Patents by Inventor Hongmei R. Xing

Hongmei R. Xing has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
    Patent number: 8283459
    Abstract: The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gf Ras mediated tumorigenesis, metastasis, and for cancer therapy are provided. Methods for conferring radiosensitivity to cells are also provided.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: October 9, 2012
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Richard N. Kolesnick, Hongmei R. Xing
  • Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
    Patent number: 8258108
    Abstract: The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gfRas mediated tumorigenesis, metastasis, and for cancer therapy are provided. Methods for conferring radiosensitivity to cells are also provided.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: September 4, 2012
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Richard N. Kolesnick, Hongmei R. Xing
  • Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
    Publication number: 20090143320
    Abstract: The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gf Ras mediated tumorigenesis, metastasis, and for cancer therapy are provided. Methods for conferring radiosensitivity to cells are also provided.
    Type: Application
    Filed: October 12, 2007
    Publication date: June 4, 2009
    Inventors: Richard N. Kolesnick, Hongmei R. Xing
  • Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
    Patent number: 7528116
    Abstract: The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gf Ras mediated tumorigenesis, metastasis, and for cancer therapy are provided.
    Type: Grant
    Filed: May 29, 2003
    Date of Patent: May 5, 2009
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Richard N. Kolesnick, Hongmei R. Xing
  • Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
    Patent number: 7301017
    Abstract: The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gƒ Ras mediated tumorigenesis, metastasis, and for cancer therapy are provided. Methods for conferring radiosensitivity to cells are also provided.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: November 27, 2007
    Inventors: Richard N. Kolesnick, Hongmei R. Xing