Patents by Inventor Hongmei Zhao

Hongmei Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210285063
    Abstract: The present disclosure provides a genome-wide maize SNP array and use thereof. In the present disclosure, by means of large-scale sequencing mining, aiming at the problems of the existing high-density arrays of maize, 400 broadly representative maize inbred lines inside and outside of China are deeply sequenced to mine excellent loci therefrom, and research results of six maize arrays are integrated; by adopting the steps of biological information data analysis, locus basic parameter evaluation, probe design evaluation, a set of SNP locus combination, containing 1,536 loci, is formed, and genotyping is realized on an Affymetrix axiom platform. The genome-wide maize SNP array of the present disclosure contains probes for the 1,536 SNP loci. The array of the present disclosure can be used in DNA fingerprint construction, cultivar identification and confirmation of maize cultivars, research on germplasm resources at a genomic level, and molecular marker-assisted selective breeding.
    Type: Application
    Filed: November 27, 2020
    Publication date: September 16, 2021
    Applicant: Beijing Academy of Agriculture and Forestry Sciences
    Inventors: Fengge Wang, Hongli Tian, Jiuran Zhao, Yang Yang, Hongmei Yi, Liwen Xu, Rui Wang, Lu Wang, Jianrong Ge, Yaming Fan
  • Patent number: 10915410
    Abstract: Embodiments of the present disclosure relate to methods, systems, and computer program products for managing a distributed system. In one embodiment, a computer-implemented method is disclosed. In the method, packets that are to be transmitted among a group of nodes in a distributed system may be collected into a queue of packets, here a packet in the queue is associated with a source node and a destination node in the group of nodes. A snapshot in the group of snapshots may be obtained from a node in the group of nodes, therefore a group of snapshots may be obtained from the group of nodes. A snapshot of the distributed system may be generated based on the queue of packets and the group of snapshots. In other embodiments, a computer-implemented system and a computer program product for managing a distributed system are disclosed.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: February 9, 2021
    Assignee: International Business Machines Corporation
    Inventors: Jiang Xuan, Xin Peng Liu, Peng Hui Jiang, Hongmei Zhao
  • Patent number: 10900031
    Abstract: Provided in the present invention is a method for constructing a high-resolution single cell Hi-C library with a large amount of information, comprising the following steps: Step B: obtain a small amount of fixed chromatin; Step C: digest the fixed chromatin in Step B to obtain fragments of the fixed chromatin; Step D: reconnect the fragments of the fixed chromatin in Step C directly to obtain reconnected fragments of the fixed chromatin; Step E: de-fix the reconnected fragments of the fixed chromatin in Step D to release DNA fragments; Step F: amplify the released DNA fragments in Step E to obtain amplified products; and Step H: construct a sequencing DNA library by using the amplified products as the DNA fragments to be sequenced.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: January 26, 2021
    Assignees: ZHEJIANG ANNOROAD BIO-TECHNOLOGY CO. LTD., ANNOROAD GENE TECHNOLOGY (BEIJING) CO., LTD.
    Inventors: Xiaolin Li, Jiezhong Zhang, Hongmei Zhao, Zhihua Pei, Zhaoling Xuan, Dawei Li, Junbin Liang, Chongjian Chen
  • Publication number: 20200317761
    Abstract: Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.
    Type: Application
    Filed: March 13, 2020
    Publication date: October 8, 2020
    Inventors: Christian BEIL, William H. BRONDYK, Yangde CHEN, Seng H. CHENG, Timothy D. CONNORS, Catherine DEVAUD, Dietmar HOFFMANN, Christian LANGE, Maureen MAGNAY, Tristan MAGNAY, Catherine PRADES, Ercole RAO, Leila SEVIGNY, Ronnie WEI, Hongmei ZHAO, Yunxiang ZHU
  • Patent number: 10626169
    Abstract: Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: April 21, 2020
    Assignee: Sanofi
    Inventors: Christian Beil, William H. Brondyk, Yangde Chen, Seng H. Cheng, Timothy D. Connors, Catherine Devaud, Dietmar Hoffmann, Christian Lange, Maureen Magnay, Tristan Magnay, Catherine Prades, Ercole Rao, Leila Sevigny, Ronnie Wei, Hongmei Zhao, Yunxiang Zhu
  • Publication number: 20200104215
    Abstract: Embodiments of the present disclosure relate to methods, systems, and computer program products for managing a distributed system. In one embodiment, a computer-implemented method is disclosed. In the method, packets that are to be transmitted among a group of nodes in a distributed system may be collected into a queue of packets, here a packet in the queue is associated with a source node and a destination node in the group of nodes. A snapshot in the group of snapshots may be obtained from a node in the group of nodes, therefore a group of snapshots may be obtained from the group of nodes. A snapshot of the distributed system may be generated based on the queue of packets and the group of snapshots. In other embodiments, a computer-implemented system and a computer program product for managing a distributed system are disclosed.
