Patents by Inventor Hongjie Dai

Hongjie Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11121400
    Abstract: A metal-ion battery includes: 1) an anode including a metal; 2) a cathode; and 3) an ionic liquid electrolyte disposed between the anode and the cathode, wherein the ionic liquid electrolyte corresponds to a mixture of a metal halide and an organic compound.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: September 14, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Michael R. Angell, Yingpeng Wu, Ming Gong, Chunze Yuan
  • Publication number: 20210239955
    Abstract: Provided are methods of near-infrared II light sheet microscopy with excitation and emission up to between about 1320 nm and about 2400 nm, respectively, for optical sectioning through live tissues with improved penetration depth without any invasive surgery. The methods allow for normal and oblique configurations enabled in vivo imaging of live mice through intact tissue, revealing such as abnormal blood flow and T cell motion in tumor microcirculation and mapping out programmed-death ligand 1 and programmed cell death protein 1 (PD-1) in tumors with cellular resolution. 3D imaging through intact mouse heads resolved vascular channels between skull and brain cortex, and monitored recruitment of macrophages/microglia to traumatic brain injury site post injury.
    Type: Application
    Filed: June 4, 2019
    Publication date: August 5, 2021
    Inventors: Hongjie DAI, Feifei WANG
  • Patent number: 11022611
    Abstract: Disclosed herein are systems and methods for detecting and diagnosing flaviviral or alphaviral infections in subjects in need thereof. The systems and methods of the disclosure enable rapid testing of small volumes of biological sample with the ability to reliably distinguish between flavival and alphaviral infections and determine whether the viral infection is acute or chronic.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: June 1, 2021
    Assignee: Nirmidas Biotech, Inc.
    Inventors: Joshua T. Robinson, Meijie Tang, Su Zhao, Anna Hsu Pao, Hongjie Dai, Bo Zhang, Jeyarama Subramanian Ananta Narayanan
  • Patent number: 10894121
    Abstract: Disclosed is a small molecule dye for use in imaging in the near-infrared window, namely between 1000 nm-1700 nm wavelength. The present dyes are also useful for photoacoustic imaging and photothermal therapy. The dyes have a structure of a D-A-D (donor-acceptor-donor) fluorescent compound core and side chains rendering the compounds water soluble and easily conjugated to hydrophilic polymers and/or targeting ligands. Further disclosed is compound, CH1055 that can be PEGylated, conjugated to a targeting ligand, or conjugated to taurine. Key steps utilized to assemble the core structure of the target included a cross-Suzuki coupling reaction, iron reduction and N-thionylaniline induced ring closure. Four carboxylic acid groups were introduced into the donor-acceptor-donor (D-A-D) type fluorescent compound to impart a certain aqueous solubility and to allow facile conjugation to targeting ligands.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: January 19, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhen Cheng, Xuechuan Hong, Hongjie Dai, Hao Chen, Alexander Antaris, Kai Cheng
  • Publication number: 20210002777
    Abstract: A corrosion resistant anode is provided for oxygen evolution reaction in water including chloride ions. The anode includes: (1) a substrate; (2) a passivation layer coating the substrate; and (3) an electrocatalyst layer coating the passivation layer. Polyanion adjusted alkaline seawater electrolyte for hydrogen generation by electrolysis is also provided.
    Type: Application
    Filed: February 1, 2019
    Publication date: January 7, 2021
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael J. KENNEY, Hongjie DAI, Yun KUANG, Yongtao MENG
  • Publication number: 20200407861
    Abstract: A method of forming a cathode for hydrogen evolution reaction includes: (1) providing a substrate; (2) forming a precursor layer covering the substrate; and (3) annealing the precursor layer to form an electrocatalyst layer covering the substrate.
    Type: Application
    Filed: February 15, 2019
    Publication date: December 31, 2020
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie DAI, Jianan Erick HUANG, Michael J. KENNEY, Yun KUANG, Yongtao MENG, Xin TIAN
  • Publication number: 20200203675
    Abstract: Provided herein are new methods for making a highly stable metal anode (e.g., aluminum ion) battery. The battery includes, in some embodiments, a fluorinated material, for instance FEP or PTFE, as a chemical compatible enclosure which does not react with the electrolyte in the battery. In some examples, the batteries described herein are stable over many cycle lives and also tolerant a highly acidic electrolyte environment, even after long storage times. In some examples, the chemical compatible enclosure includes an inserted tube which allows for the removing of residual water and HCl which may be present in the battery, either as made, during use (e.g., charge-discharge cycling), or after use. Also set forth herein, in some examples, are methods of using a battery, including continuous drawing a vacuum on a battery during battery cycling.
