Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH2 receptor.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R1, R2, R7, R8a, E, Y, Z, n, u, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.

Abstract: The present invention relates to compounds according to Formula (I) or a pharmaceutically acceptable salt or solvate thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or condition.

Abstract: A reciprocating servo control device for a mainshaft of a honing machine includes a bed body, a mainshaft mechanism, a driving system for hydraulic reversing and a control system, the driving system includes a mainshaft hydraulic cylinder and a mechanical-hydraulic servo valve, a valve body of the mechanical-hydraulic servo valve is connected to a piston rod of the mainshaft hydraulic cylinder via a connecting mechanism, a spool of the mechanical-hydraulic servo valve is connected to one end of a first connecting member, and the other end of the first connecting member is connected to a pilot displacement mechanism controlled by a servo driving and control system. The reciprocating servo control device adopts a mechanical position closed-loop and a hydraulic position closed-loop, to achieve numerical control of speed, position and reversing of the mainshaft hydraulic cylinder, thus a simple structure, reliable control, low price and easy adjustment can be realized.

Abstract: The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R1, R2, R7, R8, R8a, E, Y, Z, n, u, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.

Abstract: The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J1, J2, R1, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.

Abstract: This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH2 receptor.

Abstract: Apparatus (48), and an associated method, for facilitating effectuation of control over when a mobile node (12) operable in a communication system (10) generates control signaling pursuant to a control procedure (62), such as a network search and selection procedure (64) or a registration procedure (66). A determiner (52) determines whether prior-sent control signals appear to have been successfully delivered to the network. If not, a selector (54) selects whether to increase a wait period prior to commencement of a subsequent control procedure, such as another network searching and selection procedure.

Abstract: The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R1, R2, R7, R8, R8a, E, Y, Z, n, u, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.

Abstract: Methods for detecting strains of Clostridium difficile (e.g. toxigenic and non-toxigenic) in a specimen are disclosed. Oligonucleotide primer pairs based on the sequences of multiple loci of the bacteria are disclosed. In one application, up to five loci in the genomic DNA sequences of Clostridium difficile were amplified. Two fragments of C. difficile were amplified from each locus, wherein a second fragment was an internal fragment of the first fragment.

Abstract: Apparatus (48), and an associated method, for facilitating operation of a mobile node (12) operable in a communication system (10) to request allocation of communication capacity upon which to communicate data pursuant to a communication service. A channel allocation request generator (52) is selectably operable to generate requests for allocation of channel capacity upon which to communicate the data. A selector (54) selects when to cause the generator (52) to communicate the additional data packets. Selection is made to delay, or otherwise prevent, retransmission of requests, when a determination is made that the retransmission is unlikely to be successful.

Abstract: Apparatus (48), and an associated method, for facilitating operation of a mobile node (12) operable in a communication system (10) to request allocation of communication capacity upon which to communicate data pursuant to a communication service. A channel allocation request generator (52) is selectably operable to generate requests for allocation of channel capacity upon which to communicate the data. A selector (54) selects when to cause the generator (52) to communicate the additional data packets. Selection is made to delay, or otherwise prevent, retransmission of requests, when a determination is made that the retransmission is unlikely to be successful.

Abstract: Apparatus (48), and an associated method, for facilitating operation of a mobile node (12) operable in a communication system (10) to request allocation of communication capacity upon which to communicate data pursuant to a communication service. A channel allocation request generator (52) is selectably operable to generate requests for allocation of channel capacity upon which to communicate the data. A selector (54) selects when to cause the generator (52) to communicate the additional data packets. Selection is made to delay, or otherwise prevent, retransmission of requests, when a determination is made that the retransmission is unlikely to be successful.

Abstract: The present invention provides a travelway structure for maglev transportation comprises: a travelway girder having a concrete girder plate extending from two sides of the travelway girder; a pre-embedded member pre-embedded in the concrete girder plate; and a detachable member installed on the pre-embedded member via a fastener, wherein the pre-embedded member is machinable, and a position for installing the detachable member on the pre-embedded member is formed by a machining process after the travelway girder experiences deformations which lead to errors. A method for manufacturing a travelway structure for maglev transportation is also provided according to the present invention. Specifically, after a period of time, during which the travelway girder experiences most of the deformations caused by pre-stressed tension and gradual contraction and the like, the travelway girder along with the pre-embedded pieces are moved to the machine tools for machining the functional pre-embedded member.

Abstract: Apparatus (48), and an associated method, for facilitating operation of a mobile node (12) operable in a communication system (10) to request allocation of communication capacity upon which to communicate data pursuant to a communication service. A channel allocation request generator (52) is selectably operable to generate requests for allocation of channel capacity upon which to communicate the data. A selector (54) selects when to cause the generator (52) to communicate the additional data packets. Selection is made to delay, or otherwise prevent, retransmission of requests, when a determination is made that the retransmission is unlikely to be successful.

Abstract: Apparatus (48), and an associated method, for facilitating effectuation of control over when a mobile node (12) operable in a communication system (10) generates control signaling pursuant to a control procedure (62), such as a network search and selection procedure (64) or a registration procedure (66). A determiner (52) determines whether prior-sent control signals appear to have been successfully delivered to the network. If not, a selector (54) selects whether to increase a wait period prior to commencement of a subsequent control procedure, such as another network searching and selection procedure.