Abstract: A replicating oncolytic virus vector is provided having a modified Enterovirus genome (e.g., a Poliovirus, Coxsackievirus or Echovirus genome), wherein the modified Enterovirus genome has one or more copies of one or more miRNA target sequences operably linked to an untranslated region (UTR) of the Enterovirus genome. Also provided are compositions and methods for treating cancer (including for example, lung cancer).

Abstract: A method for determining 3D primitive reciprocal basis of an unknown crystal based on a single EBSD pattern includes steps of geometrically correcting all visible Kikuchi bands with the pattern center and the detector distance used for obtaining corresponding reciprocal vectors, and determining components of the corresponding reciprocal vectors in a 3D reciprocal Cartesian coordinate system, so as to obtain a 3D primitive reciprocal basis. The method given in the present invention is able to effectively exclude fake primitive cells; correctly identify the volume of a primitive cell even though the presence of obvious errors in the width of the Kikuchi bands; and successfully determine a 3D primitive reciprocal basis of unknown crystals based on a single EBSD pattern.

Abstract: A method for determining 3D primitive reciprocal basis of an unknown crystal based on a single EBSD pattern includes steps of geometrically correcting all visible Kikuchi bands with the pattern center and the detector distance used for obtaining corresponding reciprocal vectors, and determining components of the corresponding reciprocal vectors in a 3D reciprocal Cartesian coordinate system, so as to obtain a 3D primitive reciprocal basis. The method given in the present invention is able to effectively exclude fake primitive cells; correctly identify the volume of a primitive cell even though the presence of obvious errors in the width of the Kikuchi bands; and successfully determine a 3D primitive reciprocal basis of unknown crystals based on a single EBSD pattern.

Abstract: A method for determining geometric relationships of crystal reciprocal vectors on the two-dimensional planes obtained from an EBSD pattern includes steps of: geometrically correcting Kikuchi bands for obtaining the reciprocal vectors corresponding to the Kikuchi bands; selecting a set of reciprocal vectors which define a parallelogram with minimum area on the reciprocal plane as a two-dimensional basis for forming a grid, marking the basis; determining integer coordinates of other reciprocal vectors on the reciprocal plane relative to the basis, obtaining the deviations of the integer coordinates from the nearest grid nodes, marking the reciprocal vector with minimum deviation; fitting the length and the angel of the basis, redefining a new two-dimensional grid by the fitting result; repeating till all reciprocal vectors on the reciprocal plane are marked, wherein integer coordinates of the reciprocal vectors relative to the last two-dimensional basis now disclose the geometric relationships.

Abstract: A method for determining geometric relationships of crystal reciprocal vectors on the two-dimensional planes obtained from an EBSD pattern includes steps of: geometrically correcting Kikuchi bands for obtaining the reciprocal vectors corresponding to the Kikuchi bands; selecting a set of reciprocal vectors which define a parallelogram with minimum area on the reciprocal plane as a two-dimensional basis for forming a grid, marking the basis; determining integer coordinates of other reciprocal vectors on the reciprocal plane relative to the basis, obtaining the deviations of the integer coordinates from the nearest grid nodes, marking the reciprocal vector with minimum deviation; fitting the length and the angel of the basis, redefining a new two-dimensional grid by the fitting result; repeating till all reciprocal vectors on the reciprocal plane are marked, wherein integer coordinates of the reciprocal vectors relative to the last two-dimensional basis now disclose the geometric relationships.