Abstract: A vehicle seat restraint system includes a control system and a second-row restraint system. The control system receives a first-row seat value and a second-row seat value from seat sensors. The control system generates relative position data for a first-row seat and a second-row seat based upon the first-row seat value and the second-row seat value. The control system selects a load limiter setting value using a multidimensional load limiter model based upon body impact values as a function of load limiter setting values and the relative position data, a selected load limiter setting value outside a value avoidance zone for the body impact values. The second-row restraint system is configured by the control system with the selected load limiter setting value. The control system may also determine an occupant weight value and select the load limiter setting value using the occupant weight value.

Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: A vehicle seat restraint system includes a control system and a second-row restraint system. The control system receives a first-row seat value and a second-row seat value from seat sensors. The control system generates relative position data for a first-row seat and a second-row seat based upon the first-row seat value and the second-row seat value. The control system selects a load limiter setting value using a multidimensional load limiter model based upon body impact values as a function of load limiter setting values and the relative position data, a selected load limiter setting value outside a value avoidance zone for the body impact values. The second-row restraint system is configured by the control system with the selected load limiter setting value. The control system may also determine an occupant weight value and select the load limiter setting value using the occupant weight value.

Abstract: A process is provided that uses a sensor system incorporated into the passenger cabin of a vehicle to detect children and/or pets left unattended and who are therefore at risk of serious injury or death due to heat stroke. If an unattended child or pet is detected, a variety of alerts are issued over time, the escalating nature of the alerts intended to insure a rapid response. After the system has operated long enough to insure that no child or pet has been left behind, the sensor system is automatically placed into a standby mode. In standby mode the sensor system may either be turned completely off in order to minimize off-line power consumption or it may be incorporated into an on-board security system.

Abstract: A method includes: determining first and second row seat values using seat sensors; generating relative position data for the seats using the values; selecting a load limiter setting value using the relative position data and a multidimensional load limiter model including at least i) body impact values as a function of at least load limiter setting values and as a function of relative position values, and ii) restraint interaction values as a function of at least the load limiter setting values and as a function of the relative position values, the load limiter setting value selected so that the load limiter setting value is outside a first value avoidance zone defined for the body impact values, and outside a second value avoidance zone for the restraint interaction values; and configuring a second row restraint system in the vehicle with the selected load limiter setting value.

Abstract: A sensor system is provided that is incorporated into the passenger cabin of a vehicle and which is configured to detect children and/or pets left unattended and who are therefore at risk of serious injury or death due to heat stroke. The system is designed to transmit a variety of alerts over time after an unattended child or pet is detected, the escalating nature of the alerts intended to insure a rapid response. After the system has operated long enough to insure that no child or pet has been left behind, the sensor system is automatically placed into a standby mode. In standby mode the sensor system may either be turned completely off in order to minimize off-line power consumption or it may be incorporated into an on-board security system.

Abstract: A method includes: determining first and second row seat values using seat sensors; generating relative position data for the seats using the values; selecting a load limiter setting value using the relative position data and a multidimensional load limiter model including at least i) body impact values as a function of at least load limiter setting values and as a function of relative position values, and ii) restraint interaction values as a function of at least the load limiter setting values and as a function of the relative position values, the load limiter setting value selected so that the load limiter setting value is outside a first value avoidance zone defined for the body impact values, and outside a second value avoidance zone for the restraint interaction values; and configuring a second row restraint system in the vehicle with the selected load limiter setting value.

Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in intro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Described herein is the synthesis and pharmacology of a series of ?-substituted methylene phosphonate analogs, in which the ?-CH2 moiety is replaced with CHCl or CHBr.

Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Described herein is the synthesis and pharmacology of a series of ?-substituted methylene phosphonate analogs, in which the ?-CH2 moiety is replaced with CHCl or CHBr.