    Type: Application
    Filed: April 10, 2018
    Publication date: June 25, 2020
    Inventors: Meng-Chang LIN, Meijie TANG, Hongjie DAI, Chun-Jern PAN, Pengfei Ql
  • Publication number: 20200158728
    Abstract: Disclosed herein are systems and methods for detecting and diagnosing flaviviral or alphaviral infections in subjects in need thereof. The systems and methods of the disclosure enable rapid testing of small volumes of biological sample with the ability to reliably distinguish between flavival and alphaviral infections and determine whether the viral infection is acute or chronic.
    Type: Application
    Filed: May 3, 2017
    Publication date: May 21, 2020
    Inventors: Joshua T. Robinson, Meijie Tang, Su Zhao, Anna Hsu Pao, Hongjie Dai, Bo Zhang, Jeyarama Subramanian Ananta Narayanan
  • Publication number: 20200132698
    Abstract: Methods of detecting ZNT8 antibodies in serum are described. The methods include proteoliposomes comprising a transmembrane domain (TMD) and a cytosolic domain (CTD) of ZnT8 proteins exposed on the exterior of the proteoliposome; serum comprising antibodies targeting the ZnT8 proteins; and labelled captured autoantibodies that bind to ZnT8 antibodies.
    Type: Application
    Filed: July 5, 2018
    Publication date: April 30, 2020
    Inventors: Dax Fu, Chengfeng Merriman, Hongjie Dai, Hao Wan
  • Patent number: 10604854
    Abstract: A cathode for water splitting production includes: (1) a porous substrate; and (2) an electrocatalyst affixed to the porous substrate. The electrocatalyst includes heterostructures of a first material and a second material that partially covers the first material.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: March 31, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Ming Gong
  • Publication number: 20190192761
    Abstract: Disclosed is a small molecule dye for use in imaging in the near-infrared window, namely between 1000 nm-1700 nm wavelength. The present dyes are also useful for photoacoustic imaging and photothermal therapy. The dyes have a structure of a D-A-D (donor-acceptor-donor) fluorescent compound core and side chains rendering the compounds water soluble and easily conjugated to hydrophilic polymers and/or targeting ligands. Further disclosed is compound, CH1055 that can be PEGylated, conjugated to a targeting ligand, or conjugated to taurine. Key steps utilized to assemble the core structure of the target included a cross-Suzuki coupling reaction, iron reduction and N-thionylaniline induced ring closure. Four carboxylic acid groups were introduced into the donor-acceptor-donor (D-A-D) type fluorescent compound to impart a certain aqueous solubility and to allow facile conjugation to targeting ligands.
    Type: Application
    Filed: November 12, 2018
    Publication date: June 27, 2019
    Inventors: Zhen CHENG, Xuechuan HONG, Hongjie DAI, Hao CHEN, Alexander ANTARIS, Kai CHENG
  • Patent number: 10264974
    Abstract: Disclosed are methods for imaging lumen-forming structures such as blood vessels using near-infrared fluorescence in the NIR-II region of 1000-1700 nm. The fluorescence is created by excitation of solubilized nano-structures that are delivered to the structures, such as carbon nanotubes, quantum dots or organic molecular fluorophores attached to hydrophilic polymers. These nanostructures fluoresce in the NIR-II region when illuminated through the skin and tissues. Fine anatomical vessel resolution down to ?30 ?m and high temporal resolution up to 5-10 frames per second is obtained for small-vessel imaging with up to 1 cm penetration depth in mouse hind limb, which compares favorably to tomographic imaging modalities such as CT and MRI with much higher spatial and temporal resolution, and compares favorably to scanning microscopic imaging techniques with much deeper penetration.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: April 23, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Guosong Hong, Jerry Chung-yu Lee, Ngan Fong Huang, John P. Cooke, Hongjie Dai
  • Patent number: 10261298
    Abstract: Disclosed are methods and devices for confocal microscopy in the near-infrared. wavelength. The device uses a near-infrared (NIR) light producing source such as laser; optical components designed to reflect and transmit NIR from a sample; and an NIR detector coupled to a computer for constructing a focal plane image from a raster scan. The detector may be a photodiode or photo-multiplier tube for detecting fluorescence signals in the NIR (800-1700 nm) wavelength range using a variety of NIR-I (800-1000 nm) and NIR-II (1000-1700 nm) dyes and nanomaterials. An imaging method is described using the NIR-confocal microscope for slice by slice 3D imaging of biological tissues throughout a thickness up to, for example, 5 mm in the NIR-II window. The reduced scattering in NIR-II allows for tissue penetration up to about 5-10 mm, superior to ˜0.2 mm afforded by conventional imaging.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: April 16, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Guosong Hong, Alexander Antaris, Shuo Diao, Hongjie Dai
  • Publication number: 20190006701
    Abstract: A metal-ion battery includes: 1) an anode including a metal; 2) a cathode; and 3) an ionic liquid electrolyte disposed between the anode and the cathode, wherein the ionic liquid electrolyte corresponds to a mixture of a metal halide and an organic compound.
