Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: The present invention discloses an N-alkyl-N-cyanoalkylbenzamide compound of General Formula I, an intermediate of General Formula II used to prepare the compound, wherein R1 is selected from halo or C1-C3 alkyl; R2 is selected from halo or CN; R3 is selected from halo, or C1-C3haloalkyl; R4 is selected from halo; R5 is selected from H or halo; R6 is selected from C1-C3alkyl, C1-C3 haloalkyl or C1-C5 alkoxyalkyl; R7 is selected from C1-C5 alkyl; and R8 is selected from hydrogen or C1-C5alkyl. Compared with the compounds in the prior art, the compound of General Formula I has a higher activity at a low concentration. Particularly, the compound of the present invention still has 60% or higher of the insecticidal activity at a concentration below 1 ppm. This greatly reduces the amount of the compound used and the residue of the compound in farmland, and is thus environmentally friendly.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: The present invention discloses a pyrazolamide compound of General Formula I having an insecticidal activity and an intermediate of General Formula II used to preparing the compound of General Formula I, wherein R1 is selected from chloro or CN, R2 is selected from H, C1-C3 alkyl, C1-C3 haloalkyl or C1-C5 alkoxyalkyl, R3 is selected from halo or C1-C3 haloalkyl, R4 is selected from halo, and R5 is selected from H or halo. Compared with the compounds in the prior art, the compound of General Formula I of the present invention has a higher activity at a low concentration. This reduces the amount of the compound used and the residue of the compound in farmland, and is thus environmentally friendly.

Abstract: A battery replacement device including a first linear motion mechanism, a second linear motion mechanism mounted on the first linear motion mechanism, a third linear motion mechanism mounted on the second linear motion mechanism, and a clamp mechanism mounted on one of the first, second, and third linear motion mechanisms. Each of the first, second, and third linear motion mechanisms includes a carrying member and a driving member configured to drive the carrying member to move translationally in one of a first axis direction, a second axis direction, and a third axis direction that build a three-dimensional Cartesian coordinate system. A coordinate position of the clamp mechanism in the three-dimensional Cartesian coordinate system is adjusted by the first driving member, the second driving member, and the third driving member.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: An unmanned aerial vehicle (UAV) base station includes a housing and a UAV fixation system. The housing includes a top-plate configured for a UAV to land on the top-plate. The UAV fixation system is configured to direct the UAV present on the top-plate to a battery-exchange zone of the top-plate.

Abstract: A unmanned aerial vehicle (UAV) base station for automated battery pack exchange and methods for manufacturing and using the same. The UAV base station includes a battery-exchange system disposed within a housing having a top-plate. The housing contains a battery array having a plurality of UAV battery packs and a mechanical mechanism for automatically removing an expended battery pack from a UAV that lands on the top-plate and replacing the expended battery pack with a charged battery pack. Thereby, the UAV base station system advantageously enables extended and autonomous operation of the UAV without the need for user intervention for exchanging UAV battery packs.

Abstract: A battery replacement device including a first linear motion mechanism, a second linear motion mechanism mounted on the first linear motion mechanism, a third linear motion mechanism mounted on the second linear motion mechanism, and a clamp mechanism mounted on one of the first, second, and third linear motion mechanisms. Each of the first, second, and third linear motion mechanisms includes a carrying member and a driving member configured to drive the carrying member to move translationally in one of a first axis direction, a second axis direction, and a third axis direction that build a three-dimensional Cartesian coordinate system. A coordinate position of the clamp mechanism in the three-dimensional Cartesian coordinate system is adjusted by the first driving member, the second driving member, and the third driving member.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: All unmanned aerial vehicle dock includes a base plate, a battery replacement device for replacing a battery of an unmanned aerial vehicle, and a battery compartment mounted on the base plate and configured to receive and charge the battery. The battery replacement device includes a first linear motion mechanism mounted on the base plate, a second linear motion mechanism mounted on the first linear motion mechanism, a third linear motion mechanism mounted on the second linear motion mechanism, and a clamp mechanism mounted on the third linear motion mechanism.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: Cassettes comprising a YAO promoter operably linked to at least one nucleotide sequence encoding a nuclease, vectors comprising the same are provided. A system for altering a plant genome comprising a nucleotide sequence encoding a nuclease operably linked to a YAO promoter and a method to alter the target nucleic acid molecule by using the system are provided. Plants, progeny and seeds thereof having such altered target nucleic acid molecules are also provided.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: All unmanned aerial vehicle dock includes a base plate, a battery replacement device for replacing a battery of an unmanned aerial vehicle, and a battery compartment mounted on the base plate and configured to receive and charge the battery. The battery replacement device includes a first linear motion mechanism mounted on the base plate, a second linear motion mechanism mounted on the first linear motion mechanism, a third linear motion mechanism mounted on the second linear motion mechanism, and a clamp mechanism mounted on the third linear motion mechanism.

Abstract: A unmanned aerial vehicle (UAV) base station for automated battery pack exchange and methods for manufacturing and using the same. The UAV base station includes a battery-exchange system disposed within a housing having a top-plate. The housing contains a battery array having a plurality of UAV battery packs and a mechanical mechanism for automatically removing an expended battery pack from a UAV that lands on the top-plate and replacing the expended battery pack with a charged battery pack. Thereby, the UAV base station system advantageously enables extended and autonomous operation of the UAV without the need for user intervention for exchanging UAV battery packs.

Abstract: The invention is concerned with the compounds of formula (I): and salts thereof, wherein X, Y, Z, R1, R2, R3, R3?, R4, R5 and R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Abstract: The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists of the TRPA1 channel and may be useful in treating inflammatory diseases and disorders associated with that channel.

Abstract: The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein Y, R1, R2 and R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists of the TRPA1 channel and may be useful in treating inflammatory diseases and disorders associated with that channel.