Patents by Inventor Honghua Zhang

Honghua Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250059586
    Abstract: Disclosed herein include methods, compositions, and kits for use in detecting a target nucleic acid sequence in a sample. Provided include storage-stable lysis buffers. In some embodiments, the lysis buffer comprises: one or more surfactants and magnesium sulfate (MgSO4). In some embodiments, the formation of a precipitate (for example, a complex of Mg+2 and the one or more surfactants) is substantially inhibited for a period of time under at least one storage condition.
    Type: Application
    Filed: February 3, 2023
    Publication date: February 20, 2025
    Inventors: James Petisce, Chang Chen, Meghan Elizabeth Wolfgang, Honghua Zhang, Tanya Ferguson, James Nealis
  • Publication number: 20250059612
    Abstract: Disclosed herein include methods, compositions, and kits for use in detecting a target nucleic acid sequence in a sample. Provided include acidic compositions for separating dsDNA. In some embodiments, the acidic compositions comprise a monovalent salt and/or a divalent salt, one or more surfactants, and an acidic agent. In some embodiments, the pH of the acidic composition is less than 4. Also provided herein are reagent compositions comprising a buffering agent and one or more amplification agents.
    Type: Application
    Filed: February 3, 2023
    Publication date: February 20, 2025
    Inventors: Honghua Zhang, Daniel Jacob Koslover
  • Publication number: 20250051837
    Abstract: Disclosed herein include methods, kits, and reaction mixtures suitable for use in monitoring an amplification reaction. Some embodiments provide a first and a second quality control primer capable of hybridizing to each other and each comprising a quenchable label or a quencher.
    Type: Application
    Filed: February 13, 2023
    Publication date: February 13, 2025
    Inventors: Gregory A. Richart, Sydney Bryce Tola, Ejan Marie Tyler, Honghua Zhang
  • Publication number: 20240209426
    Abstract: The technology relates in part to methods and compositions for isothermal amplification of nucleic acids.
    Type: Application
    Filed: December 14, 2023
    Publication date: June 27, 2024
    Inventors: Andrew P. Miller, Honghua Zhang
  • Patent number: 11884969
    Abstract: The technology relates in part to methods and compositions for isothermal amplification of nucleic acids.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: January 30, 2024
    Assignee: NAT DIAGNOSTICS, INC.
    Inventors: Andrew P. Miller, Honghua Zhang
  • Publication number: 20240028937
    Abstract: A method for evaluating the health status of a petrochemical atmospheric oil storage tank using data from multiple sources. The health status of an atmospheric oil storage tank is influenced by multiple factors, and is evaluated by: acquiring corresponding sensor data and comprehensively considering the sensor data along with basic data of the oil storage tank, and selecting from a dynamic monitoring parameter-based health status and a basic health status of the oil storage tank, the one having a greater severity level, so as to determine the final health status of the oil storage tank. The method is used to conduct a comprehensive scientific assessment of the health status of an oil storage tank, and improves the use safety of the oil storage tank.
    Type: Application
    Filed: March 12, 2021
    Publication date: January 25, 2024
    Inventors: Honghua Zhang, Qinda Zeng, Yuanyue Zeng, Gengfeng Zheng, Chunrong Huang, Yao Lin, Ning Lin, Ting Xiao
  • Patent number: 11634770
    Abstract: This invention relates to methods and compositions for detecting the presence or absence of a Respiratory Syncytial Virus target nucleic acid in a biological sample using isothermal nucleic acid amplification.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: April 25, 2023
    Assignee: IONIAN TECHNOLOGIES, LLC
    Inventors: Honghua Zhang, Richard Roth
  • Publication number: 20220251629
    Abstract: The technology relates in part to methods and compositions for isothermal amplification of nucleic acids.
    Type: Application
    Filed: March 15, 2022
    Publication date: August 11, 2022
    Inventors: Andrew P. Miller, Honghua Zhang
  • Patent number: 11299777
    Abstract: The technology relates in part to methods and compositions for isothermal amplification of nucleic acids.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: April 12, 2022
    Assignee: Nat Diagnostics, Inc.
    Inventors: Andrew P. Miller, Honghua Zhang
  • Publication number: 20220098652
    Abstract: This invention relates to compositions, methods and kits for detecting the presence or absence of a bacterial species in a biological sample using isothermal nucleic acid amplification.
    Type: Application
    Filed: October 26, 2021
    Publication date: March 31, 2022
    Inventors: Daiwei Shen, Richard Roth, Honghua Zhang
  • Publication number: 20220064703
    Abstract: The technology relates in part to methods and compositions for isothermal amplification of nucleic acids.
    Type: Application
    Filed: August 13, 2021
    Publication date: March 3, 2022
    Inventors: Andrew P. Miller, Honghua Zhang
  • Patent number: 11186864
    Abstract: This invention relates to compositions, methods and kits for detecting the presence or absence of a bacterial species in a biological sample using isothermal nucleic acid amplification.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: November 30, 2021
    Assignee: IONIAN TECHNOLOGIES, LLC
    Inventors: Daiwei Shen, Richard Roth, Honghua Zhang
  • Patent number: 11118219
    Abstract: The technology relates in part to methods and compositions for isothermal amplification of nucleic acids.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: September 14, 2021
    Assignee: Nat Diagnostics, Inc.
    Inventors: Andrew P. Miller, Honghua Zhang
  • Publication number: 20210155965
    Abstract: A method includes combining a polynucleotide and an amplification reagent mixture to form a reaction mixture, wherein the reaction mixture comprises reversibly bound divalent ions in solution, and adjusting the pH of the reaction mixture to release the reversibly bound divalent ions, thereby initiating amplification of the polynucleotide.
    Type: Application
    Filed: December 3, 2020
    Publication date: May 27, 2021
    Inventors: Honghua Zhang, Jarrod Provins, Richard Roth
  • Patent number: 10927393
    Abstract: A method includes combining a polynucleotide and an amplification reagent mixture to form a reaction mixture, wherein the reaction mixture comprises reversibly bound divalent ions in solution, and adjusting the pH of the reaction mixture to release the reversibly bound divalent ions, thereby initiating amplification of the polynucleotide.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: February 23, 2021
    Assignee: Ionian Technologies, LLC
    Inventors: Honghua Zhang, Jarrod Provins, Richard Roth
  • Publication number: 20200332340
    Abstract: The technology relates in part to methods and compositions for isothermal amplification of nucleic acids.
    Type: Application
    Filed: May 13, 2020
    Publication date: October 22, 2020
    Inventors: Andrew P. Miller, Honghua Zhang
  • Publication number: 20200255885
    Abstract: The technology relates in part to methods and compositions for isothermal amplification of nucleic acids.
    Type: Application
    Filed: March 6, 2017
    Publication date: August 13, 2020
    Inventors: Andrew P. MILLER, Honghua ZHANG
  • Patent number: D1005052
    Type: Grant
    Filed: January 17, 2023
    Date of Patent: November 21, 2023
    Inventor: Honghua Zhang
  • Patent number: D1005807
    Type: Grant
    Filed: May 29, 2023
    Date of Patent: November 28, 2023
    Assignee: Shenzhen Jingsheng Technology Co., Ltd.
    Inventor: Honghua Zhang
  • Patent number: D1028632
    Type: Grant
    Filed: December 14, 2023
    Date of Patent: May 28, 2024
    Assignee: Shenzhen Jingsheng Technology Co., Ltd.
    Inventor: Honghua Zhang