    Type: Application
    Filed: December 14, 2016
    Publication date: January 3, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Michael R. Angell, Yingpeng Wu, Ming Gong, Chunze Yuan
  • Patent number: 10124111
    Abstract: Disclosed is a small molecule dye for use in imaging in the near-infrared window, namely between 1000 nm-1700 nm wavelength. The present dyes are also useful for photoacoustic imaging and photothermal therapy. The dyes have a structure of a D-A-D (donor-acceptor-donor) fluorescent compound core and side chains rendering the compounds water soluble and easily conjugated to hydrophilic polymers and/or targeting ligands. Further disclosed is compound, CH1055 that can be PEGylated, conjugated to a targeting ligand, or conjugated to taurine. Key steps utilized to assemble the core structure of the target included a cross-Suzuki coupling reaction, iron reduction and N-thionylaniline induced ring closure. Four carboxylic acid groups were introduced into the donor-acceptor-donor (D-A-D) type fluorescent compound to impart a certain aqueous solubility and to allow facile conjugation to targeting ligands.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: November 13, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhen Cheng, Xuechuan Hong, Hongjie Dai, Hao Chen, Alexander Antaris, Kai Cheng
  • Patent number: 10088478
    Abstract: Disclosed are nanostructured gold films which may be produced by solution-phase depositions of gold ions onto a variety of surfaces. The resulting plasmonic gold films are used for enhanced spectroscopic-based immunoassays in multiplexed microarray format with detection mechanisms based on either surface-enhanced Raman scattering or near-infrared fluorescence enhancement. The preparation of the films and subsequent modifications of the gold film surfaces afford increased sensitivity for various microarrays. The films are discontinuous, forming gold “islands.” Sensitivity, size, shape, and density of the nanoscopic gold islands comprising the discontinuous nanostructured gold film are controlled to enhance the intensity of Raman scattering and fluorescence in the near-infrared, allowing for improved measurements in clinical diagnostic or biomedical research applications.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: October 2, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Scott M. Tabakman, Guosong Hong, Bo Zhang
  • Patent number: 9991391
    Abstract: Disclosed are dispersed graphene sheets, ribbons, graphene molecules and the like which are pristine in the plane, i.e., free of significant defects and chemical modifications such as oxidation. The materials could be functionalized at the edges. These materials are dispersed in solutions rather than in aggregated or insoluble forms as their parent starting materials. Also disclosed is a method comprising the steps of intercalating an insoluble graphitic material. The method may comprise exfoliating graphite and re-intercalating the resultant material with an acid composition, such as oleum, and a strong organic base such as tetrabutylammonium hydroxide in a solvent solution to form a homogenous suspension, which is then agitated to form dispersed graphene materials. The materials may be solubilized with a hydrophilic polymer and can be further manipulated by transfer into different solvents, formation of films, application to optical and electronic devices, and other applications.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: June 5, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Xiaolin Li, Xiaoming Sun
  • Patent number: 9843070
    Abstract: A metal-ion battery includes: (1) an anode including aluminum; (2) a cathode including a layered, active material; and (3) an electrolyte disposed between the anode and the cathode to support reversible deposition and dissolution of aluminum at the anode and reversible intercalation and de-intercalation of anions at the cathode.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: December 12, 2017
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Industrial Technology Research Institute
    Inventors: Hongjie Dai, Meng-Chang Lin, Ming Gong, Bingan Lu, Yingpeng Wu
  • Patent number: 9823246
    Abstract: Disclosed are nanostructured gold films which may be produced by solution-phase depositions of gold ions onto a variety of surfaces. The resulting plasmonic gold films are used for enhanced spectroscopic-based immunoassays in multiplexed microarray format with detection mechanisms based on either surface-enhanced Raman scattering or near-infrared fluorescence enhancement. The preparation of the films and subsequent modifications of the gold film surfaces afford increased sensitivity for various microarrays. The films are discontinuous, forming gold “islands.” Sensitivity, size, shape, and density of the nanoscopic gold islands comprising the discontinuous nanostructured gold film are controlled to enhance the intensity of Raman scattering and fluorescence in the near-infrared, allowing for improved measurements in clinical diagnostic or biomedical research applications.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: November 21, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hongjie Dai, Scott M. Tabakman, Guosong Hong, Bo Zhang
  • Publication number: 20170266323
    Abstract: Embodiments of the present disclosure provide for compositions including organic, water-soluble NIR-II fluorescent agent that emit radiation at about 1.0 to 1.7 ?m, methods of making the composition, methods of imaging a disease and related biological events, methods of imaging, monitoring and/or assessing a disease and related biological events, and the like.
    Type: Application
    Filed: June 1, 2017
    Publication date: September 21, 2017
    Inventors: Zhimin Tao, Guosong Hong, Yingping Zou, Chihiro Fukunaga, Hongjie Dai, Shuo Diao, Alex Antaris