Abstract: Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefore, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.

Abstract: Disclosed are a device and a method for producing high-pressure or super high-pressure steam as a byproduct from a maleic anhydride producing device. The device includes a super high-pressure steam drum, a molten salt pump, an oxidation reactor, a regulating valve, molten salt coolers, a switching cooler and a gas cooler. The molten salt pump, the oxidation reactor, the regulating valve and the molten salt coolers are connected. A boiler water buffer device and a boiler water booster pump are arranged between the switching cooler and the gas cooler. The unique design of the boiler water intermediate pressure boosting and the gas cooler in the disclosure makes the gas cooler and the switching cooler very easy to manufacture. Heat can be effectively recovered from process gas to produce high-pressure or super high-pressure steam while accumulation of dust in the process gas is avoided and tar adhesion is easy to clean.

Abstract: Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.

Abstract: A drug combination containing a TLR7 agonist. Specifically, a drug combination jointly using the compound of formula I acting as a TLR7 agonist and entecavir for the treatment of hepatitis B virus infection and a use thereof, the drug combination having a good anti-hepatitis B virus infection effect.

Abstract: A storage apparatus includes an over-provisioning (OP) reporting module and a cache management module. A storage method includes: The OP reporting module reports information about first OP to the cache management module, where the first OP is unoccupied OP obtained from OP of a flash storage device, and the OP reporting module and the cache management module are located respectively at a device layer and a kernel layer of the storage apparatus; and the cache management module configures a cache area based on the information about the first OP, where the cache area includes the first OP. According to the method, the management module at the kernel layer can configure redundant over-provisioning at the device layer, and the redundant over-provisioning can be used for caching user data.

Abstract: Disclosed is a methyl- and trifluoromethyl-containing disubstituted sulfonamide selective BCL-2 inhibitor; specifically disclosed are a compound of formula I, a stereoisomer or pharmaceutically acceptable salt of same, a preparation method therefor, and a pharmaceutical composition comprising the compound. Also disclosed are uses of the compound and of the pharmaceutical composition comprising the compound in treating anti-apoptotic protein BCL-2-related diseases such as cancer.

Abstract: A swimming pool frame includes a plurality of side members connected together to form a frame bounding an interior area, a plurality of leg members, and a plurality of joints. Each joint is connected between two adjacent side members, and a leg member is connected to each joint. Each of the side members and leg members have a non-circular cross-sectional profile that include shapes such as polygonal or elliptical shapes, and each joint includes similarly-shaped side member insertion channels and a leg member insertion channel. Each end of each side member is adapted to be inserted into a side member insertion channel of the joint, and an upper end of each leg member is adapted to be inserted into the leg member insertion channel. A retention pin is connected between each side member insertion channel and a corresponding side member.

Abstract: Provided is a compound of formula I or II, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and the medical uses thereof in treating diseases benefiting from the capsid protein assembly inhibitor, particularly diseases caused by hepatitis B virus infection.

Abstract: The present disclosure relates to methods and apparatus for compute processing. For example, disclosed techniques facilitate improving performance of matrix multiplication in streaming processor. Aspects of the present disclosure can execute, with a load control unit, a first load instruction to load a set of input data of an input matrix from a first memory to a second memory. Aspects of the present disclosure can also execute, with the load control unit, a second load instruction to load a set of weight data of a weight matrix from the first memory to the second memory. Additionally, aspects of the present disclosure can perform, with an ALU component, a matrix multiplication operation using the set of input data and the set of weight data to generate an output matrix. Further, aspects of the present disclosure can store the output matrix at a general purpose register accessible to the ALU component.

Abstract: The present disclosure relates to the technical field of antennas, and discloses a control method, a control component and a control device.

Abstract: The present disclosure relates to a compound containing cycloalkyl or haloalkyl, and specifically discloses a compound represented by formula I?, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and a use thereof in treating tumors.

Abstract: A direct current contactor includes a case and two groups of contact components disposed in the case. Each group of contact components includes two moving contacts connected to each other and two fixed contacts. The direct current contactor further includes a drive system configured to drive the moving contacts to move in a direction close to or away from the fixed contacts, so that the moving contacts are connected to or disconnected from the fixed contacts. The case has an arc-extinguishing cavity. A first baffle in the arc-extinguishing cavity divides the arc-extinguishing cavity into a first arc-extinguishing chamber and a second arc-extinguishing chamber. The contact components are respectively located in the first arc-extinguishing chamber and the second arc-extinguishing chamber. In other words, the two groups of contact components are integrated into two arc-extinguishing chambers of one arc-extinguishing cavity and perform connection/disconnection drive by using a single drive system.

Abstract: Disclosed are a compound of formula I as a toll-like receptor 7 (TLR7) agonist or a pharmaceutically acceptable salt thereof for treating colorectal cancer, a pharmaceutical combination for treating colorectal cancer comprising the TLR7 agonist and a tyrosine kinase inhibitor, and the use of the compound of formula I or the pharmaceutically acceptable salt thereof and the pharmaceutical combination for treating colorectal cancer.

Abstract: A pyridyl-containing compound represented by formula I and a preparation method therefor, and the use thereof in the preparation for a drug for treating tumors.

Abstract: Disclosed are a device and a method for producing high-pressure or super high-pressure steam as a byproduct from a maleic anhydride producing device. The device includes a super high-pressure steam drum, a molten salt pump, an oxidation reactor, a regulating valve, molten salt coolers, a switching cooler and a gas cooler. The molten salt pump, the oxidation reactor, the regulating valve and the molten salt coolers are connected. A boiler water buffer device and a boiler water booster pump are arranged between the switching cooler and the gas cooler. The unique design of the boiler water intermediate pressure boosting and the gas cooler in the disclosure makes the gas cooler and the switching cooler very easy to manufacture. Heat can be effectively recovered from process gas to produce high-pressure or super high-pressure steam while accumulation of dust in the process gas is avoided and tar adhesion is easy to clean.

Abstract: A vent assembly for a respiratory therapy system configured in use to convey a vent flow of gases exhaled by a patient from a first volume interior to the respiratory therapy system to ambient. The vent assembly comprises a vent base, a flexible membrane and a vent cap. The membrane being mounted to the vent base and spanning across a vent base aperture. The vent cap is also mounted to the vent base and is located downstream of the membrane relative to the vent flow. The vent cap being positioned in the path of the vent flow through a membrane aperture. In use, the pressure of gas in the first volume acts on the membrane causing the membrane to flex thereby varying a position of the membrane relative to the vent cap in order to control the vent flow.

Abstract: Provided are an anti-CD40 antibody and a use thereof, such as a mouse, human, chimeric, or humanized antibody specifically binding to CD40, and an antigen-binding fragment thereof, and further provided are a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, and an expression vector and a host cell for expressing the antibody or the antigen-binding fragment thereof. Further provided are a preparation method and a use method for the antibody or the antigen-binding fragment thereof, comprising treating and preventing immune diseases.

Abstract: A patient interface comprising a plenum chamber, a seal-forming structure configured to form a seal with a region of the patient's face surrounding an entrance to the patient's airways, and a vent structure configured to allow a flow of gases exhaled by the patient from an interior of the plenum chamber to ambient. The plenum chamber comprises an anterior portion comprising an inlet configured to receive a flow of air at the therapeutic pressure for breathing by the patient. The vent structure is configured to vent the flow of gases from the interior of the plenum chamber in a substantially lateral direction in use. The patient interface further comprises a deflector configured to redirect the laterally vented flow of gases. The patient interface further comprises a diffuser to diffuse the vented flow of gases.