Abstract: A bionic nerve graft and a preparation method thereof is provided. The bionic nerve graft includes a helical stent, a nanofiber membrane, guide fibers and hBMSC-ECM. A surface of the helical stent is coated with the nanofiber membrane, the guide fibers and the hBMSC-ECM are placed in a tube cavity of the helical stent, and the raw materials of the helical stent, the nanofiber membrane and the guide fibers are all chitosan. The preparation method includes the following steps: preparing the helical stent by a mold pouring method, coating the surface of the helical stent with the nanofiber membrane by an electrostatic spinning method, preparing the guide fibers by a template method, and filling the guide fibers and the hBMSC-ECM in the helical stent with the surface coated with the nanofiber membrane.

Abstract: A cell matrix nerve graft for repairing peripheral nerve injury and a preparation method thereof are provided. The cell matrix nerve graft comprises acellular matrix and a scaffold, wherein the acellular matrix is obtained by decellularization after secretion and formation of stem cells, and the acellular matrix is wrapped around the scaffold. The defects of autologous nerve transplantation repair can be overcome and the immunogenicity of allogeneic cell transplantation repair is avoided. The cell matrix nerve graft beneficial to nerve cell proliferation and migration is provided, a microenvironment beneficial to axon growth is established, the purposes of nerve regeneration and function repair are achieved, and a feasible solution is provided for clinical treatment of nerve defects.

Abstract: A differential tissue-engineered nerve including motor-like nerves and sensory-like nerves. The motor-like nerve and the sensory-like nerve respectively includes a motor-like nerve outer tube and a motor-like nerve fiber in the outer tube as well as a sensory-like nerve outer tube and a sensory-like nerve fiber in the outer tube. Schwann cells and/or fibroblasts derived from motor nerves and sensory nerves are respectively contained in surfaces or pores of the motor-like and sensory-like nerve outer tubes. Transsynaptic signal molecules Neuroligin-1 and Neuroligin-2 are contained in surfaces or pores of the motor-like and sensory-like nerve fibers. Neuroligin-1 is selectively used to specifically promote synaptic remodeling of motor neurons, while Neuroligin-2 is selectively used to specifically promote synaptic remodeling of sensory neurons, so that repair efficiency of motor nerve cells and sensory nerve cells is improved.

Abstract: A differential tissue-engineered nerve including motor-like nerves and sensory-like nerves. The motor-like nerve and the sensory-like nerve respectively includes a motor-like nerve outer tube and a motor-like nerve fiber in the outer tube as well as a sensory-like nerve outer tube and a sensory-like nerve fiber in the outer tube. Schwann cells and/or fibroblasts derived from motor nerves and sensory nerves are respectively contained in surfaces or pores of the motor-like and sensory-like nerve outer tubes. Transsynaptic signal molecules Neuroligin-1 and Neuroligin-2 are contained in surfaces or pores of the motor-like and sensory-like nerve fibers. Neuroligin-1 is selectively used to specifically promote synaptic remodeling of motor neurons, while Neuroligin-2 is selectively used to specifically promote synaptic remodeling of sensory neurons, so that repair efficiency of motor nerve cells and sensory nerve cells is improved.

Abstract: The present invention provides a visual fractional laser instrument, which comprises: an positioning cannula, the positioning cannula being a hollow tube with openings at both ends so as to locate a lesion site and define a path of the laser; a beam combiner component, the beam combiner component being a hollow tube with openings at both ends, and a side opening is provided on a side of the beam combiner component, wherein one end of the beam combiner component is connected to one end of the positioning cannula; a camera connected to the beam combiner component by the side opening to image the lesion site; a laser scanning component connected to another end of the beam combiner component for generating a laser beam used to scan the lesion site according to the image of the lesion site; and a control system connected to the laser scanning component and the camera, respectively.

Abstract: The present invention provides a visual fractional laser instrument, which comprises: an positioning cannula, the positioning cannula being a hollow tube with openings at both ends so as to locate a lesion site and define a path of the laser; a beam combiner component, the beam combiner component being a hollow tube with openings at both ends, and a side opening is provided on a side of the beam combiner component, wherein one end of the beam combiner component is connected to one end of the positioning cannula; a camera connected to the beam combiner component by the side opening to image the lesion site; a laser scanning component connected to another end of the beam combiner component for generating a laser beam used to scan the lesion site according to the image of the lesion site; and a control system connected to the laser scanning component and the camera, respectively.

Abstract: Devices, components, apparatus, and/or methods for using and making a combination spinal disk herniation repositioning and radiofrequency apparatus (RFA) or device that uses one or more repositioning probes and one or more needles/electrodes, wherein the device's probe repositions, and the electrode or needle treats or ablates, an injured, torn, herniated, or displaced vertebral disc propulus and/or nucleus, and wherein one or more side probes or needles are used to reposition or treat the spinal disk herniation, optionally followed by medicine/ozone therapy of the disc being treated.

Abstract: Devices, components, apparatus, and/or methods for using and making a combination spinal disk herniation repositioning and radiofrequency apparatus (RFA) or device that uses one or more repositioning probes and one or more needles/electrodes, wherein the device's probe repositions, and the electrode or needle treats or ablates, an injured, torn, herniated, or displaced vertebral disc propulus and/or nucleus, and wherein one or more side probes or needles are used to reposition or treat the spinal disk herniation, optionally followed by medicine/ozone therapy of the disc being treated.