Abstract: This application relates to novel substituted bicyclic aza-heterocycles and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with mammalian RAS (Rat sarcoma virus) family proteins.

Abstract: This application relates to novel heterotricyclic compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with mammalian RAS (Rat sarcoma virus) family proteins.

Abstract: A low shearing curved surface granulator for bulk feed consists of a feeding mechanism and a granulating mechanism; wherein the mainbody of the feeding mechanism is a cylindrical body, the main part of the granulating mechanism is a groove pipe with flanges on both its ends, the groove pipe is longitudinally mounted on the cylindrical body, and the granulator is provided with a ball comber board and a ball scraper. A sector plate is mounted parallel to the cylindrical body on the inner cavity baseplane of the cylindrical body in the feeding mechanism; a driving wheel is set up under the sector plate; a sliding pin is fastened in the driving wheel; the sliding pin fits in with a slide way opened on the sector plate, which slides up and down in the slide way following rotating of the driving wheel, and the sector plate is made to swing repeatedly around the pin in the cylindrical body. The granulator performs massive feeding in one time, can greatly reduce labor.