publication date: April 24, 2008
    Applicant: Praecis Pharmaceuticals Incorporated
    Inventors: Ghotas Evindar, Hongfeng Deng, Sylvie Bernier, Gang Yao, Aaron Coffin, Hongfang Yang
  • CANNABIMIMETIC INDOLE DERIVATIVES
    Publication number: 20080090871
    Abstract: Novel cannabimimetic indole derivatives are presented which have preferentially high affinities for one of the cannabinoid CB1 or CB2 receptors. The improved receptor affinity makes these analogs therapeutically useful as medications in individuals and animals for treatment of pain, glaucoma, epilepsy, nausea associated with chemotherapy.
    Type: Application
    Filed: July 10, 2007
    Publication date: April 17, 2008
    Inventors: Alexandros Makriyannis, Hongfeng Deng
  • Chemical compounds
    Publication number: 20080070866
    Abstract: The invention provides compounds of formula I and formula II, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as other disorders modulated by lymphopenia or S1P receptors.
    Type: Application
    Filed: August 1, 2007
    Publication date: March 20, 2008
    Applicant: Praecis Pharmaceuticals Incorporated
    Inventors: Hongfeng Deng, Ghotas Evindar, Sylvie Bernier, Gang Yao, Aaron Coffin, Hongfang Yang, Raksha Acharya
  • Cannabimimetic ligands
    Patent number: 7329651
    Abstract: Disclosed are heterocyclic compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. Also disclosed are methods of using the disclosed compounds, including use of the disclosed compounds to stimulate a cannabinoid receptor, to provide a physiological effect in an animal or individual and to treat a condition in an animal or individual.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: February 12, 2008
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Hongfeng Deng
  • Receptor Selective Cannabimimetic Aminoalkylindoles
    Publication number: 20070243134
    Abstract: Disclosed are cannabimimetic aminoalkylindole compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. The disclosed compounds may include radioactive atoms. Also disclosed are methods of using the disclosed compounds, including use of the disclosed compounds to stimulate a cannabinoid receptor, to provide a physiological effect in an animal or individual, to treat a condition in an animal or individual and for use in radioimaging.
    Type: Application
    Filed: January 5, 2007
    Publication date: October 18, 2007
    Inventors: Alexandros Makriyannis, Hongfeng Deng
  • Cannabimimetic indole derivatives
    Patent number: 7241799
    Abstract: Cannabimimetic indole derivatives are presented which have preferentially high affinities for one of the cannabinoid CB1 or CB2 receptor sites. The improved receptor affinity makes these analogs therapeutically useful as medications in individuals and animals.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: July 10, 2007
    Assignee: University of Connecticut
    Inventors: Alexandros Makriyannis, Hongfeng Deng
  • Compounds and methods for treatment of thrombosis
    Patent number: 7217794
    Abstract: The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention also provides three-dimensional structures of Factor XIa and methods for designing or selecting additional Factor XIa inhibitors using these structures.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: May 15, 2007
    Assignee: Daiamed, Inc.
    Inventors: Sherin S. Abdel-Meguid, Robert E. Babine, Hongfeng Deng, Lei Jin, Jian Lin, Scott R. Magee, Harold V. Meyers, Pramod Pandey, Michael J. Rynkiewicz, David T. Weaver, Zihong Gho, Thomas D. Bannister