Abstract: In certain aspects, disclosed herein are methods of treating cancer in a subject, comprising administration to the subject of (1) one or more glucocorticoid receptor agonists and (2) one or more inhibitors of calcineurin. In some embodiments, the administration of the one or more glucocorticoid receptor agonists and the one or more inhibitors of calcineurin results in restoration of contact inhibition, increased formation of intercellular junctions, reduced cell proliferation, and/or increased vacuolization of cells growing in multilayer zones. Included herein are methods for identification of novel compounds that restore contact inhibition in cancer cells.

Abstract: The disclosure provides a digital contactless signing system for the flexible tobacco distribution, which comprises a cigarette store, a vehicle system, a vehicle access system, a database, a historical database, a server, an information entry unit, an information transmission unit, a distribution system, a client terminal and a two-dimensional code information unit, wherein the cigarette store is connected with the vehicle access system connected with the vehicle access system. The disclosure changes paper tickets into network electronic tickets, and adopts two-dimension code scanning to complete a confirmation of the tobacco handing-over between a distributor and a customer, thereby effectively saving expenses of the paper tickets. An error rate of the signing system is extremely low and almost close to zero due to changing the paper tickets to the network electronic tickets, and a whole data accuracy is improved for signing for the cigarette materials.