    Type: Application
    Filed: September 27, 2018
    Publication date: April 2, 2020
    Inventors: Jiang Xuan, Xin Peng Liu, Peng Hui Jiang, Hongmei Zhao
  • Publication number: 20190316792
    Abstract: A vent pipe, including: a top plate; two side plates; a base plate; and an air channel formed by the top plate, the two side plates, and the base plate; and an air deflector. The air channel includes a first air inlet and a first air outlet. The air deflector is disposed on the base plate and located on one side of the first air outlet. Also provided is a blower, including a motor; a volute; a blade wheel; and the vent pipe. The volute includes a chamber and the blade wheel is disposed in the chamber. The volute includes a second air inlet and a second air outlet both communicating with the chamber. The motor is disposed on the volute. The vent pipe communicates with the second air outlet.
    Type: Application
    Filed: June 28, 2019
    Publication date: October 17, 2019
    Inventors: Chenglin LIANG, Hongmei ZHAO, Wei LEI, Shuangxi SONG, Baixian XIAO, Huixiu CHEN
  • Publication number: 20180305685
    Abstract: Provided in the present invention is a method for constructing a high-resolution single cell Hi-C library with a large amount of information, comprising the following steps: Step B: obtain a small amount of fixed chromatin; Step C: digest the fixed chromatin in Step B to obtain fragments of the fixed chromatin; Step D: reconnect the fragments of the fixed chromatin in Step C directly to obtain reconnected fragments of the fixed chromatin; Step E: de-fix the reconnected fragments of the fixed chromatin in Step D to release DNA fragments; Step F: amplify the released DNA fragments in Step E to obtain amplified products; and Step H: construct a sequencing DNA library by using the amplified products as the DNA fragments to be sequenced.
    Type: Application
    Filed: October 19, 2015
    Publication date: October 25, 2018
    Applicants: NANJING ANNOROAD GENE TECHNOLOGY CO., LTD, ANNOROAD GENE TECHNOLOGY (BEIJING) CO., LTD
    Inventors: Xiaolin LI, Jiezhong ZHANG, Hongmei ZHAO, Zhihua PEI, Zhaoling XUAN, Dawei LI, Junbin LIANG, Chongjian CHEN
  • Publication number: 20180237511
    Abstract: Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.
    Type: Application
    Filed: February 16, 2018
    Publication date: August 23, 2018
    Inventors: Christian Beil, William H. Brondyk, Yangde Chen, Seng H. Cheng, Timothy D. Connors, Catherine Devaud, Dietmar Hoffmann, Christian Lange, Maureen Magnay, Tristan Magnay, Catherine Prades, Ercole Rao, Leila Sevigny, Ronnie Wei, Hongmei Zhao, Yunxiang Zhu
  • Patent number: 9994775
    Abstract: A process for producing mesophase pitch from high-temperature coal tar comprises: removing salts and quinoline insoluble fraction from a high-temperature coal tar to obtain a decant oil; using the decant oil as a hydrogenation feedstock, or pre-distilling the decant oil to obtain a residue with a boiling point higher than 230 and formulating the residue into a hydrogenation feedstock; catalytic hydrorefining the hydrogenation feedstock to obtain a hydrofined oil; distilling the hydrofined oil to obtain hydrogenated pitch; and subjecting the hydrogenated pitch to the thermal polymerization to obtain the mesophase pitch. The process has features such as an easily controllable degree of hydrogenation, complete removal of impurities, good raw material flowability, not tending to form the carbon deposition and the coking during the process, and not tending to jam the reactor. The product has a high content of mesophase pitch, a low softening point and a low impurity content.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: June 12, 2018
    Assignees: ECO ENVIRONMENTAL ENERGY RESEARCH INSTITUTE LIMITED, DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Hongmei Zhao, Jieshan Qiu, Kam Shing Philip Siu, Baoming Li, Junde Steve Lu, Nan Xiao
  • Publication number: 20170281593
    Abstract: The disclosure provides methods for treating fatty liver disease and associated conditions by inhibiting the synthesis of glucosphingolipids, as exemplified by the use of glucosylceramide synthase substrate analogs.
    Type: Application
    Filed: December 19, 2016
    Publication date: October 5, 2017
    Inventors: Hongmei Zhao, Nelson S. Yew, Seng H. Cheng, Canwen Jiang, Cynthia Marie Arbeeny
  • Patent number: 9556155
    Abstract: The disclosure provides methods for treating fatty liver disease and associated conditions by inhibiting the synthesis of glucosphingolipids, as exemplified by the use of glucosylceramide synthase substrate analogs.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: January 31, 2017
    Assignee: Genzyme Corporation
    Inventors: Hongmei Zhao, Nelson S. Yew, Seng H. Cheng, Canwen Jiang, Cynthia Marie Arbeeny
  • Patent number: 9532976
    Abstract: The invention provides methods of treating a diabetic subject comprising administering a glucosylceramide synthase inhibitor to the subject.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: January 3, 2017
    Assignee: Genzyme Corporation
    Inventors: Seng H. Cheng, Nelson S. Yew, Ronald K. Scheule, Hongmei Zhao
  • Publication number: 20150190373
    Abstract: The invention provides methods of treating a diabetic subject comprising administering a glucosylceramide synthase inhibitor to the subject.
    Type: Application
    Filed: August 20, 2014
    Publication date: July 9, 2015
    Inventors: Seng H. Cheng, Nelson S. Yew, Ronald K. Scheule, Hongmei Zhao
  • Publication number: 20150076031
    Abstract: A process for producing mesophase pitch from high-temperature coal tar comprises: removing salts and quinoline insoluble fraction from a high-temperature coal tar to obtain a decant oil; using the decant oil as a hydrogenation feedstock, or pre-distilling the decant oil to obtain a residue with a boiling point higher than 230 and formulating the residue into a hydrogenation feedstock; catalytic hydrorefining the hydrogenation feedstock to obtain a hydrofined oil; distilling the hydrofined oil to obtain hydrogenated pitch; and subjecting the hydrogenated pitch to the thermal polymerization to obtain the mesophase pitch. The process has features such as an easily controllable degree of hydrogenation, complete removal of impurities, good raw material flowability, not tending to form the carbon deposition and the coking during the process, and not tending to jam the reactor. The product has a high content of mesophase pitch, a low softening point and a low impurity content.
    Type: Application
    Filed: April 6, 2012
    Publication date: March 19, 2015
    Applicant: DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Hongmei Zhao, Jieshan Qiu, Kam Shing Philip Siu, Baoming Li, Junde Steve Lu, Nan Xiao
  • Publication number: 20150051261
    Abstract: The disclosure provides methods for treating fatty liver disease and associated conditions by inhibiting the synthesis of glucosphingolipids, as exemplified by the use of glucosylceramide synthase substrate analogs.
    Type: Application
    Filed: April 8, 2014
    Publication date: February 19, 2015
    Applicant: Genzyme Corporation
    Inventors: Hongmei Zhao, Nelson S. Yew, Seng H. Cheng, Canwen Jiang, Cynthia Marie Arbeeny
  • Patent number: 8716327
    Abstract: The disclosure provides methods for treating fatty liver disease and associated conditions by inhibiting the synthesis of glucosphingolipids, as exemplified by the use of glucosylceramide synthase substrate analogs.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: May 6, 2014
    Assignee: Genzyme Corporation
    Inventors: Hongmei Zhao, Nelson S. Yew, Seng H. Cheng, Canwen Jiang, Cynthia Marie Arbeeny
  • Publication number: 20130092602
    Abstract: A continuous reaction system is provided, which specifically relates to a continuous reaction system comprising subcritical and/or supercritical liquid as solvents and a reactant as solid. The invention can effectively prevent cavitations in the reaction system effectively, and realize maximum conversion of the solid reactant material.
    Type: Application
    Filed: September 24, 2012
    Publication date: April 18, 2013
    Inventors: Zuolin Zhu, Meg M. Sun, Chungao Su, Kangfu Gu, Hongmei Zhao, Xuemei Ma, Weiguo Yu, Daochuang Liu, Zuodong Zhu, Hongping Ye
  • Publication number: 20120022126
    Abstract: The invention provides methods of treating a diabetic subject comprising administering a glucosylceramide synthase inhibitor to the subject.
    Type: Application
    Filed: July 29, 2011
    Publication date: January 26, 2012
    Applicant: Genzyme Corporation
    Inventors: Seng H. Cheng, Nelson S. Yew, Ronald K. Scheule, Hongmei Zhao
  • Patent number: 8003617
    Abstract: The invention provides methods of treating a diabetic subject comprising administering a glucosylceramide synthase inhibitor to the subject.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: August 23, 2011
    Assignee: Genzyme Corporation
    Inventors: Seng H. Cheng, Nelson S. Yew, Ronald K. Scheule, Hongmei Zhao